HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: SRSF2 (Q01130)
Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)
Gene: SRSF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	31527615, 21182205, unassigned1953
Identification Methods	affinity chromatography technology, tandem affinity purification, cosedimentation through density gradient
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 221
+	Hs
		369664 ESR1_HUMAN (1-595): 0: 599: 100.00		SF3B4_HUMAN (4-205): 1.41e-52: 176: 17.24
+	Hs
		368886 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27
+	Hs
		369534 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP4_HUMAN (5-191): 4.16e-25: 104: 13.37
+	Hs
		370422 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP3_HUMAN (15-221): 2.48e-24: 101: 16.91
+	Hs
		370176 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP5_HUMAN (16-95): 2.11e-18: 84.4: 21.25
+	Hs
		369064 ESR1_HUMAN (1-595): 0: 599: 100.00		TIA1_HUMAN (9-184): 2.34e-16: 78.5: 10.67
+	Hs
		369421 ESR1_HUMAN (1-595): 0: 599: 100.00		TIAR_HUMAN (9-167): 1.19e-15: 76.6: 9.26
+	Hs
		369739 ESR1_HUMAN (1-595): 0: 599: 100.00		PAP1L_HUMAN (104-193): 4.46e-11: 63.5: 8.89
+	Hs
		1073609 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SF3B4_HUMAN (4-205): 1.41e-52: 176: 17.24
+	Hs
		964038 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SRSF2_HUMAN (1-221): 1.22e-43: 147: 100.00
+	Hs
		1031409 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PABP4_HUMAN (5-191): 4.16e-25: 104: 13.37
+	Hs
		1269600 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PABP3_HUMAN (15-221): 2.48e-24: 101: 16.91
+	Hs
		1269332 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PABP5_HUMAN (16-95): 2.11e-18: 84.4: 21.25
+	Hs
		680471 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TIA1_HUMAN (9-184): 2.34e-16: 78.5: 10.67
+	Hs
		963552 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TIAR_HUMAN (9-167): 1.19e-15: 76.6: 9.26
+	Hs
		377286 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		ELAV2_HUMAN (1-195): 6.01e-38: 136: 15.79
+	Hs
		516359 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27
+	Hs
		1119140 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PAP1L_HUMAN (104-193): 4.46e-11: 63.5: 8.89
+	Hs
		782537 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		PABP4_HUMAN (5-191): 4.16e-25: 104: 13.37
+	Hs
		611434 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		PABP4_HUMAN (5-191): 4.16e-25: 104: 13.37