Protein: CYTS
Cystatin-S (Cystatin-4) (Cystatin-SA-III) (Salivary acidic protein 1)

Gene: CYTS, CST4
Organism: Homo sapiens
Interactions: 96
UniProt ID: P01036

Gene Ontology (top 5):
GO:0001580 - detection of chemical stimulus involved in sensory perception of bitter taste
GO:0004869 - cysteine-type endopeptidase inhibitor activity
GO:0005615 - extracellular space
GO:0005737 - cytoplasm
GO:0031982 - vesicle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

370051

CYTN
Cystatin-SN

3

2

Small-scale

0.861

High

134461

CCRL2
C-C chemokine receptor-like 2

3

4

High-throughput

0.667

High

370072

RCAN2
Calcipressin-2

3

5

High-throughput

0.667

High

370096

UBTD2
Ubiquitin domain-containing protein 2

3

1

High-throughput

0.667

High

370052

FRIH
Ferritin heavy chain

2

3

High-throughput

0.628

High

370063

ARP3
Actin-related protein 3

2

1

High-throughput

0.628

High

370119

GKN1
Gastrokine-1

2

1

High-throughput

0.628

High

292283

B3GL1
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

3

4

High-throughput

0.609

High

370059

KI2S2
Killer cell immunoglobulin-like receptor 2DS2

3

3

High-throughput

0.609

High

370062

UCP2
Dicarboxylate carrier SLC25A8

3

7

High-throughput

0.609

High

370066

TF2B
Transcription initiation factor IIB

3

2

High-throughput

0.609

High

370085

APLF
Aprataxin and PNK-like factor

3

1

High-throughput

0.609

High

370124

UBQL2
Ubiquilin-2

2

1

High-throughput

0.606

High

370122

DIC
Mitochondrial dicarboxylate carrier

3

7

High-throughput

0.599

High

370123

DPOLL
DNA polymerase lambda

3

1

High-throughput

0.599

High

168947

QCR8
Cytochrome b-c1 complex subunit 8

2

1

High-throughput

0.574

High

318560

RHBT1
Rho-related BTB domain-containing protein 1

2

3

High-throughput

0.574

High

370060

EFTS
Elongation factor Ts, mitochondrial

2

1

High-throughput

0.574

High

370065

RUXF
Small nuclear ribonucleoprotein F

2

2

High-throughput

0.574

High

370076

PKHG6
Pleckstrin homology domain-containing family G member 6

2

3

High-throughput

0.574

High

370081

HBM
Hemoglobin subunit mu

2

6

High-throughput

0.574

High

370089

FRMD1
FERM domain-containing protein 1

2

3

High-throughput

0.574

High

370090

ZN491
Zinc finger protein 491

2

2

High-throughput

0.574

High

370092

NPB
Neuropeptide B

2

1

High-throughput

0.574

High

370105

ESIP1
Epithelial-stromal interaction protein 1

2

1

High-throughput

0.574

High

370106

SNX27
Sorting nexin-27

2

2

High-throughput

0.574

High

370115

DDX31
ATP-dependent DNA helicase DDX31

2

3

High-throughput

0.574

High

370118

TNR19
Tumor necrosis factor receptor superfamily member 19

2

2

High-throughput

0.574

High

370095

KCNG4
Voltage-gated potassium channel regulatory subunit KCNG4

2

2

High-throughput

0.558

High

178881

SCAM2
Secretory carrier-associated membrane protein 2

1

2

High-throughput

0.536

High

210642

KLK10
Kallikrein-10

1

3

High-throughput

0.536

High

279094

ULK1
Serine/threonine-protein kinase ULK1

1

2

High-throughput

0.536

High

366560

CFAB
Complement factor B

1

3

High-throughput

0.536

High

370054

CRF
Corticoliberin

1

2

High-throughput

0.536

High

370058

UFO
Tyrosine-protein kinase receptor UFO

1

6

High-throughput

0.536

High

370061

RCAN1
Calcipressin-1

1

5

High-throughput

0.536

High

370067

KPCE
Protein kinase C epsilon type

1

1

High-throughput

0.536

High

370069

DAZ2
Deleted in azoospermia protein 2

1

2

High-throughput

0.536

High

370070

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

1

High-throughput

0.536

High

370074

STK11
Serine/threonine-protein kinase STK11

1

2

High-throughput

0.536

High

370082

LRC8E
Volume-regulated anion channel subunit LRRC8E

1

1

High-throughput

0.536

High

370087

COMD1
COMM domain-containing protein 1

1

2

High-throughput

0.536

High

370097

CHAC2
Glutathione-specific gamma-glutamylcyclotransferase 2

1

1

High-throughput

0.536

High

370100

ITLN2
Intelectin-2

1

1

High-throughput

0.536

High

370110

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

3

High-throughput

0.536

High

370111

SRRT
Serrate RNA effector molecule homolog

1

1

High-throughput

0.536

High

370114

GREM2
Gremlin-2

1

1

High-throughput

0.536

High

370126

NXT1
NTF2-related export protein 1

1

1

High-throughput

0.536

High

282645

E2F6
Transcription factor E2F6

1

2

High-throughput

0.489

High

284780

TADA3
Transcriptional adapter 3

1

1

High-throughput

0.489

High

321796

ABCA8
ABC-type organic anion transporter ABCA8

1

1

High-throughput

0.489

High

370055

HBAT
Hemoglobin subunit theta-1

1

6

High-throughput

0.489

High

370064

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

1

3

High-throughput

0.489

High

370068

RING1
E3 ubiquitin-protein ligase RING1

1

1

High-throughput

0.489

High

370073

COG2
Conserved oligomeric Golgi complex subunit 2

1

1

High-throughput

0.489

High

370080

AKND1
Protein AKNAD1

1

2

High-throughput

0.489

High

370083

TCF23
Transcription factor 23

1

1

High-throughput

0.489

High

370086

NKAP
NF-kappa-B-activating protein

1

2

High-throughput

0.489

High

370088

CJ053
UPF0728 protein C10orf53

1

1

High-throughput

0.489

High

370098

RN141
RING finger protein 141

1

1

High-throughput

0.489

High

370101

CRGN
Gamma-crystallin N

1

2

High-throughput

0.489

High

370104

DISP1
Protein dispatched homolog 1

1

1

High-throughput

0.489

High

370108

CML1
Chemerin-like receptor 1

1

4

High-throughput

0.489

High

370112

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

1

High-throughput

0.489

High

370121

FKB14
Peptidyl-prolyl cis-trans isomerase FKBP14

1

4

High-throughput

0.489

High

370127

COR1C
Coronin-1C

1

2

High-throughput

0.489

High

85937

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

1

High-throughput

0.479

High

293009

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

370053

SODM
Superoxide dismutase [Mn], mitochondrial

1

1

High-throughput

0.479

High

370057

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

370071

CUL4A
Cullin-4A

1

2

High-throughput

0.479

High

370084

KCC1D
Calcium/calmodulin-dependent protein kinase type 1D

1

1

High-throughput

0.479

High

342710

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

370103

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.458

High

370117

VPP4
V-type proton ATPase 116 kDa subunit a 4

1

0

High-throughput

0.426

High

76291

B4DLN1
Mitochondrial dicarboxylate carrier

1

5

High-throughput

0.407

High

370056

ECE2
Endothelin-converting enzyme 2

1

3

High-throughput

0.407

High

370079

Q5JQP4
DNA polymerase

1

1

High-throughput

0.407

High

370109

RSRP1
Arginine/serine-rich protein 1

1

1

High-throughput

0.407

High

370075

SNPC1
snRNA-activating protein complex subunit 1

2

0

High-throughput

0.318

High

67412

GOG8A
Golgin subfamily A member 8A

1

0

High-throughput

0.279

Low

253805

TPST2
Protein-tyrosine sulfotransferase 2

1

0

High-throughput

0.279

Low

298135

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.279

Low

335214

CXB5
Gap junction beta-5 protein

1

0

High-throughput

0.279

Low

370078

T176B
Transmembrane protein 176B

1

0

High-throughput

0.279

Low

370091

AT11C
Phospholipid-transporting ATPase IG

1

0

High-throughput

0.279

Low

370093

TTL
Tubulin--tyrosine ligase

1

0

High-throughput

0.279

Low

370094

LPD6B
Ly6/PLAUR domain-containing protein 6B

1

0

High-throughput

0.279

Low

370099

GIMA1
GTPase IMAP family member 1

1

0

High-throughput

0.279

Low

370102

PMEPA
Protein TMEPAI

1

0

High-throughput

0.279

Low

370120

CHST7
Carbohydrate sulfotransferase 7

1

0

High-throughput

0.279

Low

370116

MTD2L
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial

1

0

High-throughput

0.269

Low

370077

T10IP
Testis-specific protein 10-interacting protein

1

0

High-throughput

0.249

Low

370113

RN208
RING finger protein 208

1

0

Small-scale

0.249

Low

370125

ZNHI2
Zinc finger HIT domain-containing protein 2

1

0

High-throughput

0.249

Low

370107

CFA54
Cilia- and flagella-associated protein 54

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025