HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: RBM14 (Q96PK6)
RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein)
Gene: RBM14

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21182205
Identification Methods	affinity chromatography technology, cosedimentation through density gradient
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex GO:0005737 - cytoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 669
+	Hs
		370350 ESR1_HUMAN (1-595): 0: 599: 100.00		RBM4_HUMAN (1-349): 9.22e-63: 214: 27.22
+	Hs
		370304 ESR1_HUMAN (1-595): 0: 599: 100.00		RBM4B_HUMAN (1-349): 1.8e-61: 210: 28.37
+	Hs
		370175 ESR1_HUMAN (1-595): 0: 599: 100.00		MSI2H_HUMAN (2-292): 1.37e-51: 183: 18.01
+	Hs
		368886 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP1_HUMAN (3-538): 5.24e-33: 137: 13.49
+	Hs
		370176 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP5_HUMAN (3-169): 2.16e-17: 86.5: 26.53
+	Hs
		369739 ESR1_HUMAN (1-595): 0: 599: 100.00		PAP1L_HUMAN (71-151): 4.63e-10: 64.6: 20.23
+	Hs
		369534 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP4_HUMAN (71-151): 5.98e-10: 64.2: 23.60
+	Hs
		370422 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP3_HUMAN (71-151): 1.96e-09: 62.7: 21.35
+	Hs
		1269400 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		RBM14_HUMAN (1-669): 4.16e-69: 239: 100.00
+	Hs
		1269462 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		RBM4B_HUMAN (1-349): 1.8e-61: 210: 28.37
+	Hs
		377606 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		RBM14_HUMAN (1-669): 4.16e-69: 239: 100.00
+	Hs
		377649 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		RBM4_HUMAN (1-349): 9.22e-63: 214: 27.22
+	Hs
		1269332 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PABP5_HUMAN (3-169): 2.16e-17: 86.5: 26.53
+	Hs
		1119140 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PAP1L_HUMAN (71-151): 4.63e-10: 64.6: 20.23
+	Hs
		1031409 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PABP4_HUMAN (71-151): 5.98e-10: 64.2: 23.60
+	Hs
		1269600 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PABP3_HUMAN (71-151): 1.96e-09: 62.7: 21.35
+	Hs
		516359 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		PABP1_HUMAN (3-538): 5.24e-33: 137: 13.49
+	Hs
		377286 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		ELAV2_HUMAN (4-154): 1.38e-16: 83.8: 25.15
+	Hs
		782537 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		PABP4_HUMAN (71-151): 5.98e-10: 64.2: 23.60
+	Hs
		611434 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		PABP4_HUMAN (71-151): 5.98e-10: 64.2: 23.60