Protein: A1AT
Alpha-1-antitrypsin (Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) (Serpin A1) [Cleaved into: Short peptide from AAT (SPAAT)]

Gene: A1AT, SERPINA1
Organism: Homo sapiens
Interactions: 161
UniProt ID: P01009

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

369284

A1AT
Alpha-1-antitrypsin

3

9

Small-scale

0.866

High

369300

ELNE
Neutrophil elastase

3

20

Small-scale

0.834

High

132959

MATN2
Matrilin-2

1

2

High-throughput

0.691

High

210637

KLK10
Kallikrein-10

1

20

High-throughput

0.691

High

369323

CTRL
Chymotrypsin-like protease CTRL-1

1

12

High-throughput

0.691

High

369368

FNDC5
Fibronectin type III domain-containing protein 5

1

5

High-throughput

0.691

High

369417

KLK4
Kallikrein-4

1

20

High-throughput

0.691

High

369344

OS9
Protein OS-9

4

5

Small-scale

0.676

High

369391

DERL1
Derlin-1

4

2

Small-scale

0.676

High

369367

GDPD1
Lysophospholipase D GDPD1

3

1

High-throughput

0.667

High

369352

FNDC1
Fibronectin type III domain-containing protein 1

1

0

High-throughput

0.656

High

369296

KLK1
Kallikrein-1

1

20

Small-scale

0.647

High

369312

PRTN3
Myeloblastin

1

20

Small-scale

0.647

High

369329

GRAM
Granzyme M

1

20

Small-scale

0.646

High

369380

ERLEC
Endoplasmic reticulum lectin 1

3

5

Small-scale

0.640

High

369397

DERL2
Derlin-2

3

2

Small-scale

0.640

High

369294

ALDH2
Aldehyde dehydrogenase, mitochondrial

3

0

High-throughput

0.638

High

369305

HSP7C
Heat shock cognate 71 kDa protein

2

5

High-throughput

0.628

High

369382

SNX27
Sorting nexin-27

2

1

High-throughput

0.628

High

369401

DDX31
ATP-dependent DNA helicase DDX31

2

3

High-throughput

0.628

High

366133

HPT
Haptoglobin

1

20

High-throughput

0.618

High

369285

AACT
Alpha-1-antichymotrypsin

1

8

High-throughput

0.618

High

369288

FINC
Fibronectin

1

5

Small-scale

0.618

High

369297

KLK3
Prostate-specific antigen

1

19

Small-scale

0.618

High

369313

ZA2G
Zinc-alpha-2-glycoprotein

1

1

High-throughput

0.618

High

369412

DD19B
ATP-dependent RNA helicase DDX19B

2

7

High-throughput

0.611

High

369321

CAH8
Carbonic anhydrase-related protein

3

2

High-throughput

0.609

High

369383

ZN558
Zinc finger protein 558

3

3

High-throughput

0.609

High

369314

1433T
14-3-3 protein theta

2

1

High-throughput

0.601

High

369332

TERA
Transitional endoplasmic reticulum ATPase

2

2

Small-scale

0.584

High

369359

SYVN1
E3 ubiquitin-protein ligase synoviolin

2

9

Small-scale

0.584

High

369376

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

2

1

Small-scale

0.584

High

188770

TMPS2
Transmembrane protease serine 2

1

20

Small-scale

0.575

High

369299

CEL2A
Chymotrypsin-like elastase family member 2A

1

14

High-throughput

0.575

High

369301

CATG
Cathepsin G

1

20

High-throughput

0.575

High

369316

KAIN
Kallistatin

1

9

High-throughput

0.575

High

369349

MK06
Mitogen-activated protein kinase 6

2

3

High-throughput

0.574

High

369371

AATC2
Putative aspartate aminotransferase, cytoplasmic 2

2

7

High-throughput

0.574

High

369404

PLK2
Serine/threonine-protein kinase PLK2

2

3

High-throughput

0.558

High

67411

GOG8A
Golgin subfamily A member 8A

1

5

High-throughput

0.536

High

219789

CHSTA
Carbohydrate sulfotransferase 10

1

4

High-throughput

0.536

High

231357

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

1

1

High-throughput

0.536

High

252498

SEP15
Selenoprotein F

1

4

High-throughput

0.536

High

351625

SG1D1
Secretoglobin family 1D member 1

1

5

High-throughput

0.536

High

369333

STX17
Syntaxin-17

1

9

High-throughput

0.536

High

369356

SFXN4
Sideroflexin-4

1

1

High-throughput

0.536

High

369373

RHBL4
Rhomboid-related protein 4

1

5

High-throughput

0.536

High

369375

ITLN2
Intelectin-2

1

2

High-throughput

0.536

High

369378

SARAF
Store-operated calcium entry-associated regulatory factor

1

9

High-throughput

0.536

High

369388

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

8

High-throughput

0.536

High

369389

EGFL8
Epidermal growth factor-like protein 8

1

3

High-throughput

0.536

High

369362

SLX4
Structure-specific endonuclease subunit SLX4

2

4

High-throughput

0.521

High

369315

CALX
Calnexin

1

4

Small-scale

0.515

High

369358

K1C27
Keratin, type I cytoskeletal 27

1

0

High-throughput

0.513

High

369400

REN3A
Regulator of nonsense transcripts 3A

1

0

High-throughput

0.513

High

369326

SSRA
Translocon-associated protein subunit alpha

1

0

Small-scale

0.512

High

369413

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

0

Small-scale

0.512

High

273740

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

1

1

Small-scale

0.506

High

369298

HS90A
Heat shock protein HSP 90-alpha

1

4

Small-scale

0.501

High

369328

LMAN1
Protein ERGIC-53

1

0

Small-scale

0.493

High

194433

P2RX6
P2X purinoceptor 6

1

1

High-throughput

0.489

High

254710

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

4

High-throughput

0.489

High

335212

CXB5
Gap junction beta-5 protein

1

1

High-throughput

0.489

High

355388

NSD2
Histone-lysine N-methyltransferase NSD2

1

1

High-throughput

0.489

High

369306

CFTR
Cystic fibrosis transmembrane conductance regulator

1

8

High-throughput

0.489

High

369319

CCR1
C-C chemokine receptor type 1

1

7

High-throughput

0.489

High

369334

DSCR6
Protein ripply3

1

6

High-throughput

0.489

High

369339

SSBP2
Single-stranded DNA-binding protein 2

1

6

High-throughput

0.489

High

369340

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

8

High-throughput

0.489

High

369351

CR021
UPF0711 protein C18orf21

1

6

High-throughput

0.489

High

369353

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

6

High-throughput

0.489

High

369360

CIR1
Corepressor interacting with RBPJ 1

1

1

High-throughput

0.489

High

369361

MICU3
Calcium uptake protein 3, mitochondrial

1

5

High-throughput

0.489

High

369363

ELOA2
Elongin-A2

1

2

High-throughput

0.489

High

369364

OR2LD
Olfactory receptor 2L13

1

4

High-throughput

0.489

High

369384

TSSK2
Testis-specific serine/threonine-protein kinase 2

1

2

High-throughput

0.489

High

369393

FUND2
FUN14 domain-containing protein 2

1

2

High-throughput

0.489

High

369402

COE2
Transcription factor COE2

1

4

High-throughput

0.489

High

369403

MBNL1
Muscleblind-like protein 1

1

5

High-throughput

0.489

High

369407

PHF11
PHD finger protein 11

1

8

High-throughput

0.489

High

369409

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

3

High-throughput

0.489

High

369414

SSUH2
Protein SSUH2 homolog

1

7

High-throughput

0.489

High

369385

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

1

High-throughput

0.481

High

179108

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

6

Small-scale

0.479

High

240437

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

361509

CERU
Ceruloplasmin

1

1

High-throughput

0.479

High

369286

APOA1
Apolipoprotein A-I

1

1

High-throughput

0.479

High

369287

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

2

High-throughput

0.479

High

369289

A1AG1
Alpha-1-acid glycoprotein 1

1

2

High-throughput

0.479

High

369290

VTDB
Vitamin D-binding protein

1

2

High-throughput

0.479

High

369291

TRFE
Serotransferrin

1

2

High-throughput

0.479

High

369292

HEMO
Hemopexin

1

2

High-throughput

0.479

High

369293

STAT
Statherin

1

1

High-throughput

0.479

High

369295

S10A9
Protein S100-A9

1

6

High-throughput

0.479

High

369303

CLUS
Clusterin

1

2

High-throughput

0.479

High

369304

BIP
Endoplasmic reticulum chaperone BiP

1

10

Small-scale

0.479

High

369308

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

369309

LEG3
Galectin-3

1

4

Small-scale

0.479

High

369318

LCN1
Lipocalin-1

1

1

High-throughput

0.479

High

369324

HNF4A
Hepatocyte nuclear factor 4-alpha

1

6

Small-scale

0.479

High

369338

HBB
Hemoglobin subunit beta

1

1

High-throughput

0.479

High

369346

SQSTM
Sequestosome-1

1

1

Small-scale

0.479

High

369348

PROL4
Proline-rich protein 4

1

1

High-throughput

0.479

High

369369

TXND5
Thioredoxin domain-containing protein 5

1

3

Small-scale

0.479

High

369377

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

369395

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

1

Small-scale

0.479

High

369406

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

369410

FBX2
F-box only protein 2

1

6

Small-scale

0.479

High

369366

MAGB6
Melanoma-associated antigen B6

1

1

High-throughput

0.470

High

369302

RAP2A
Ras-related protein Rap-2a

1

3

High-throughput

0.464

High

369320

SDC2
Syndecan-2

1

0

High-throughput

0.460

High

369390

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

Small-scale

0.460

High

369335

SRP54
Signal recognition particle subunit SRP54

1

0

Small-scale

0.458

High

229253

ANGL7
Angiopoietin-related protein 7

1

2

High-throughput

0.445

High

261040

NSMA
Sphingomyelin phosphodiesterase 2

1

7

High-throughput

0.445

High

369341

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

Small-scale

0.445

High

369347

RFTN1
Raftlin

1

1

High-throughput

0.445

High

369365

S35F6
Solute carrier family 35 member F6

1

1

High-throughput

0.445

High

369415

PRG3
Proteoglycan 3

1

1

High-throughput

0.445

High

369317

ECHM
Enoyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.439

High

369345

SMAD4
Mothers against decapentaplegic homolog 4

1

3

High-throughput

0.439

High

105060

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

277221

PITX3
Pituitary homeobox 3

1

4

Small-scale

0.437

High

318559

RHBT1
Rho-related BTB domain-containing protein 1

1

8

High-throughput

0.437

High

360694

COX3
Cytochrome c oxidase subunit 3

1

2

Small-scale

0.437

High

369327

SOX2
Transcription factor SOX-2

1

9

High-throughput

0.437

High

369342

FOXO1
Forkhead box protein O1

1

4

High-throughput

0.437

High

369343

RFA4
Replication protein A 30 kDa subunit

1

4

High-throughput

0.437

High

369374

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.437

High

369386

DERL3
Derlin-3

1

2

Small-scale

0.437

High

369394

FACD2
Fanconi anemia group D2 protein

1

10

High-throughput

0.437

High

369398

DDX24
ATP-dependent RNA helicase DDX24

1

2

High-throughput

0.437

High

369330

GPM6A
Neuronal membrane glycoprotein M6-a

1

0

High-throughput

0.426

High

369337

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

High-throughput

0.426

High

219583

B2L11
Bcl-2-like protein 11

1

2

High-throughput

0.407

High

369350

INF2
Inverted formin-2

1

3

High-throughput

0.407

High

369355

A16L1
Autophagy-related protein 16-1

1

10

High-throughput

0.407

High

369357

DEFI8
Differentially expressed in FDCP 8 homolog

1

5

High-throughput

0.407

High

369392

RSRP1
Arginine/serine-rich protein 1

1

3

High-throughput

0.407

High

369405

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

2

High-throughput

0.407

High

369408

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

9

High-throughput

0.407

High

369354

ICE2
Little elongation complex subunit 2

3

0

High-throughput

0.347

High

369310

CCNA2
Cyclin-A2

1

0

High-throughput

0.279

Low

369331

PRKX
cAMP-dependent protein kinase catalytic subunit PRKX

1

0

High-throughput

0.279

Low

369336

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

1

0

High-throughput

0.279

Low

369381

SMIM8
Small integral membrane protein 8

1

0

High-throughput

0.279

Low

369411

HDAC9
Histone deacetylase 9

1

0

High-throughput

0.279

Low

369399

MIS12
Protein MIS12 homolog

1

0

High-throughput

0.269

Low

219106

LTOR5
Ragulator complex protein LAMTOR5

1

0

Small-scale

0.251

Low

369322

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

0

High-throughput

0.251

Low

369325

GLP1R
Glucagon-like peptide 1 receptor

1

0

Small-scale

0.251

Low

369372

GSDMB
Gasdermin-B

1

0

High-throughput

0.251

Low

369396

S13A1
Solute carrier family 13 member 1

1

0

Small-scale

0.251

Low

369311

HNF1A
Hepatocyte nuclear factor 1-alpha

1

0

Small-scale

0.249

Low

369370

FBX22
F-box only protein 22

1

0

High-throughput

0.249

Low

369379

ARMC5
Armadillo repeat-containing protein 5

1

0

High-throughput

0.249

Low

369387

EYA1
Protein phosphatase EYA1

1

0

High-throughput

0.249

Low

369416

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

Small-scale

0.249

Low

369307

TFE2
Transcription factor E2-alpha

1

0

Small-scale

0.238

Low

166239

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025