Protein: MTDC
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)]

Gene: MTDC, MTHFD2
Organism: Homo sapiens
Interactions: 89
UniProt ID: P13995

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004477 - methenyltetrahydrofolate cyclohydrolase activity
GO:0004487 - methylenetetrahydrofolate dehydrogenase (NAD+) activity
GO:0004488 - methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

569337

MTD2L
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial

2

6

High-throughput

0.811

High

569345

NAGK
N-acetyl-D-glucosamine kinase

4

1

High-throughput

0.629

High

374375

RASH
GTPase HRas

3

2

High-throughput

0.604

High

569297

SRP09
Signal recognition particle 9 kDa protein

3

1

High-throughput

0.604

High

569288

ACADL
Long-chain specific acyl-CoA dehydrogenase, mitochondrial

2

0

High-throughput

0.602

High

569313

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

1

High-throughput

0.584

High

569306

TFCP2
Alpha-globin transcription factor CP2

2

1

High-throughput

0.574

High

569340

UBIP1
Upstream-binding protein 1

2

1

High-throughput

0.574

High

569317

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

3

High-throughput

0.552

High

569295

MAPK2
MAP kinase-activated protein kinase 2

2

1

High-throughput

0.549

High

484359

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

569324

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

569330

MACD1
ADP-ribose glycohydrolase MACROD1

1

0

High-throughput

0.513

High

569298

DAPK1
Death-associated protein kinase 1

1

5

High-throughput

0.489

High

569290

MYH9
Myosin-9

1

1

High-throughput

0.489

High

569304

CALD1
Caldesmon

1

2

High-throughput

0.489

High

569308

CUL3
Cullin-3

1

3

High-throughput

0.489

High

164237

NRP1
Neuropilin-1

1

1

High-throughput

0.479

High

240637

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

279638

CISY
Citrate synthase, mitochondrial

1

1

High-throughput

0.479

High

293142

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

470836

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

519043

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

532329

CH60
60 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.479

High

536411

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

569289

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

569292

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

569293

EFTS
Elongation factor Ts, mitochondrial

1

1

High-throughput

0.479

High

569294

IF2M
Translation initiation factor IF-2, mitochondrial

1

3

High-throughput

0.479

High

569296

EFTU
Elongation factor Tu, mitochondrial

1

2

High-throughput

0.479

High

569305

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

569312

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.479

High

569316

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.479

High

569320

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

569323

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

6

High-throughput

0.479

High

569329

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

569332

TR61B
tRNA

1

1

High-throughput

0.479

High

569333

BRD8
Bromodomain-containing protein 8

1

5

High-throughput

0.479

High

569334

MTG2
Mitochondrial ribosome-associated GTPase 2

1

2

High-throughput

0.479

High

569336

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

569341

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

281873

MPPB
Mitochondrial-processing peptidase subunit beta

1

0

High-throughput

0.458

High

569291

SYUA
Alpha-synuclein

1

0

Small-scale

0.458

High

569299

ATX3
Ataxin-3

1

0

Small-scale

0.458

High

569303

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

569309

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

569318

MIC10
MICOS complex subunit MIC10

1

0

Small-scale

0.458

High

569328

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

High-throughput

0.458

High

569331

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

569300

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.457

High

319357

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.437

High

340815

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

3

High-throughput

0.437

High

349772

SNAI1
Zinc finger protein SNAI1

1

2

High-throughput

0.437

High

371057

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.437

High

405745

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.437

High

563111

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.437

High

569286

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.437

High

569287

CRCM
Colorectal mutant cancer protein

1

3

High-throughput

0.437

High

569301

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.437

High

569302

RHOG
Rho-related GTP-binding protein RhoG

1

1

High-throughput

0.437

High

569307

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

3

High-throughput

0.437

High

569310

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.437

High

569311

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.437

High

569314

CL16A
Protein CLEC16A

1

1

High-throughput

0.437

High

569321

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

569326

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.437

High

569335

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

569339

ANLN
Anillin

1

2

High-throughput

0.437

High

569342

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.437

High

569343

UBQL2
Ubiquilin-2

1

1

High-throughput

0.437

High

569346

FZR1
Fizzy-related protein homolog

1

2

High-throughput

0.437

High

373753

RASN
GTPase NRas

1

2

High-throughput

0.407

High

569315

S39AC
Zinc transporter ZIP12

1

1

High-throughput

0.407

High

479195

THIK
3-ketoacyl-CoA thiolase, peroxisomal

2

0

High-throughput

0.318

High

184109

RER1
Protein RER1

1

0

High-throughput

0.279

Low

209464

SERA
D-3-phosphoglycerate dehydrogenase

1

0

High-throughput

0.279

Low

569322

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

569325

CMIP6
Ciliary microtubule inner protein 6

1

0

High-throughput

0.279

Low

569348

MB212
Protein mab-21-like 2

1

0

High-throughput

0.279

Low

569347

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

0

High-throughput

0.269

Low

569349

PARP3
Protein mono-ADP-ribosyltransferase PARP3

1

0

High-throughput

0.269

Low

385414

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.251

Low

193968

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.249

Low

439930

LCK
Tyrosine-protein kinase Lck

1

0

High-throughput

0.249

Low

569319

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.249

Low

569338

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.249

Low

569344

DS13B
Dual specificity protein phosphatase 13B

1

0

High-throughput

0.249

Low

213057

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.232

Low

569327

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025