Protein: CREB5
Cyclic AMP-responsive element-binding protein 5 (CREB-5) (cAMP-responsive element-binding protein 5) (cAMP-response element-binding protein A) (CRE-BPa)

Gene: CREB5
Organism: Homo sapiens
Interactions: 173
UniProt ID: Q02930

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003700 - DNA-binding transcription factor activity
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

584083

FOSL2
Fos-related antigen 2

8

20

High-throughput

0.974

High

429757

JUN
Transcription factor Jun

8

19

Small-scale

0.973

High

370636

FOS
Protein c-Fos

6

20

High-throughput

0.947

High

584012

FOSL1
Fos-related antigen 1

4

19

High-throughput

0.909

High

1039825

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

4

20

High-throughput

0.902

High

166519

BACH1
Transcription regulator protein BACH1

4

16

High-throughput

0.892

High

583538

ATF2
Cyclic AMP-dependent transcription factor ATF-2

4

18

High-throughput

0.892

High

605073

JUND
Transcription factor JunD

3

17

High-throughput

0.861

High

605252

ATF7
Cyclic AMP-dependent transcription factor ATF-7

3

18

High-throughput

0.861

High

921037

FOSB
Protein FosB

3

20

High-throughput

0.858

High

603641

JUNB
Transcription factor JunB

3

19

High-throughput

0.855

High

1039731

CREB5
Cyclic AMP-responsive element-binding protein 5

3

17

Small-scale

0.849

High

1039788

JDP2
Jun dimerization protein 2

2

19

High-throughput

0.783

High

936541

AF17
Protein AF-17

4

7

High-throughput

0.698

High

921331

CEBPG
CCAAT/enhancer-binding protein gamma

1

17

High-throughput

0.691

High

1039816

BACH2
Transcription regulator protein BACH2

1

16

High-throughput

0.691

High

1039797

MDFI
MyoD family inhibitor

4

0

High-throughput

0.677

High

303127

RGS20
Regulator of G-protein signaling 20

3

3

High-throughput

0.675

High

351527

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

3

7

High-throughput

0.675

High

1039799

KIFC3
Kinesin-like protein KIFC3

3

2

High-throughput

0.675

High

1039791

RBPMS
RNA-binding protein with multiple splicing

3

0

High-throughput

0.646

High

1039736

TRAF2
TNF receptor-associated factor 2

2

3

High-throughput

0.639

High

1039812

KRA32
Keratin-associated protein 3-2

4

1

High-throughput

0.637

High

1039836

ARI1
E3 ubiquitin-protein ligase ARIH1

2

8

High-throughput

0.628

High

606660

CEBPB
CCAAT/enhancer-binding protein beta

1

20

High-throughput

0.618

High

221344

SPY1
Protein sprouty homolog 1

3

4

High-throughput

0.616

High

694327

CO8A1
Collagen alpha-1(VIII) chain

3

2

High-throughput

0.616

High

950454

KR108
Keratin-associated protein 10-8

3

20

High-throughput

0.616

High

950746

KR109
Keratin-associated protein 10-9

3

20

High-throughput

0.616

High

1039762

K1C40
Keratin, type I cytoskeletal 40

3

5

High-throughput

0.616

High

1039773

ATL4
ADAMTS-like protein 4

3

1

High-throughput

0.616

High

1039798

KR412
Keratin-associated protein 4-12

3

20

High-throughput

0.616

High

1039806

KRA92
Keratin-associated protein 9-2

3

20

High-throughput

0.616

High

1039811

KRA42
Keratin-associated protein 4-2

3

20

High-throughput

0.616

High

1039784

TRI42
Tripartite motif-containing protein 42

2

8

High-throughput

0.615

High

253012

LMX1B
LIM homeobox transcription factor 1-beta

2

5

High-throughput

0.606

High

299823

SNPC5
snRNA-activating protein complex subunit 5

2

1

High-throughput

0.606

High

426074

PPB1
Alkaline phosphatase, placental type

2

1

High-throughput

0.606

High

654491

FBLN1
Fibulin-1

2

7

High-throughput

0.606

High

885220

HXA1
Homeobox protein Hox-A1

2

7

High-throughput

0.606

High

1039735

TP53B
TP53-binding protein 1

2

5

High-throughput

0.606

High

1039738

FHL3
Four and a half LIM domains protein 3

2

4

High-throughput

0.606

High

1039739

K1H1
Keratin, type I cuticular Ha1

2

5

High-throughput

0.606

High

1039756

INT11
Integrator complex subunit 11

2

2

High-throughput

0.606

High

1039765

SPOPL
Speckle-type POZ protein-like

2

5

High-throughput

0.606

High

1039793

AJUBA
LIM domain-containing protein ajuba

2

3

High-throughput

0.606

High

1039802

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

2

7

High-throughput

0.606

High

1039819

PRD14
PR domain zinc finger protein 14

2

1

High-throughput

0.606

High

1039820

RN208
RING finger protein 208

2

1

High-throughput

0.606

High

1039826

APC11
Anaphase-promoting complex subunit 11

2

3

High-throughput

0.606

High

1039827

WWOX
WW domain-containing oxidoreductase

2

1

High-throughput

0.606

High

1039832

RGS17
Regulator of G-protein signaling 17

2

2

High-throughput

0.606

High

1039834

AKP8L
A-kinase anchor protein 8-like

2

1

High-throughput

0.606

High

685837

KRA59
Keratin-associated protein 5-9

3

20

High-throughput

0.604

High

1039833

PP13
Galactoside-binding soluble lectin 13

3

1

High-throughput

0.604

High

1039779

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

3

5

High-throughput

0.603

High

1039763

Q6FG41
Protein c-Fos

1

20

High-throughput

0.594

High

950232

KR107
Keratin-associated protein 10-7

2

20

High-throughput

0.586

High

70177

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.580

High

186254

SIVA
Apoptosis regulatory protein Siva

2

0

High-throughput

0.580

High

571933

TRI27
Zinc finger protein RFP

2

0

High-throughput

0.580

High

1037097

ID3
DNA-binding protein inhibitor ID-3

2

0

High-throughput

0.580

High

1039753

KPRP
Keratinocyte proline-rich protein

2

0

High-throughput

0.580

High

1039792

TSR2
Pre-rRNA-processing protein TSR2 homolog

2

0

High-throughput

0.580

High

1039794

ZN363
RING finger and CHY zinc finger domain-containing protein 1

2

0

High-throughput

0.580

High

1039796

LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor

2

0

High-throughput

0.580

High

1039824

UNKL
Putative E3 ubiquitin-protein ligase UNKL

2

0

High-throughput

0.580

High

1039830

ZMAT5
Zinc finger matrin-type protein 5

2

0

High-throughput

0.580

High

1039835

ZN330
Zinc finger protein 330

2

0

High-throughput

0.580

High

1039776

NT2NA
Notch homolog 2 N-terminal-like protein A

2

2

High-throughput

0.578

High

1039761

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

2

6

High-throughput

0.574

High

221117

SPY2
Protein sprouty homolog 2

1

4

High-throughput

0.573

High

618022

K1C15
Keratin, type I cytoskeletal 15

1

4

High-throughput

0.573

High

783243

TRI23
E3 ubiquitin-protein ligase TRIM23

1

4

High-throughput

0.573

High

1039741

TRIP6
Thyroid receptor-interacting protein 6

1

3

High-throughput

0.573

High

1039751

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

5

High-throughput

0.573

High

1039831

RIM3A
RIMS-binding protein 3A

1

2

High-throughput

0.573

High

950049

KR105
Keratin-associated protein 10-5

2

20

High-throughput

0.558

High

950924

KR10B
Keratin-associated protein 10-11

2

20

High-throughput

0.558

High

49494

CIB4
Calcium and integrin-binding family member 4

2

5

High-throughput

0.553

High

165173

TSN4
Tetraspanin-4

2

2

High-throughput

0.553

High

221414

SPY3
Protein sprouty homolog 3

2

4

High-throughput

0.553

High

227212

KRT86
Keratin, type II cuticular Hb6

2

4

High-throughput

0.553

High

626956

FST
Follistatin

2

1

High-throughput

0.553

High

665922

IBP6
Insulin-like growth factor-binding protein 6

2

1

High-throughput

0.553

High

948710

KR10A
Keratin-associated protein 10-10

2

20

High-throughput

0.553

High

1007470

KRT83
Keratin, type II cuticular Hb3

2

4

High-throughput

0.553

High

1007510

KRT85
Keratin, type II cuticular Hb5

2

4

High-throughput

0.553

High

1039752

GT253
Inactive glycosyltransferase 25 family member 3

2

1

High-throughput

0.553

High

1039766

KR511
Keratin-associated protein 5-11

2

20

High-throughput

0.553

High

1039767

KRA57
Keratin-associated protein 5-7

2

19

High-throughput

0.553

High

1039769

KRA54
Keratin-associated protein 5-4

2

16

High-throughput

0.553

High

1039783

KRA13
Keratin-associated protein 1-3

2

20

High-throughput

0.553

High

1039803

KRA98
Keratin-associated protein 9-8

2

20

High-throughput

0.553

High

1039805

KRA93
Keratin-associated protein 9-3

2

20

High-throughput

0.553

High

1039808

KRA41
Keratin-associated protein 4-1

2

20

High-throughput

0.553

High

1039809

KRA45
Keratin-associated protein 4-5

2

20

High-throughput

0.553

High

1039810

KRA44
Keratin-associated protein 4-4

2

20

High-throughput

0.553

High

1039813

KRA31
Keratin-associated protein 3-1

2

1

High-throughput

0.553

High

1039815

KRA15
Keratin-associated protein 1-5

2

20

High-throughput

0.553

High

1039818

SPY4
Protein sprouty homolog 4

2

4

High-throughput

0.553

High

230009

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

5

High-throughput

0.536

High

1039737

CTBP1
C-terminal-binding protein 1

1

4

High-throughput

0.536

High

1039740

ZMY11
Zinc finger MYND domain-containing protein 11

1

5

High-throughput

0.536

High

1039775

CENPQ
Centromere protein Q

1

6

High-throughput

0.536

High

1039823

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.536

High

1039828

ANFY1
Rabankyrin-5

1

2

High-throughput

0.536

High

1039829

FBLN5
Fibulin-5

1

7

High-throughput

0.536

High

949687

KR101
Keratin-associated protein 10-1

2

20

High-throughput

0.533

High

1039804

KRA94
Keratin-associated protein 9-4

1

20

High-throughput

0.523

High

1039817

TSG10
Testis-specific gene 10 protein

1

6

High-throughput

0.523

High

705310

GRN
Progranulin

1

0

High-throughput

0.493

High

926954

ATX3
Ataxin-3

1

0

High-throughput

0.493

High

1039742

INSY1
Inhibitory synaptic factor 1

1

3

High-throughput

0.489

High

227507

SPOP
Speckle-type POZ protein

1

5

Small-scale

0.481

High

1039777

R144B
E3 ubiquitin-protein ligase RNF144B

1

6

High-throughput

0.481

High

136877

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

1

High-throughput

0.479

High

142949

NFIB
Nuclear factor 1 B-type

1

19

High-throughput

0.479

High

473926

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

799013

BRCA1
Breast cancer type 1 susceptibility protein

1

9

High-throughput

0.479

High

1004466

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

1032909

EWS
RNA-binding protein EWS

1

4

High-throughput

0.479

High

1039734

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1039785

SLX4
Structure-specific endonuclease subunit SLX4

1

11

High-throughput

0.479

High

1039789

ESR2
Estrogen receptor beta

1

16

High-throughput

0.479

High

1039795

CIC
Protein capicua homolog

1

14

High-throughput

0.479

High

109391

G5E9A7
DM1 locus, WD repeat containing

1

10

High-throughput

0.470

High

186901

GPR37
Prosaposin receptor GPR37

1

3

High-throughput

0.470

High

516993

NT2NC
Notch homolog 2 N-terminal-like protein C

1

3

High-throughput

0.470

High

1039733

Q08AG9
Steroid 21-hydroxylase

1

3

High-throughput

0.470

High

1039814

KRA24
Keratin-associated protein 2-4

1

20

High-throughput

0.470

High

508

NBPFJ
NBPF family member NBPF19

1

4

High-throughput

0.439

High

475201

CP21A
Steroid 21-hydroxylase

1

3

High-throughput

0.439

High

505314

KRA23
Keratin-associated protein 2-3

1

20

High-throughput

0.439

High

949854

KR103
Keratin-associated protein 10-3

1

20

High-throughput

0.439

High

1039732

KRA11
Keratin-associated protein 1-1

1

20

High-throughput

0.439

High

1039770

KRA53
Keratin-associated protein 5-3

1

20

High-throughput

0.439

High

1039807

KR411
Keratin-associated protein 4-11

1

20

High-throughput

0.439

High

1039768

KRA56
Keratin-associated protein 5-6

3

0

High-throughput

0.352

High

192077

PA2GX
Group 10 secretory phospholipase A2

2

0

High-throughput

0.316

High

220236

FRS3
Fibroblast growth factor receptor substrate 3

2

0

High-throughput

0.316

High

532137

RET3
Retinol-binding protein 3

2

0

High-throughput

0.316

High

949532

KR123
Keratin-associated protein 12-3

2

0

High-throughput

0.316

High

1039743

KR192
Keratin-associated protein 19-2

2

0

High-throughput

0.316

High

1039744

KRA61
Keratin-associated protein 6-1

2

0

High-throughput

0.316

High

1039745

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.316

High

1039747

KR196
Keratin-associated protein 19-6

2

0

High-throughput

0.316

High

1039748

KR195
Keratin-associated protein 19-5

2

0

High-throughput

0.316

High

1039754

LCE1C
Late cornified envelope protein 1C

2

0

High-throughput

0.316

High

1039757

LCE4A
Late cornified envelope protein 4A

2

0

High-throughput

0.316

High

1039758

LCE2A
Late cornified envelope protein 2A

2

0

High-throughput

0.316

High

1039759

LCE2C
Late cornified envelope protein 2C

2

0

High-throughput

0.316

High

1039760

LCE5A
Late cornified envelope protein 5A

2

0

High-throughput

0.316

High

1039764

NADE
Glutamine-dependent NAD(+) synthetase

2

0

High-throughput

0.316

High

1039771

UFSP1
Ufm1-specific protease 1

2

0

High-throughput

0.316

High

1039772

CDPF1
Cysteine-rich DPF motif domain-containing protein 1

2

0

High-throughput

0.316

High

1039774

KRA52
Keratin-associated protein 5-2

2

0

High-throughput

0.316

High

1039778

KR193
Keratin-associated protein 19-3

2

0

High-throughput

0.316

High

1039780

SPT12
Spermatogenesis-associated protein 12

2

0

High-throughput

0.316

High

1039781

KRA81
Keratin-associated protein 8-1

2

0

High-throughput

0.316

High

1039782

KRA71
Keratin-associated protein 7-1

2

0

High-throughput

0.316

High

1039790

PCSK5
Proprotein convertase subtilisin/kexin type 5

2

0

High-throughput

0.316

High

1039801

CNFN
Cornifelin

2

0

High-throughput

0.316

High

1039821

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

2

0

High-throughput

0.316

High

1039822

MMAD
Cobalamin trafficking protein CblD

2

0

High-throughput

0.316

High

1039750

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

2

0

High-throughput

0.304

High

1039746

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.268

Low

1039749

KR221
Keratin-associated protein 22-1

1

0

High-throughput

0.251

Low

1039755

LCE1F
Late cornified envelope protein 1F

1

0

High-throughput

0.251

Low

1039786

PRR22
Proline-rich protein 22

1

0

High-throughput

0.251

Low

1039787

SRB4D
Scavenger receptor cysteine-rich domain-containing group B protein

1

0

High-throughput

0.251

Low

1039800

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025