HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: PABP4 (Q13310)
Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP)
Gene: PABPC4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	31527615, 33731348, unassigned1953
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 644
+	Hs
		368886 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP1_HUMAN (1-644): 0: 542: 74.54
+	Hs
		370422 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP3_HUMAN (1-644): 7.04e-175: 513: 68.98
+	Hs
		369739 ESR1_HUMAN (1-595): 0: 599: 100.00		PAP1L_HUMAN (1-636): 6.79e-165: 487: 63.89
+	Hs
		1031409 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PABP4_HUMAN (1-644): 0: 585: 100.00
+	Hs
		782537 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		PABP4_HUMAN (1-644): 0: 585: 100.00
+	Hs
		1269600 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PABP3_HUMAN (1-644): 7.04e-175: 513: 68.98
+	Hs
		611434 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		PABP4_HUMAN (1-644): 0: 585: 100.00
+	Hs
		1119140 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PAP1L_HUMAN (1-636): 6.79e-165: 487: 63.89
+	Hs
		516359 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		PABP1_HUMAN (1-644): 0: 542: 74.54
+	Mm
		509289 RARA_MOUSE (81-545): 8.36e-104: 323: 22.37		PABP1_MOUSE (1-644): 0: 542: 74.69
+	Hs
		368961 ESR1_HUMAN (1-595): 0: 599: 100.00		NUCL_HUMAN (2-89): 1.4e-20: 98.4: 31.82
+	Hs
		487081 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		PABP1_HUMAN (1-644): 0: 542: 74.54
+	Hs
		370176 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP5_HUMAN (4-93): 1.22e-15: 81: 23.33
+	Hs
		369064 ESR1_HUMAN (1-595): 0: 599: 100.00		TIA1_HUMAN (4-109): 7.62e-12: 69.5: 24.53
+	Hs
		582413 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		NUCL_HUMAN (2-89): 1.4e-20: 98.4: 31.82
+	Hs
		1269332 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PABP5_HUMAN (4-93): 1.22e-15: 81: 23.33
+	Hs
		680471 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TIA1_HUMAN (4-109): 7.62e-12: 69.5: 24.53
+	Hs
		377077 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		NUCL_HUMAN (2-89): 1.4e-20: 98.4: 31.82