Protein: GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 (Gamma-9)

Gene: GBG8, GNG8
Organism: Homo sapiens
Interactions: 133
UniProt ID: Q9UK08

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0005834 - heterotrimeric G-protein complex
GO:0005886 - plasma membrane
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0007399 - nervous system development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

379053

PIGR
Polymeric immunoglobulin receptor

1

0

High-throughput

0.656

High

724435

COR1A
Coronin-1A

1

0

High-throughput

0.656

High

1437756

GBB4
Guanine nucleotide-binding protein subunit beta-4

3

20

Small-scale

0.656

High

983612

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

2

20

Small-scale

0.619

High

163657

GNB5
Guanine nucleotide-binding protein subunit beta-5

2

20

High-throughput

0.601

High

418762

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

2

20

High-throughput

0.601

High

482650

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

2

20

High-throughput

0.601

High

716061

GNA11
Guanine nucleotide-binding protein subunit alpha-11

2

20

High-throughput

0.601

High

893542

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

2

20

High-throughput

0.601

High

989890

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

2

20

High-throughput

0.601

High

1125946

GNA13
Guanine nucleotide-binding protein subunit alpha-13

2

20

High-throughput

0.601

High

984327

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

2

20

Small-scale

0.571

High

597377

GBB3
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

1

20

Small-scale

0.561

High

1130034

KCTD2
BTB/POZ domain-containing protein KCTD2

2

12

High-throughput

0.549

High

1328693

KCD17
BTB/POZ domain-containing protein KCTD17

2

10

High-throughput

0.549

High

1420702

FTO
Alpha-ketoglutarate-dependent dioxygenase FTO

2

2

High-throughput

0.549

High

126011

RB27B
Ras-related protein Rab-27B

1

1

High-throughput

0.536

High

366591

CFAB
Complement factor B

1

1

High-throughput

0.536

High

369280

ANT3
Antithrombin-III

1

3

High-throughput

0.536

High

369932

CO3
Complement C3

1

2

High-throughput

0.536

High

387339

APOA1
Apolipoprotein A-I

1

1

High-throughput

0.536

High

387757

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

3

High-throughput

0.536

High

387916

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

3

High-throughput

0.536

High

388023

FIBG
Fibrinogen gamma chain

1

3

High-throughput

0.536

High

389556

FINC
Fibronectin

1

1

High-throughput

0.536

High

390967

TRFE
Serotransferrin

1

1

High-throughput

0.536

High

391102

TRFL
Lactotransferrin

1

1

High-throughput

0.536

High

399516

C4BPA
C4b-binding protein alpha chain

1

4

High-throughput

0.536

High

403030

ANXA1
Annexin A1

1

1

High-throughput

0.536

High

405631

HRG
Histidine-rich glycoprotein

1

1

High-throughput

0.536

High

445285

S10A6
Protein S100-A6

1

1

High-throughput

0.536

High

469845

CATG
Cathepsin G

1

4

High-throughput

0.536

High

507413

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

3

High-throughput

0.536

High

539502

ITAM
Integrin alpha-M

1

1

High-throughput

0.536

High

553736

ANXA3
Annexin A3

1

1

High-throughput

0.536

High

568186

PLSL
Plastin-2

1

1

High-throughput

0.536

High

618491

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

1

20

High-throughput

0.536

High

664089

PRTN3
Myeloblastin

1

5

High-throughput

0.536

High

1128888

ITIH4
Inter-alpha-trypsin inhibitor heavy chain H4

1

2

High-throughput

0.536

High

1438754

MUC5B
Mucin-5B

1

3

High-throughput

0.536

High

733748

CXCR5
C-X-C chemokine receptor type 5

1

1

Small-scale

0.515

High

361557

CERU
Ceruloplasmin

1

0

High-throughput

0.513

High

366381

PLMN
Plasminogen

1

0

High-throughput

0.513

High

403239

APOB
Apolipoprotein B-100

1

0

High-throughput

0.513

High

416971

CY24B
NADPH oxidase 2

1

0

High-throughput

0.513

High

424106

ITB2
Integrin beta-2

1

0

High-throughput

0.513

High

442520

GELS
Gelsolin

1

0

High-throughput

0.513

High

704461

GRAN
Grancalcin

1

0

High-throughput

0.513

High

912641

GDIR2
Rho GDP-dissociation inhibitor 2

1

0

High-throughput

0.513

High

1192003

TBB8
Tubulin beta-8 chain

1

0

High-throughput

0.513

High

1249455

OLFM4
Olfactomedin-4

1

0

High-throughput

0.513

High

1333517

GOLM1
Golgi membrane protein 1

1

0

High-throughput

0.513

High

1387175

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.513

High

337653

GNAS3
Neuroendocrine secretory protein 55

2

8

High-throughput

0.504

High

63059

POTEF
POTE ankyrin domain family member F

1

1

High-throughput

0.489

High

71364

F1712
Protein FAM171A2

1

1

High-throughput

0.489

High

86050

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

6

High-throughput

0.489

High

358907

AL1A1
Aldehyde dehydrogenase 1A1

1

1

High-throughput

0.489

High

366220

HPT
Haptoglobin

1

3

High-throughput

0.489

High

366238

HPTR
Haptoglobin-related protein

1

2

High-throughput

0.489

High

369409

A1AT
Alpha-1-antitrypsin

1

3

High-throughput

0.489

High

369519

AACT
Alpha-1-antichymotrypsin

1

3

High-throughput

0.489

High

369774

A2MG
Alpha-2-macroglobulin

1

2

High-throughput

0.489

High

388749

C1QB
Complement C1q subcomponent subunit B

1

2

High-throughput

0.489

High

388853

APOH
Beta-2-glycoprotein 1

1

3

High-throughput

0.489

High

389685

A1AG1
Alpha-1-acid glycoprotein 1

1

1

High-throughput

0.489

High

389769

FETUA
Alpha-2-HS-glycoprotein

1

1

High-throughput

0.489

High

390210

ALBU
Albumin

1

1

High-throughput

0.489

High

390309

VTDB
Vitamin D-binding protein

1

1

High-throughput

0.489

High

391165

HEMO
Hemopexin

1

3

High-throughput

0.489

High

399646

VTNC
Vitronectin

1

3

High-throughput

0.489

High

425234

IC1
Plasma protease C1 inhibitor

1

4

High-throughput

0.489

High

464480

TSP1
Thrombospondin-1

1

1

High-throughput

0.489

High

469452

ELNE
Neutrophil elastase

1

5

High-throughput

0.489

High

472364

CFAH
Complement factor H

1

3

High-throughput

0.489

High

575807

MMP9
Matrix metalloproteinase-9

1

3

High-throughput

0.489

High

602998

BPI
Bactericidal permeability-increasing protein

1

2

High-throughput

0.489

High

624712

A1AG2
Alpha-1-acid glycoprotein 2

1

1

High-throughput

0.489

High

626035

ITIH2
Inter-alpha-trypsin inhibitor heavy chain H2

1

2

High-throughput

0.489

High

626059

ITIH1
Inter-alpha-trypsin inhibitor heavy chain H1

1

2

High-throughput

0.489

High

653764

MMP8
Neutrophil collagenase

1

3

High-throughput

0.489

High

682649

S100P
Protein S100-P

1

1

High-throughput

0.489

High

721536

ILEU
Leukocyte elastase inhibitor

1

3

High-throughput

0.489

High

868108

AL1A3
Retinaldehyde dehydrogenase 3

1

1

High-throughput

0.489

High

1326487

BPIB2
BPI fold-containing family B member 2

1

2

High-throughput

0.489

High

1351349

BPIB1
BPI fold-containing family B member 1

1

3

High-throughput

0.489

High

1369797

RAD50
DNA repair protein RAD50

1

2

High-throughput

0.489

High

1445826

BPIA1
BPI fold-containing family A member 1

1

1

High-throughput

0.489

High

1460843

DD19B
ATP-dependent RNA helicase DDX19B

1

1

High-throughput

0.489

High

1460845

FCGBP
IgGFc-binding protein

1

2

High-throughput

0.489

High

989816

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

20

High-throughput

0.479

High

379146

IGKC
Immunoglobulin kappa constant

1

6

High-throughput

0.445

High

379319

IGHG1
Immunoglobulin heavy constant gamma 1

1

8

High-throughput

0.445

High

379409

IGHG2
Immunoglobulin heavy constant gamma 2

1

8

High-throughput

0.445

High

379444

IGHG3
Immunoglobulin heavy constant gamma 3

1

8

High-throughput

0.445

High

379584

IGHM
Immunoglobulin heavy constant mu

1

6

High-throughput

0.445

High

379721

IGHA1
Immunoglobulin heavy constant alpha 1

1

7

High-throughput

0.445

High

379785

IGHA2
Immunoglobulin heavy constant alpha 2

1

8

High-throughput

0.445

High

476058

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

20

High-throughput

0.445

High

501878

CO4B
Complement C4-B

1

2

High-throughput

0.445

High

1022245

MUC5A
Mucin-5AC

1

2

High-throughput

0.445

High

1040982

GNA12
Guanine nucleotide-binding protein subunit alpha-12

1

20

High-throughput

0.445

High

897423

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.426

High

445468

APOA4
Apolipoprotein A-IV

1

1

High-throughput

0.407

High

930380

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

1

High-throughput

0.407

High

1103672

PHLP
Phosducin-like protein

1

11

High-throughput

0.407

High

1452140

KCTD5
BTB/POZ domain-containing protein KCTD5

1

12

High-throughput

0.407

High

892961

MRE11
Double-strand break repair protein MRE11

2

0

High-throughput

0.313

High

378727

IGJ
Immunoglobulin J chain

1

0

High-throughput

0.279

Low

387575

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.279

Low

388592

SAMP
Serum amyloid P-component

1

0

High-throughput

0.279

Low

389896

TTHY
Transthyretin

1

0

High-throughput

0.279

Low

425758

PERM
Myeloperoxidase

1

0

High-throughput

0.279

Low

533795

CLUS
Clusterin

1

0

High-throughput

0.279

Low

595636

H15
Histone H1.5

1

0

High-throughput

0.279

Low

627898

TCO1
Transcobalamin-1

1

0

High-throughput

0.279

Low

671872

ZA2G
Zinc-alpha-2-glycoprotein

1

0

High-throughput

0.279

Low

833221

MNDA
Myeloid cell nuclear differentiation antigen

1

0

High-throughput

0.279

Low

914165

HXK3
Hexokinase-3

1

0

High-throughput

0.279

Low

963245

LYSC
Lysozyme C

1

0

High-throughput

0.279

Low

999425

HBB
Hemoglobin subunit beta

1

0

High-throughput

0.279

Low

1009746

NGAL
Neutrophil gelatinase-associated lipocalin

1

0

High-throughput

0.279

Low

1122782

DPOA2
DNA polymerase alpha subunit B

1

0

High-throughput

0.279

Low

1157315

PROL4
Proline-rich protein 4

1

0

High-throughput

0.279

Low

1242805

LEG1H
Protein LEG1 homolog

1

0

High-throughput

0.279

Low

1403179

INT14
Integrator complex subunit 14

1

0

High-throughput

0.279

Low

1451582

UCKL1
Uridine-cytidine kinase-like 1

1

0

High-throughput

0.279

Low

1459595

DMBT1
Scavenger receptor cysteine-rich domain-containing protein DMBT1

1

0

High-throughput

0.279

Low

1460842

PADI4
Protein-arginine deiminase type-4

1

0

High-throughput

0.279

Low

1460844

EXOG
Nuclease EXOG, mitochondrial

1

0

High-throughput

0.279

Low

1102683

MTA1
Metastasis-associated protein MTA1

1

0

High-throughput

0.249

Low

908795

MAT1
CDK-activating kinase assembly factor MAT1

1

0

High-throughput

0.232

Low

1452606

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025