Protein: TIM16
Mitochondrial import inner membrane translocase subunit TIM16 (Mitochondria-associated granulocyte macrophage CSF-signaling molecule) (Presequence translocated-associated motor subunit PAM16)

Gene: TIM16, PAM16
Organism: Homo sapiens
Interactions: 108
UniProt ID: Q9Y3D7

Gene Ontology (top 5):
GO:0001405 - PAM complex, Tim23 associated import motor
GO:0001503 - ossification
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005744 - TIM23 mitochondrial import inner membrane translocase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1387250

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

5

4

Small-scale

0.722

High

1491211

DJC15
DnaJ homolog subfamily C member 15

3

4

Small-scale

0.671

High

1491209

TIM16
Mitochondrial import inner membrane translocase subunit TIM16

1

1

Small-scale

0.618

High

251274

RNBP6
Ran-binding protein 6

2

0

High-throughput

0.602

High

1405599

TI17A
Mitochondrial import inner membrane translocase subunit Tim17-A

2

2

Small-scale

0.584

High

1162636

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

257583

TI17B
Mitochondrial import inner membrane translocase subunit Tim17-B

1

2

Small-scale

0.536

High

1491210

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

0

High-throughput

0.513

High

349613

TSN15
Tetraspanin-15

1

1

High-throughput

0.489

High

622117

CD53
Leukocyte surface antigen CD53

1

1

High-throughput

0.489

High

1246519

BL1S2
Biogenesis of lysosome-related organelles complex 1 subunit 2

1

0

High-throughput

0.486

High

221695

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

1

Small-scale

0.479

High

282138

MPPB
Mitochondrial-processing peptidase subunit beta

1

2

High-throughput

0.479

High

287419

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

373580

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

856440

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.479

High

1083808

MPPA
Mitochondrial-processing peptidase subunit alpha

1

2

High-throughput

0.479

High

1161275

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.479

High

1273044

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

1

High-throughput

0.479

High

1337255

MCU
Calcium uniporter protein, mitochondrial

1

1

High-throughput

0.479

High

1381789

FAKD4
FAST kinase domain-containing protein 4

1

1

High-throughput

0.479

High

1383586

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

1401669

EFGM
Elongation factor G, mitochondrial

1

1

High-throughput

0.479

High

1428840

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

1432658

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

1451278

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

1

High-throughput

0.479

High

1459182

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

1491213

MTCH2
Mitochondrial carrier homolog 2

1

2

High-throughput

0.479

High

1232651

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

61695

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

66345

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.458

High

137853

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

275142

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

279988

CISY
Citrate synthase, mitochondrial

1

0

High-throughput

0.458

High

351053

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

829025

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

842044

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

852089

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

882968

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

980586

H4
Histone H4

1

0

High-throughput

0.458

High

1048769

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1058372

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1117890

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

1123493

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.458

High

1149654

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

1196953

MIX23
Protein MIX23

1

0

High-throughput

0.458

High

1217668

MARC1
Mitochondrial amidoxime-reducing component 1

1

0

High-throughput

0.458

High

1241372

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.458

High

1270685

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

1276383

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.458

High

1331325

S2529
Mitochondrial basic amino acids transporter

1

0

High-throughput

0.458

High

1352858

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1356905

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

0

High-throughput

0.458

High

1359207

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

0

High-throughput

0.458

High

1386063

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

0

High-throughput

0.458

High

1389944

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

0

High-throughput

0.458

High

1412490

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

1412626

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.458

High

1414131

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

1416592

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

1418947

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

1420439

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

0

High-throughput

0.458

High

1428778

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1431228

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

0

High-throughput

0.458

High

1432007

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

1432337

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

1434711

TFB2M
Dimethyladenosine transferase 2, mitochondrial

1

0

High-throughput

0.458

High

1435847

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1436152

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

1450479

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1451763

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

1453986

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

1491145

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

894261

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.439

High

406836

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

1138799

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.437

High

1340584

MFSD8
Major facilitator superfamily domain-containing protein 8

1

0

High-throughput

0.426

High

1462212

PCDAC
Protocadherin alpha-12

2

0

High-throughput

0.328

High

1406439

FEZ1
Fasciculation and elongation protein zeta-1

2

0

High-throughput

0.323

High

848593

MAGA8
Melanoma-associated antigen 8

2

0

High-throughput

0.313

High

1139306

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.299

High

1452561

FA13B
Protein FAM13B

2

0

High-throughput

0.298

High

470355

NEP
Neprilysin

1

0

High-throughput

0.279

Low

879821

NPY2R
Neuropeptide Y receptor type 2

1

0

High-throughput

0.279

Low

1363260

AQP3
Aquaporin-3

1

0

High-throughput

0.279

Low

130293

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.265

Low

906956

GPM6A
Neuronal membrane glycoprotein M6-a

1

0

High-throughput

0.265

Low

1340391

CEP70
Centrosomal protein of 70 kDa

1

0

High-throughput

0.265

Low

1458301

DNM3B
DNA

1

0

High-throughput

0.265

Low

1491212

MOFA1
MORF4 family-associated protein 1

1

0

High-throughput

0.265

Low

294570

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

375033

RASH
GTPase HRas

1

0

High-throughput

0.249

Low

377236

SOMA
Somatotropin

1

0

High-throughput

0.249

Low

937995

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.249

Low

1015933

RHOG
Rho-related GTP-binding protein RhoG

1

0

High-throughput

0.249

Low

1229786

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

1329402

TEX29
Testis-expressed protein 29

1

0

High-throughput

0.249

Low

1435250

ANTR1
Anthrax toxin receptor 1

1

0

High-throughput

0.249

Low

1438453

SACA1
Sperm acrosome membrane-associated protein 1

1

0

High-throughput

0.249

Low

1451714

DJC28
DnaJ homolog subfamily C member 28

1

0

High-throughput

0.249

Low

1459417

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1461932

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.249

Low

1490573

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

0

High-throughput

0.249

Low

844982

EAA2
Excitatory amino acid transporter 2

1

0

High-throughput

0.232

Low

1323790

S39AB
Zinc transporter ZIP11

1

0

High-throughput

0.232

Low

1383520

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

0

High-throughput

0.232

Low

1389635

SAAL1
Protein SAAL1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025