HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: AKP13 (Q12802)
A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47)
Gene: AKAP13

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.573

Property	Details
Experiments	9627117
Identification Methods	pull down, two hybrid, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 2813
+	Hs
		1016929 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		AKP13_HUMAN (1-2813): 0: 990: 100.00
+	Hs
		167059 ESR1_HUMAN (1-595): 0: 599: 100.00		ARHGB_HUMAN (1836-2505): 4.28e-98: 353: 19.67
+	Hs
		370588 ESR1_HUMAN (1-595): 0: 599: 100.00		ARHGC_HUMAN (1849-2490): 2.91e-97: 351: 20.93
+	Hs
		370586 ESR1_HUMAN (1-595): 0: 599: 100.00		ITSN2_HUMAN (1981-2361): 1.35e-80: 299: 19.80
+	Hs
		369908 ESR1_HUMAN (1-595): 0: 599: 100.00		ARHG8_HUMAN (1893-2419): 3.08e-85: 295: 17.84
+	Hs
		370063 ESR1_HUMAN (1-595): 0: 599: 100.00		PREX1_HUMAN (1947-2653): 1.57e-73: 276: 13.52
+	Hs
		370149 ESR1_HUMAN (1-595): 0: 599: 100.00		ARHG2_HUMAN (1753-2761): 2e-73: 269: 34.62
+	Hs
		200765 ESR1_HUMAN (1-595): 0: 599: 100.00		ARHG9_HUMAN (1946-2364): 8.41e-71: 250: 15.31
+	Hs
		370679 ESR1_HUMAN (1-595): 0: 599: 100.00		VAV3_HUMAN (1810-2622): 3.76e-62: 233: 12.95
+	Hs
		167102 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		ARHGB_HUMAN (1836-2505): 4.28e-98: 353: 19.67
+	Hs
		1269786 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		ARHGC_HUMAN (1849-2490): 2.91e-97: 351: 20.93
+	Hs
		370229 ESR1_HUMAN (1-595): 0: 599: 100.00		FGD4_HUMAN (1895-2361): 1.2e-35: 150: 19.25
+	Hs
		369096 ESR1_HUMAN (1-595): 0: 599: 100.00		MYH9_HUMAN (1492-2562): 6.9e-29: 129: 8.90
+	Hs
		1269784 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		ITSN2_HUMAN (1981-2361): 1.35e-80: 299: 19.80
+	Hs
		1254025 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PREX1_HUMAN (1947-2653): 1.57e-73: 276: 13.52
+	Hs
		1269288 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		ARHG2_HUMAN (1753-2761): 2e-73: 269: 34.62
+	Hs
		724944 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MYH9_HUMAN (1492-2562): 6.9e-29: 129: 8.90
+	Hs
		522631 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MYH7_HUMAN (2256-2811): 3.64e-23: 110: 9.98
+	Hs
		587127 RXRA_HUMAN (65-551): 4.55e-127: 383: 26.47		MYH9_HUMAN (1492-2562): 6.9e-29: 129: 8.90
+	Hs
		1269900 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MYH13_HUMAN (1412-2506): 3.36e-19: 97.9: 8.39