HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: NHRF2 (Q15599)
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Gene: NHERF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31527615, unassigned1953
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0008013 - beta-catenin binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 337
+	Hs
		67904 ESR1_HUMAN (1-595): 0: 599: 100.00		PDZ1P_HUMAN (4-131): 1.03e-19: 91.2: 33.59
+	Hs
		280012 ESR1_HUMAN (1-595): 0: 599: 100.00		MPDZ_HUMAN (7-184): 3.68e-14: 75.7: 21.16
+	Hs
		369502 ESR1_HUMAN (1-595): 0: 599: 100.00		DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31
+	Hs
		370053 ESR1_HUMAN (1-595): 0: 599: 100.00		INADL_HUMAN (3-129): 2.49e-13: 73: 21.81
+	Hs
		369500 ESR1_HUMAN (1-595): 0: 599: 100.00		PTN13_HUMAN (89-239): 2.59e-11: 66.9: 21.05
+	Hs
		369773 ESR1_HUMAN (1-595): 0: 599: 100.00		NHRF3_HUMAN (148-263): 7.43e-11: 65: 28.45
+	Hs
		370138 ESR1_HUMAN (1-595): 0: 599: 100.00		DLG3_HUMAN (89-220): 8.62e-10: 61.9: 17.99
+	Hs
		370532 ESR1_HUMAN (1-595): 0: 599: 100.00		LIN7C_HUMAN (9-87): 8.5e-09: 56.6: 40.74
+	Hs
		1021541 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31
+	Hs
		1246417 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		INADL_HUMAN (3-129): 2.49e-13: 73: 21.81
+	Hs
		1050020 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		1020200 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PTN13_HUMAN (89-239): 2.59e-11: 66.9: 21.05
+	Hs
		1269383 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71
+	Hs
		1269730 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		LIN7C_HUMAN (9-87): 8.5e-09: 56.6: 40.74
+	Hs
		1050096 NR2E1_HUMAN (171-549): 5.7e-110: 336: 29.12		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		280019 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		MPDZ_HUMAN (7-184): 3.68e-14: 75.7: 21.16
+	Hs
		377728 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		LIN7C_HUMAN (9-87): 8.5e-09: 56.6: 40.74