HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: MPIP1 (P30304)
M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A)
Gene: CDC25A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.866

Property	Details
Experiments	7744247, 9230211, 7644510
Identification Methods	pull down, affinity chromatography technology, experimental interaction detection, biochemical, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Pkinase~Rhodanese
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 524
+	Xl
		452154 RAF1_XENLA (1-648): 0: 597: 85.19		P79923_XENLA (25-524): 0: 613: 53.48
+	Hs
		373754 RAF1_HUMAN (1-648): 0: 652: 100.00		MPIP2_HUMAN (32-522): 0: 544: 43.02
+	Hs
		522807 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		MPIP1_HUMAN (1-524): 0: 723: 100.00
+	Hs
		673495 KSR1_HUMAN (138-648): 6.15e-108: 348: 24.61		MPIP2_HUMAN (32-522): 0: 544: 43.02
+	Hs
		673602 KSR1_HUMAN (138-648): 6.15e-108: 348: 24.61		MPIP3_HUMAN (31-523): 1.2e-156: 456: 34.46