HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: C170B (Q9Y4F5)
Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B)
Gene: CEP170B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31527615, unassigned1953
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 1589
+	Hs
		1270019 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		C170B_HUMAN (1-1589): 0: 654: 100.00
+	Hs
		1131790 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		CE170_HUMAN (1-1555): 2.86e-117: 408: 29.19
+	Hs
		370040 ESR1_HUMAN (1-595): 0: 599: 100.00		KMT2C_HUMAN (117-1381): 3.46e-38: 159: 10.42
+	Hs
		368927 ESR1_HUMAN (1-595): 0: 599: 100.00		MUC1_HUMAN (122-1134): 1.76e-27: 123: 11.70
+	Hs
		369607 ESR1_HUMAN (1-595): 0: 599: 100.00		MDC1_HUMAN (111-750): 1.81e-19: 97.9: 8.75
+	Hs
		370728 ESR1_HUMAN (1-595): 0: 599: 100.00		SRRM2_HUMAN (99-1578): 2.66e-17: 91: 10.59
+	Hs
		370263 ESR1_HUMAN (1-595): 0: 599: 100.00		MINT_HUMAN (90-1589): 5.24e-13: 76.7: 9.37
+	Hs
		369815 ESR1_HUMAN (1-595): 0: 599: 100.00		NIPBL_HUMAN (306-1291): 1.68e-11: 71.6: 12.32
+	Hs
		370105 ESR1_HUMAN (1-595): 0: 599: 100.00		TITIN_HUMAN (97-999): 5.28e-11: 70.2: 8.87
+	Hs
		1243831 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		KMT2C_HUMAN (117-1381): 3.46e-38: 159: 10.42
+	Hs
		554348 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MUC1_HUMAN (122-1134): 1.76e-27: 123: 11.70
+	Hs
		782595 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		KMT2C_HUMAN (117-1381): 3.46e-38: 159: 10.42
+	Hs
		1056909 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MDC1_HUMAN (111-750): 1.81e-19: 97.9: 8.75
+	Hs
		1269948 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SRRM2_HUMAN (99-1578): 2.66e-17: 91: 10.59
+	Hs
		1154059 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		NIPBL_HUMAN (306-1291): 1.68e-11: 71.6: 12.32
+	Hs
		1264774 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TITIN_HUMAN (97-999): 5.28e-11: 70.2: 8.87
+	Hs
		1270066 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PCLO_HUMAN (1055-1586): 9.43e-10: 66: 6.77
+	Hs
		782640 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		MINT_HUMAN (90-1589): 5.24e-13: 76.7: 9.37
+	Hs
		782571 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		NIPBL_HUMAN (306-1291): 1.68e-11: 71.6: 12.32
+	Hs
		231019 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		L37A3_HUMAN (377-1087): 2.72e-10: 67.8: 13.90