Protein: RAP1B
Ras-related protein Rap-1b (EC 3.6.5.2) (GTP-binding protein smg p21B)

Gene: RAP1B
Organism: Homo sapiens
Interactions: 198
UniProt ID: P61224

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0003925 - G protein activity
GO:0005525 - GTP binding
GO:0005811 - lipid droplet
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

959376

RSLAA
Ras-like protein family member 10A

3

20

High-throughput

0.861

High

911816

GDS1
Rap1 GTPase-GDP dissociation stimulator 1

3

10

High-throughput

0.855

High

959321

GNDS
Ral guanine nucleotide dissociation stimulator

3

20

Small-scale

0.843

High

182042

RGL2
Ral guanine nucleotide dissociation stimulator-like 2

2

20

Small-scale

0.800

High

578435

BRAF
Serine/threonine-protein kinase B-raf

2

20

High-throughput

0.770

High

159589

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

20

Small-scale

0.724

High

959355

ZDH17
Palmitoyltransferase ZDHHC17

1

20

High-throughput

0.698

High

959379

RAB7B
Ras-related protein Rab-7b

1

20

High-throughput

0.698

High

389210

FINC
Fibronectin

1

13

High-throughput

0.691

High

679123

DNJB1
DnaJ homolog subfamily B member 1

1

5

High-throughput

0.691

High

959358

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

13

High-throughput

0.691

High

959367

RIN3
Ras and Rab interactor 3

1

20

High-throughput

0.691

High

959416

RGL1
Ral guanine nucleotide dissociation stimulator-like 1

1

20

High-throughput

0.691

High

959368

PLPR1
Phospholipid phosphatase-related protein type 1

3

2

High-throughput

0.667

High

866516

RPGP1
Rap1 GTPase-activating protein 1

1

14

Small-scale

0.665

High

959373

RASF5
Ras association domain-containing protein 5

1

10

High-throughput

0.662

High

959336

CLM2
CMRF35-like molecule 2

1

0

High-throughput

0.656

High

720602

GRPR
Gastrin-releasing peptide receptor

2

7

High-throughput

0.628

High

959403

PACC1
Proton-activated chloride channel

2

1

High-throughput

0.628

High

959354

MYLK4
Myosin light chain kinase family member 4

1

8

High-throughput

0.618

High

959412

NRBP2
Nuclear receptor-binding protein 2

1

20

High-throughput

0.618

High

126534

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

335726

RPGF3
Rap guanine nucleotide exchange factor 3

1

20

Small-scale

0.618

High

400584

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.618

High

466185

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

580968

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

601227

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

630749

RAB4A
Ras-related protein Rab-4A

1

20

High-throughput

0.618

High

820617

CEAM6
Cell adhesion molecule CEACAM6

1

10

High-throughput

0.618

High

845577

MUC18
Cell surface glycoprotein MUC18

1

20

High-throughput

0.618

High

944969

RAB25
Ras-related protein Rab-25

1

20

High-throughput

0.618

High

953375

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

955013

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

957902

RAB14
Ras-related protein Rab-14

1

19

High-throughput

0.618

High

959310

RAP1B
Ras-related protein Rap-1b

1

19

High-throughput

0.618

High

959311

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

959313

RB11A
Ras-related protein Rab-11A

1

18

High-throughput

0.618

High

959314

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

959315

RAP1A
Ras-related protein Rap-1A

1

19

High-throughput

0.618

High

959316

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

959323

PAK2
Serine/threonine-protein kinase PAK 2

1

20

High-throughput

0.618

High

959332

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

959388

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

19

High-throughput

0.618

High

959402

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

959406

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

959409

ANLN
Anillin

1

10

High-throughput

0.618

High

959419

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.618

High

619664

VCAM1
Vascular cell adhesion protein 1

2

17

High-throughput

0.601

High

959370

NEK7
Serine/threonine-protein kinase Nek7

1

4

High-throughput

0.594

High

139121

KRIT1
Krev interaction trapped protein 1

1

20

Small-scale

0.575

High

959329

RIN1
Ras and Rab interactor 1

1

20

High-throughput

0.575

High

959340

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

14

High-throughput

0.575

High

959426

GAB2
GRB2-associated-binding protein 2

1

20

High-throughput

0.575

High

905734

CAV2
Caveolin-2

2

8

High-throughput

0.571

High

959338

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

20

High-throughput

0.553

High

959349

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.553

High

959431

PKHM1
Pleckstrin homology domain-containing family M member 1

1

10

Small-scale

0.553

High

959434

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

3

High-throughput

0.553

High

833402

RGS2
Regulator of G-protein signaling 2

1

9

High-throughput

0.541

High

292605

RENR
Renin receptor

1

6

High-throughput

0.536

High

482871

TPM1
Tropomyosin alpha-1 chain

1

6

High-throughput

0.536

High

611816

RL35A
Large ribosomal subunit protein eL33

1

2

High-throughput

0.536

High

683636

ITB8
Integrin beta-8

1

19

High-throughput

0.536

High

732969

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

7

High-throughput

0.536

High

853959

KI67
Proliferation marker protein Ki-67

1

12

High-throughput

0.536

High

959343

SYT6
Synaptotagmin-6

1

10

High-throughput

0.536

High

959344

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

3

High-throughput

0.536

High

959348

I20RB
Interleukin-20 receptor subunit beta

1

5

High-throughput

0.536

High

959351

DHB13
17-beta-hydroxysteroid dehydrogenase 13

1

14

High-throughput

0.536

High

959366

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

16

High-throughput

0.536

High

959377

STAM1
Signal transducing adapter molecule 1

1

12

High-throughput

0.536

High

959382

OPTN
Optineurin

1

20

High-throughput

0.536

High

959390

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

6

High-throughput

0.536

High

959392

TCAB1
Telomerase Cajal body protein 1

1

8

High-throughput

0.536

High

959397

DERL2
Derlin-2

1

2

High-throughput

0.536

High

959398

TOLIP
Toll-interacting protein

1

1

High-throughput

0.536

High

959411

CENPM
Centromere protein M

1

3

High-throughput

0.536

High

959420

LIMA1
LIM domain and actin-binding protein 1

1

20

High-throughput

0.536

High

959425

DICER
Endoribonuclease Dicer

1

1

High-throughput

0.536

High

959427

NTNG1
Netrin-G1

1

2

High-throughput

0.536

High

697828

CALR
Calreticulin

1

5

High-throughput

0.515

High

787958

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

6

High-throughput

0.515

High

116941

J3KNB8
Mitogen-activated protein kinase kinase kinase 4

1

12

High-throughput

0.514

High

472394

FGF4
Fibroblast growth factor 4

1

0

High-throughput

0.513

High

959317

RT35
Small ribosomal subunit protein mS35

1

0

High-throughput

0.513

High

959342

UBR4
E3 ubiquitin-protein ligase UBR4

1

0

High-throughput

0.513

High

959345

ICE2
Little elongation complex subunit 2

1

0

High-throughput

0.513

High

959365

SEN2
tRNA-splicing endonuclease subunit Sen2

1

0

High-throughput

0.513

High

959381

T4S18
Transmembrane 4 L6 family member 18

1

0

High-throughput

0.513

High

959387

TECTB
Beta-tectorin

1

0

High-throughput

0.513

High

959400

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

High-throughput

0.513

High

959401

GHITM
Growth hormone-inducible transmembrane protein

1

0

High-throughput

0.513

High

959404

CB39L
Calcium-binding protein 39-like

1

0

High-throughput

0.513

High

959421

PADI3
Protein-arginine deiminase type-3

1

0

High-throughput

0.513

High

413518

P53
Cellular tumor antigen p53

1

2

High-throughput

0.508

High

560843

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

1

2

High-throughput

0.508

High

907301

APLP1
Amyloid beta precursor like protein 1

1

13

High-throughput

0.508

High

959319

TLE1
Transducin-like enhancer protein 1

1

6

High-throughput

0.508

High

959389

TCPH
T-complex protein 1 subunit eta

1

9

High-throughput

0.508

High

959391

CAB45
45 kDa calcium-binding protein

1

13

High-throughput

0.508

High

959424

FAF1
FAS-associated factor 1

1

13

High-throughput

0.508

High

421840

A4
Amyloid-beta precursor protein

1

17

High-throughput

0.501

High

959359

RPTOR
Regulatory-associated protein of mTOR

1

6

Small-scale

0.501

High

182262

WDR46
WD repeat-containing protein 46

1

8

High-throughput

0.489

High

210738

KLK10
Kallikrein-10

1

7

High-throughput

0.489

High

702514

ACADL
Long-chain specific acyl-CoA dehydrogenase, mitochondrial

1

3

High-throughput

0.489

High

959335

RTN1
Reticulon-1

1

13

High-throughput

0.489

High

959339

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.489

High

959347

SHSA2
Protein shisa-2 homolog

1

2

High-throughput

0.489

High

959405

MAGF1
Melanoma-associated antigen F1

1

2

High-throughput

0.489

High

959407

NCK5L
Nck-associated protein 5-like

1

2

High-throughput

0.489

High

959428

AP3M1
AP-3 complex subunit mu-1

1

9

High-throughput

0.489

High

959430

DMXL1
DmX-like protein 1

1

9

High-throughput

0.489

High

350287

DDAH2
Putative hydrolase DDAH2

1

0

High-throughput

0.486

High

369651

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.486

High

573054

KPYM
Pyruvate kinase PKM

1

0

High-throughput

0.486

High

959326

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.486

High

241269

PRKN
E3 ubiquitin-protein ligase parkin

1

14

High-throughput

0.479

High

323272

TRI37
E3 ubiquitin-protein ligase TRIM37

1

14

High-throughput

0.479

High

536876

HSP7C
Heat shock cognate 71 kDa protein

1

7

High-throughput

0.479

High

558000

XRCC6
X-ray repair cross-complementing protein 6

1

3

High-throughput

0.479

High

565279

ITA4
Integrin alpha-4

1

20

High-throughput

0.479

High

659425

CRCM
Colorectal mutant cancer protein

1

5

High-throughput

0.479

High

883202

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

8

High-throughput

0.479

High

942523

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

20

High-throughput

0.479

High

947100

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

2

High-throughput

0.479

High

959312

ARF6
ADP-ribosylation factor 6

1

18

High-throughput

0.479

High

959318

VIGLN
Vigilin

1

11

High-throughput

0.479

High

959320

KLC1
Kinesin light chain 1

1

7

High-throughput

0.479

High

959327

BIRC3
Baculoviral IAP repeat-containing protein 3

1

10

High-throughput

0.479

High

959328

CUL4A
Cullin-4A

1

8

High-throughput

0.479

High

959353

PAQR2
Adiponectin receptor protein 2

1

2

Small-scale

0.479

High

959360

EMC5
ER membrane protein complex subunit 5

1

4

High-throughput

0.479

High

959364

RN149
E3 ubiquitin-protein ligase RNF149

1

14

High-throughput

0.479

High

959374

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

5

High-throughput

0.479

High

959385

CI072
Guanine nucleotide exchange factor C9orf72

1

6

High-throughput

0.479

High

959393

FACD2
Fanconi anemia group D2 protein

1

17

High-throughput

0.479

High

959394

ACE2
Angiotensin-converting enzyme 2

1

4

High-throughput

0.479

High

959395

TRI31
E3 ubiquitin-protein ligase TRIM31

1

13

High-throughput

0.479

High

959418

HDAC6
Protein deacetylase HDAC6

1

9

High-throughput

0.479

High

959422

FZR1
Fizzy-related protein homolog

1

5

High-throughput

0.479

High

421151

SCG1
Secretogranin-1

1

2

High-throughput

0.464

High

539149

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

1

High-throughput

0.464

High

913831

ZN135
Zinc finger protein 135

1

1

High-throughput

0.464

High

959341

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

2

High-throughput

0.464

High

959423

KMT2B
Histone-lysine N-methyltransferase 2B

1

9

High-throughput

0.464

High

959433

CSAD
Cysteine sulfinic acid decarboxylase

1

4

High-throughput

0.464

High

125371

LEG9
Galectin-9

1

9

High-throughput

0.445

High

142319

PEX7
Peroxisomal targeting signal 2 receptor

1

6

High-throughput

0.445

High

261147

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.445

High

369172

OAS1
2'-5'-oligoadenylate synthase 1

1

2

High-throughput

0.445

High

529486

TAU
Microtubule-associated protein tau

1

18

High-throughput

0.445

High

959322

CSN1
COP9 signalosome complex subunit 1

1

1

High-throughput

0.445

High

959330

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

6

High-throughput

0.445

High

959337

S22A6
Solute carrier family 22 member 6

1

7

High-throughput

0.445

High

959357

DND1
Dead end protein homolog 1

1

5

High-throughput

0.445

High

959363

CD177
CD177 antigen

1

6

Small-scale

0.445

High

959371

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

20

High-throughput

0.445

High

959386

MF14A
Hippocampus abundant transcript 1 protein

1

10

High-throughput

0.445

High

959396

ZDHC5
Palmitoyltransferase ZDHHC5

1

20

High-throughput

0.445

High

959413

DDX28
Probable ATP-dependent RNA helicase DDX28

1

7

High-throughput

0.445

High

959432

PCDG9
Protocadherin gamma-A9

1

3

High-throughput

0.445

High

588366

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.437

High

695098

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.437

High

767855

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.437

High

959324

TIF1B
Transcription intermediary factor 1-beta

1

5

High-throughput

0.437

High

959331

EMC2
ER membrane protein complex subunit 2

1

7

High-throughput

0.437

High

959333

EZH2
Histone-lysine N-methyltransferase EZH2

1

5

High-throughput

0.437

High

959334

E2F4
Transcription factor E2F4

1

3

High-throughput

0.437

High

959362

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

5

High-throughput

0.437

High

959375

ESR2
Estrogen receptor beta

1

18

High-throughput

0.437

High

959414

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

4

High-throughput

0.437

High

143731

WN10B
Protein Wnt-10b

1

0

High-throughput

0.426

High

959369

F174A
Membrane protein FAM174A

1

0

High-throughput

0.426

High

959429

SBDS
Ribosome maturation protein SBDS

1

0

High-throughput

0.426

High

109556

G5E9S8
Kinesin light chain

1

6

High-throughput

0.407

High

330103

VENTX
Homeobox protein VENTX

1

2

High-throughput

0.407

High

959325

RM49
Large ribosomal subunit protein mL49

1

3

High-throughput

0.407

High

959361

TTC9C
Tetratricopeptide repeat protein 9C

1

3

High-throughput

0.407

High

959372

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

1

High-throughput

0.407

High

959383

SAAL1
Protein SAAL1

1

2

High-throughput

0.407

High

959410

ZN331
Zinc finger protein 331

1

3

High-throughput

0.407

High

933994

PLTP
Phospholipid transfer protein

2

0

High-throughput

0.318

High

253829

TPST2
Protein-tyrosine sulfotransferase 2

1

0

High-throughput

0.279

Low

617671

XRCC1
DNA repair protein XRCC1

1

0

High-throughput

0.279

Low

959356

CBCO1
Ciliary-associated calcium-binding coiled-coil protein 1

1

0

High-throughput

0.279

Low

959378

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.279

Low

959384

EAF1
ELL-associated factor 1

1

0

High-throughput

0.279

Low

959399

PED1A
PC-esterase domain-containing protein 1A

1

0

High-throughput

0.279

Low

959408

NGRN
Neugrin

1

0

High-throughput

0.279

Low

959415

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

0

High-throughput

0.279

Low

959346

TPGS2
Tubulin polyglutamylase complex subunit 2

1

0

High-throughput

0.269

Low

959352

ZFHX4
Zinc finger homeobox protein 4

1

0

High-throughput

0.269

Low

959350

RD3
Protein RD3

1

0

High-throughput

0.249

Low

959380

PP14B
Protein phosphatase 1 regulatory subunit 14B

1

0

Small-scale

0.249

Low

598717

ANFB
Natriuretic peptides B

1

0

High-throughput

0.232

Low

959417

KANL3
KAT8 regulatory NSL complex subunit 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025