HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: RRAS (P10301)
Ras-related protein R-Ras (EC 3.6.5.-) (p23)
Gene: RRAS

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.845

Property	Details
Experiments	8002932, 10848612, 19805522
Identification Methods	two hybrid, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, Pkinase~Ras, RBD~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0007265 - Ras protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 648 Hs			1 218
+	Hs
		373993 RAF1_HUMAN (1-648): 0: 652: 100.00		RRAS2_HUMAN (42-218): 1.8e-88: 260: 66.85
+	Hs
		374007 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB1A_HUMAN (19-215): 1.94e-81: 243: 30.58
+	Hs
		374854 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB1B_HUMAN (22-215): 1.41e-79: 238: 30.69
+	Hs
		374003 RAF1_HUMAN (1-648): 0: 652: 100.00		RB11A_HUMAN (19-211): 4.72e-77: 232: 30.41
+	Hs
		373973 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB8A_HUMAN (22-218): 3.64e-76: 229: 27.89
+	Hs
		156089 RAF1_HUMAN (1-648): 0: 652: 100.00		RASM_HUMAN (21-199): 4.28e-56: 179: 56.11
+	Hs
		349052 RAF1_HUMAN (1-648): 0: 652: 100.00		RASH_HUMAN (42-217): 1.68e-56: 179: 53.41
+	Hs
		348461 RAF1_HUMAN (1-648): 0: 652: 100.00		RASN_HUMAN (42-218): 1.56e-55: 176: 51.98
+	Hs
		373983 RAF1_HUMAN (1-648): 0: 652: 100.00		RAP1B_HUMAN (30-208): 2.96e-55: 176: 50.00
+	Rn
		507685 RAF1_RAT (1-648): 0: 648: 98.30		RASH_RAT (42-217): 1.68e-56: 179: 53.41
+	Mm
		1142565 RAF1_MOUSE (1-648): 0: 647: 97.69		RASH_MOUSE (42-217): 1.68e-56: 179: 53.41
+	Hs
		349785 RAF1_HUMAN (1-648): 0: 652: 100.00		RASK_HUMAN (42-213): 5.55e-54: 172: 51.74
+	Hs
		373598 RAF1_HUMAN (1-648): 0: 652: 100.00		RALB_HUMAN (30-197): 8.3e-54: 172: 50.89
+	Hs
		374009 RAF1_HUMAN (1-648): 0: 652: 100.00		RAP1A_HUMAN (30-192): 5.18e-54: 172: 51.83
+	Rn
		442943 RAF1_RAT (1-648): 0: 648: 98.30		RASK_RAT (42-218): 3.67e-54: 173: 50.28
+	Mm
		699624 RAF1_MOUSE (1-648): 0: 647: 97.69		RASK_MOUSE (42-218): 3.67e-54: 173: 50.28
+	Hs
		156090 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		RASM_HUMAN (21-199): 4.28e-56: 179: 56.11
+	Hs
		349101 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		RASH_HUMAN (42-217): 1.68e-56: 179: 53.41
+	Hs
		348493 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		RASN_HUMAN (42-218): 1.56e-55: 176: 51.98
+	Hs
		349847 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		RASK_HUMAN (42-213): 5.55e-54: 172: 51.74