HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: TOP2B (Q02880)
DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme)
Gene: TOP2B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	16794079, 21182205
Identification Methods	affinity chromatography technology, cosedimentation through density gradient
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 1626
+	Hs
		368882 ESR1_HUMAN (1-595): 0: 599: 100.00		TOP2A_HUMAN (33-1617): 0: 1625: 66.50
+	Hs
		487950 RARA_HUMAN (81-545): 1.35e-102: 320: 22.37		TOP2B_HUMAN (1-1626): 0: 1792: 100.00
+	Hs
		740506 PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35		TOP2B_HUMAN (1-1626): 0: 1792: 100.00
+	Mm
		521439 NR4A1_MOUSE (83-544): 2.7e-111: 347: 27.16		TOP2A_MOUSE (33-1613): 0: 1623: 65.32
+	Hs
		508823 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		TOP2A_HUMAN (33-1617): 0: 1625: 66.50
+	Hs
		487348 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		TOP2B_HUMAN (1-1626): 0: 1792: 100.00
+	Hs
		764667 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		CUX1_HUMAN (894-1593): 4.4e-40: 165: 11.84
+	Hs
		764601 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		CUX1_HUMAN (894-1593): 4.4e-40: 165: 11.84
+	Hs
		377155 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		CUX1_HUMAN (894-1593): 4.4e-40: 165: 11.84
+	Hs
		517813 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		NFH_HUMAN (1166-1624): 7.25e-19: 95.7: 11.98
+	Hs
		487193 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		CUX1_HUMAN (894-1593): 4.4e-40: 165: 11.84