Protein: SPB4
Serpin B4 (Leupin) (Peptidase inhibitor 11) (PI-11) (Squamous cell carcinoma antigen 2) (SCCA-2)

Gene: SPB4, SERPINB4
Organism: Homo sapiens
Interactions: 191
UniProt ID: P48594

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005615 - extracellular space
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

713343

SPB3
Serpin B3

4

8

High-throughput

0.895

High

627509

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

3

1

High-throughput

0.861

High

874823

FNDC5
Fibronectin type III domain-containing protein 5

1

6

High-throughput

0.691

High

874864

LRRN3
Leucine-rich repeat neuronal protein 3

1

1

High-throughput

0.691

High

874784

GPR18
N-arachidonyl glycine receptor

3

11

High-throughput

0.667

High

874785

KI3S1
Killer cell immunoglobulin-like receptor 3DS1

3

6

High-throughput

0.667

High

874844

SUSD3
Sushi domain-containing protein 3

3

1

High-throughput

0.667

High

874870

UD110
UDP-glucuronosyltransferase 1A10

3

3

High-throughput

0.667

High

874818

EFNMT
eEF1A lysine and N-terminal methyltransferase

3

1

High-throughput

0.662

High

469779

CATG
Cathepsin G

1

20

Small-scale

0.647

High

703244

HXD10
Homeobox protein Hox-D10

3

0

High-throughput

0.629

High

376981

ANF
Natriuretic peptides A

2

1

High-throughput

0.628

High

391586

FRIH
Ferritin heavy chain

2

4

High-throughput

0.628

High

762078

MPI
Mannose-6-phosphate isomerase

2

1

High-throughput

0.628

High

874819

CCYL1
Cyclin-Y-like protein 1

2

2

High-throughput

0.628

High

874842

RM38
Large ribosomal subunit protein mL38

2

2

High-throughput

0.628

High

874847

CDK15
Cyclin-dependent kinase 15

2

7

High-throughput

0.628

High

874859

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

2

6

High-throughput

0.628

High

874891

STA13
StAR-related lipid transfer protein 13

2

1

High-throughput

0.621

High

874782

ITA9
Integrin alpha-9

2

2

High-throughput

0.611

High

874799

MYOME
Myomegalin

2

5

High-throughput

0.611

High

600540

ZSC20
Zinc finger and SCAN domain-containing protein 20

3

2

High-throughput

0.609

High

874767

UCP2
Dicarboxylate carrier SLC25A8

3

9

High-throughput

0.609

High

874855

PHAF1
Phagosome assembly factor 1

3

2

High-throughput

0.609

High

874838

RNF25
E3 ubiquitin-protein ligase RNF25

2

0

High-throughput

0.602

High

874783

IL18
Interleukin-18

2

0

High-throughput

0.585

High

853621

MK08
Mitogen-activated protein kinase 8

1

3

Small-scale

0.578

High

874789

ZIC1
Zinc finger protein ZIC 1

2

7

High-throughput

0.574

High

874813

Z354C
Zinc finger protein 354C

2

1

High-throughput

0.574

High

874822

ASCC1
Activating signal cointegrator 1 complex subunit 1

2

1

High-throughput

0.574

High

874867

ACAD9
Complex I assembly factor ACAD9, mitochondrial

2

3

High-throughput

0.574

High

874872

SHCAF
SIN3-HDAC complex-associated factor

2

2

High-throughput

0.574

High

874876

TB22B
TBC1 domain family member 22B

2

7

High-throughput

0.574

High

874882

DPOLL
DNA polymerase lambda

2

1

High-throughput

0.558

High

874885

DD19B
ATP-dependent RNA helicase DDX19B

2

9

High-throughput

0.558

High

132579

UPK1A
Uroplakin-1a

1

6

High-throughput

0.536

High

222359

TSN6
Tetraspanin-6

1

3

High-throughput

0.536

High

254880

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

5

High-throughput

0.536

High

292582

RENR
Renin receptor

1

5

High-throughput

0.536

High

296877

RASF9
Ras association domain-containing protein 9

1

3

High-throughput

0.536

High

343237

ERR2
Steroid hormone receptor ERR2

1

8

High-throughput

0.536

High

348418

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.536

High

351670

SG1D1
Secretoglobin family 1D member 1

1

5

High-throughput

0.536

High

352696

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

4

High-throughput

0.536

High

362959

EGFR
Epidermal growth factor receptor

1

5

High-throughput

0.536

High

395676

ESR1
Estrogen receptor

1

8

High-throughput

0.536

High

463022

YES
Tyrosine-protein kinase Yes

1

1

High-throughput

0.536

High

477331

NMB
Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B]

1

1

High-throughput

0.536

High

540245

SPTB1
Spectrin beta chain, erythrocytic

1

1

High-throughput

0.536

High

602762

AATC
Aspartate aminotransferase, cytoplasmic

1

8

High-throughput

0.536

High

692013

MARK3
MAP/microtubule affinity-regulating kinase 3

1

1

High-throughput

0.536

High

717400

PDIA3
Protein disulfide-isomerase A3

1

2

High-throughput

0.536

High

719057

MIP
Lens fiber major intrinsic protein

1

1

High-throughput

0.536

High

733304

CCR1
C-C chemokine receptor type 1

1

7

High-throughput

0.536

High

733730

GRK4
G protein-coupled receptor kinase 4

1

3

High-throughput

0.536

High

834153

CSK
Tyrosine-protein kinase CSK

1

2

High-throughput

0.536

High

873848

PCP4
Calmodulin regulator protein PCP4

1

3

High-throughput

0.536

High

874761

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.536

High

874764

BMX
Cytoplasmic tyrosine-protein kinase BMX

1

3

High-throughput

0.536

High

874765

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

4

High-throughput

0.536

High

874768

STX17
Syntaxin-17

1

9

High-throughput

0.536

High

874770

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.536

High

874774

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

9

High-throughput

0.536

High

874775

GCYA1
Guanylate cyclase soluble subunit alpha-1

1

3

High-throughput

0.536

High

874778

FMOD
Fibromodulin

1

2

High-throughput

0.536

High

874781

CUL2
Cullin-2

1

6

High-throughput

0.536

High

874787

STK11
Serine/threonine-protein kinase STK11

1

4

High-throughput

0.536

High

874790

PKN2
Serine/threonine-protein kinase N2

1

7

High-throughput

0.536

High

874791

MK06
Mitogen-activated protein kinase 6

1

2

High-throughput

0.536

High

874826

O13C3
Olfactory receptor 13C3

1

4

High-throughput

0.536

High

874830

ITLN2
Intelectin-2

1

2

High-throughput

0.536

High

874833

TANK
TRAF family member-associated NF-kappa-B activator

1

1

High-throughput

0.536

High

874834

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.536

High

874835

CUL5
Cullin-5

1

6

High-throughput

0.536

High

874837

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

4

High-throughput

0.536

High

874846

FMNL2
Formin-like protein 2

1

3

High-throughput

0.536

High

874849

FCRL5
Fc receptor-like protein 5

1

1

High-throughput

0.536

High

874850

PFD5
Prefoldin subunit 5

1

1

High-throughput

0.536

High

874865

FBX44
F-box only protein 44

1

5

High-throughput

0.536

High

874874

MBNL1
Muscleblind-like protein 1

1

5

High-throughput

0.536

High

874877

KLH11
Kelch-like protein 11

1

6

High-throughput

0.536

High

874881

DKK2
Dickkopf-related protein 2

1

1

High-throughput

0.536

High

874887

FBW1A
F-box/WD repeat-containing protein 1A

1

5

High-throughput

0.536

High

874888

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

1

High-throughput

0.536

High

874890

CHMP3
Charged multivesicular body protein 3

1

1

High-throughput

0.536

High

874892

RN115
E3 ubiquitin-protein ligase RNF115

1

6

High-throughput

0.536

High

874893

NPTN
Neuroplastin

1

2

High-throughput

0.536

High

874816

SLX4
Structure-specific endonuclease subunit SLX4

2

6

High-throughput

0.521

High

874771

X3CL1
Fractalkine

1

0

High-throughput

0.513

High

874773

DAB2
Disabled homolog 2

1

0

High-throughput

0.513

High

874792

INSC
Protein inscuteable homolog

1

0

High-throughput

0.513

High

874803

DESI1
Desumoylating isopeptidase 1

1

0

High-throughput

0.513

High

874827

MYBPP
MYCBP-associated protein

1

0

High-throughput

0.513

High

874853

RNZ2
Zinc phosphodiesterase ELAC protein 2

1

0

High-throughput

0.513

High

874871

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.513

High

51531

PL8L1
PLAC8-like protein 1

1

1

High-throughput

0.489

High

135790

RTCA
RNA 3'-terminal phosphate cyclase

1

2

High-throughput

0.489

High

229222

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

4

High-throughput

0.489

High

231214

NDUS5
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

1

1

High-throughput

0.489

High

282363

MED24
Mediator of RNA polymerase II transcription subunit 24

1

1

High-throughput

0.489

High

325304

OR2A4
Olfactory receptor 2A4

1

13

High-throughput

0.489

High

327194

ZFPL1
Zinc finger protein-like 1

1

1

High-throughput

0.489

High

331644

MBD4
Methyl-CpG-binding domain protein 4

1

1

High-throughput

0.489

High

552163

ADT3
ADP/ATP translocase 3

1

7

High-throughput

0.489

High

555354

SKI
Ski oncogene

1

2

High-throughput

0.489

High

622776

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

6

High-throughput

0.489

High

666810

CCNC
Cyclin-C

1

5

High-throughput

0.489

High

853926

KI67
Proliferation marker protein Ki-67

1

1

High-throughput

0.489

High

874760

PTSS1
Phosphatidylserine synthase 1

1

2

High-throughput

0.489

High

874762

ASCL1
Achaete-scute homolog 1

1

4

High-throughput

0.489

High

874766

NDST2
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

1

1

High-throughput

0.489

High

874769

DSCR6
Protein ripply3

1

7

High-throughput

0.489

High

874772

SSBP2
Single-stranded DNA-binding protein 2

1

5

High-throughput

0.489

High

874776

EF1A2
Elongation factor 1-alpha 2

1

3

High-throughput

0.489

High

874777

GABPA
GA-binding protein alpha chain

1

5

High-throughput

0.489

High

874779

ZN154
Zinc finger protein 154

1

1

High-throughput

0.489

High

874793

ZN674
Zinc finger protein 674

1

2

High-throughput

0.489

High

874794

CR021
UPF0711 protein C18orf21

1

6

High-throughput

0.489

High

874796

LRC10
Leucine-rich repeat-containing protein 10

1

3

High-throughput

0.489

High

874797

EMC4
ER membrane protein complex subunit 4

1

3

High-throughput

0.489

High

874800

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

5

High-throughput

0.489

High

874804

DPPA4
Developmental pluripotency-associated protein 4

1

1

High-throughput

0.489

High

874805

APTX
Aprataxin

1

3

High-throughput

0.489

High

874806

ZN550
Zinc finger protein 550

1

3

High-throughput

0.489

High

874807

NEK8
Serine/threonine-protein kinase Nek8

1

4

High-throughput

0.489

High

874808

MOGT3
2-acylglycerol O-acyltransferase 3

1

6

High-throughput

0.489

High

874810

BPHL
Serine hydrolase BPHL

1

1

High-throughput

0.489

High

874811

COA5
Cytochrome c oxidase assembly factor 5

1

2

High-throughput

0.489

High

874814

CERS3
Ceramide synthase 3

1

2

High-throughput

0.489

High

874817

NRSN1
Neurensin-1

1

1

High-throughput

0.489

High

874820

PDILT
Protein disulfide-isomerase-like protein of the testis

1

5

High-throughput

0.489

High

874821

FRMD1
FERM domain-containing protein 1

1

3

High-throughput

0.489

High

874825

ANKK1
Ankyrin repeat and protein kinase domain-containing protein 1

1

5

High-throughput

0.489

High

874828

STK35
Serine/threonine-protein kinase 35

1

1

High-throughput

0.489

High

874829

RHBL4
Rhomboid-related protein 4

1

4

High-throughput

0.489

High

874836

PIGT
GPI-anchor transamidase component PIGT

1

4

High-throughput

0.489

High

874840

SARAF
Store-operated calcium entry-associated regulatory factor

1

7

High-throughput

0.489

High

874845

F227B
Protein FAM227B

1

3

High-throughput

0.489

High

874848

TEFM
Transcription elongation factor, mitochondrial

1

3

High-throughput

0.489

High

874851

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

6

High-throughput

0.489

High

874852

TREX2
Three prime repair exonuclease 2

1

2

High-throughput

0.489

High

874854

SH23A
SH2 domain-containing protein 3A

1

9

High-throughput

0.489

High

874856

MMTA2
Multiple myeloma tumor-associated protein 2

1

5

High-throughput

0.489

High

874858

FUND2
FUN14 domain-containing protein 2

1

2

High-throughput

0.489

High

874860

SRRT
Serrate RNA effector molecule homolog

1

5

High-throughput

0.489

High

874866

ZDHC6
Palmitoyltransferase ZDHHC6

1

1

High-throughput

0.489

High

874869

COE2
Transcription factor COE2

1

5

High-throughput

0.489

High

874873

TSSP
Thymus-specific serine protease

1

4

High-throughput

0.489

High

874875

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.489

High

874878

RM39
Large ribosomal subunit protein mL39

1

1

High-throughput

0.489

High

874879

PK2L2
Polycystin-2-like protein 2

1

2

High-throughput

0.489

High

874880

THA10
THAP domain-containing protein 10

1

1

High-throughput

0.489

High

874883

SMBT1
Scm-like with four MBT domains protein 1

1

1

High-throughput

0.489

High

874884

PHF11
PHD finger protein 11

1

8

High-throughput

0.489

High

874886

CD11A
Cyclin-dependent kinase 11A

1

1

High-throughput

0.489

High

874889

SSUH2
Protein SSUH2 homolog

1

8

High-throughput

0.489

High

424160

S10A8
Protein S100-A8

1

7

High-throughput

0.479

High

444932

S10A9
Protein S100-A9

1

9

High-throughput

0.479

High

623184

RO52
E3 ubiquitin-protein ligase TRIM21

1

6

High-throughput

0.479

High

724544

S10A7
Protein S100-A7

1

9

High-throughput

0.479

High

868659

LEG7
Galectin-7

1

5

High-throughput

0.479

High

874786

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

874809

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

Small-scale

0.479

High

874832

ESR2
Estrogen receptor beta

1

8

High-throughput

0.479

High

874861

FACD2
Fanconi anemia group D2 protein

1

11

High-throughput

0.479

High

874788

USF2
Upstream stimulatory factor 2

1

7

High-throughput

0.470

High

649782

SPR2D
Small proline-rich protein 2D

1

0

High-throughput

0.458

High

874843

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

Small-scale

0.458

High

874763

GPC3
Glypican-3

1

3

High-throughput

0.445

High

874801

RNLS
Renalase

1

1

Small-scale

0.445

High

874802

A16L1
Autophagy-related protein 16-1

1

10

High-throughput

0.445

High

874815

SULF2
Extracellular sulfatase Sulf-2

1

1

High-throughput

0.445

High

874863

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

5

High-throughput

0.445

High

371445

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.437

High

606408

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.437

High

874862

DDX24
ATP-dependent RNA helicase DDX24

1

4

High-throughput

0.437

High

874894

SCC4
MAU2 chromatid cohesion factor homolog

1

1

High-throughput

0.437

High

96894

E9PDS3
Integrin subunit alpha 9

1

2

High-throughput

0.407

High

874798

Q5JQP4
DNA polymerase

1

1

High-throughput

0.407

High

874795

CCD92
Coiled-coil domain-containing protein 92

3

0

High-throughput

0.347

High

874857

YJU2
Splicing factor YJU2

3

0

High-throughput

0.347

High

635160

CP3A5
Cytochrome P450 3A5

2

0

High-throughput

0.328

High

874812

ZFAN4
AN1-type zinc finger protein 4

2

0

High-throughput

0.328

High

874831

PPM1E
Protein phosphatase 1E

2

0

High-throughput

0.328

High

874839

UPP
Uracil phosphoribosyltransferase homolog

2

0

High-throughput

0.328

High

504832

H2AB1
Histone H2A-Bbd type 1

1

0

High-throughput

0.279

Low

629492

PO3F3
POU domain, class 3, transcription factor 3

1

0

High-throughput

0.279

Low

874780

MMRN1
Multimerin-1

1

0

High-throughput

0.279

Low

874824

UBAC2
Ubiquitin-associated domain-containing protein 2

1

0

High-throughput

0.279

Low

874841

FWCH2
FLYWCH family member 2

1

0

High-throughput

0.279

Low

874868

L2HDH
L-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025