HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: TAOK2 (Q9UL54)
Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2)
Gene: TAOK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31527615, unassigned1953
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 1235
+	Hs
		1269904 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TAOK2_HUMAN (1-1235): 0: 1173: 100.00
+	Hs
		370819 ESR1_HUMAN (1-595): 0: 599: 100.00		MRCKB_HUMAN (9-950): 1.39e-142: 475: 16.04
+	Hs
		369789 ESR1_HUMAN (1-595): 0: 599: 100.00		MRCKA_HUMAN (9-950): 1.11e-132: 447: 16.40
+	Hs
		369024 ESR1_HUMAN (1-595): 0: 599: 100.00		MARK3_HUMAN (2-668): 6.06e-135: 431: 16.57
+	Hs
		1270038 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MRCKB_HUMAN (9-950): 1.39e-142: 475: 16.04
+	Hs
		647937 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MARK3_HUMAN (2-668): 6.06e-135: 431: 16.57
+	Hs
		377817 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		SIK3_HUMAN (8-967): 2.08e-148: 483: 15.57
+	Hs
		659748 RXRB_HUMAN (144-549): 1.9e-111: 345: 27.64		MRCKB_HUMAN (9-950): 1.39e-142: 475: 16.04
+	Hs
		369519 ESR1_HUMAN (1-595): 0: 599: 100.00		PAK1_HUMAN (23-302): 1.03e-49: 187: 40.91
+	Mm
		103562 ESR1_MOUSE (1-595): 0: 570: 88.98		G5E884_MOUSE (23-302): 6.02e-50: 188: 40.91
+	Hs
		1269807 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		STK26_HUMAN (23-298): 1.39e-106: 343: 42.55
+	Hs
		611430 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		STK3_HUMAN (15-431): 8.58e-112: 360: 31.29
+	Hs
		611427 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		STK4_HUMAN (24-433): 2.72e-111: 359: 32.78
+	Hs
		148263 ESR1_HUMAN (1-595): 0: 599: 100.00		CTRO_HUMAN (350-914): 3.39e-10: 67.2: 10.41
+	Hs
		487504 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		MRCKA_HUMAN (9-950): 1.11e-132: 447: 16.40
+	Hs
		149132 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		CTRO_HUMAN (350-914): 3.39e-10: 67.2: 10.41