HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: WDR5B (Q86VZ2)
WD repeat-containing protein 5B
Gene: WDR5B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.50	0.407

Property	Details
Experiments	16603732
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 330
+	Hs
		369305 ESR1_HUMAN (1-595): 0: 599: 100.00		WDR5_HUMAN (2-286): 4.02e-95: 287: 29.21
+	Hs
		370309 ESR1_HUMAN (1-595): 0: 599: 100.00		TBL1Y_HUMAN (62-330): 1.59e-59: 200: 24.40
+	Hs
		196938 ESR1_HUMAN (1-595): 0: 599: 100.00		PRP4_HUMAN (125-330): 6.22e-50: 175: 22.43
+	Hs
		370377 ESR1_HUMAN (1-595): 0: 599: 100.00		TBL1R_HUMAN (120-330): 3.57e-48: 170: 28.00
+	Hs
		209373 ESR1_HUMAN (1-595): 0: 599: 100.00		PLRG1_HUMAN (158-328): 2.42e-40: 149: 28.66
+	Hs
		369721 ESR1_HUMAN (1-595): 0: 599: 100.00		SMU1_HUMAN (39-326): 3.4e-36: 138: 29.70
+	Hs
		903403 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		WDR5_HUMAN (2-286): 4.02e-95: 287: 29.21
+	Hs
		369669 ESR1_HUMAN (1-595): 0: 599: 100.00		TAF5_HUMAN (159-326): 3.6e-11: 66.2: 24.75
+	Hs
		782513 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		WDR5_HUMAN (2-286): 4.02e-95: 287: 29.21
+	Mm
		903664 ERR2_MOUSE (92-547): 6.98e-113: 345: 34.42		WDR5_MOUSE (2-286): 4.02e-95: 287: 29.21
+	Hs
		377562 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		FBXW7_HUMAN (1-319): 1.47e-88: 281: 28.40
+	Hs
		1269467 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TBL1Y_HUMAN (62-330): 1.59e-59: 200: 24.40
+	Hs
		197064 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PRP4_HUMAN (125-330): 6.22e-50: 175: 22.43
+	Hs
		1269548 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TBL1R_HUMAN (120-330): 3.57e-48: 170: 28.00
+	Hs
		209465 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PLRG1_HUMAN (158-328): 2.42e-40: 149: 28.66
+	Hs
		1103005 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SMU1_HUMAN (39-326): 3.4e-36: 138: 29.70
+	Hs
		1269746 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		NLE1_HUMAN (193-329): 6.37e-33: 128: 22.38
+	Hs
		245574 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		TBL1X_HUMAN (120-330): 1.23e-48: 173: 27.56
+	Hs
		1074801 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TAF5_HUMAN (159-326): 3.6e-11: 66.2: 24.75
+	Hs
		782550 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		TAF5_HUMAN (159-326): 3.6e-11: 66.2: 24.75