HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: CDN2A (P42771)
Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
Gene: CDKN2A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	28205554
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007265 - Ras protein signal transduction GO:0008285 - negative regulation of cell population proliferation
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 156
+	Hs
		373839 RAF1_HUMAN (1-648): 0: 652: 100.00		CDN2B_HUMAN (3-136): 4.71e-52: 163: 81.34
+	Hs
		374070 RAF1_HUMAN (1-648): 0: 652: 100.00		ANK2_HUMAN (3-155): 1.76e-37: 137: 17.37
+	Hs
		374141 RAF1_HUMAN (1-648): 0: 652: 100.00		ANK3_HUMAN (15-155): 1.26e-35: 132: 21.13
+	Hs
		373957 RAF1_HUMAN (1-648): 0: 652: 100.00		RIPK4_HUMAN (9-155): 1.21e-30: 117: 25.68
+	Hs
		374864 RAF1_HUMAN (1-648): 0: 652: 100.00		Q9H4D1_HUMAN (9-155): 2.04e-30: 116: 25.68
+	Hs
		373840 RAF1_HUMAN (1-648): 0: 652: 100.00		CDN2C_HUMAN (21-135): 1.37e-25: 97.4: 28.21
+	Hs
		257542 RAF1_HUMAN (1-648): 0: 652: 100.00		ANR17_HUMAN (69-147): 2.99e-19: 85.1: 20.25
+	Hs
		373573 RAF1_HUMAN (1-648): 0: 652: 100.00		POTEJ_HUMAN (49-152): 1.44e-18: 83.1: 13.89
+	Hs
		374507 RAF1_HUMAN (1-648): 0: 652: 100.00		ANKH1_HUMAN (68-155): 3.32e-18: 82.3: 19.32
+	Hs
		375006 RAF1_HUMAN (1-648): 0: 652: 100.00		RAI14_HUMAN (1-64): 1.97e-11: 62.7: 21.21
+	Hs
		488608 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		CDN2B_HUMAN (3-136): 4.71e-52: 163: 81.34
+	Hs
		488633 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		RIPK4_HUMAN (9-155): 1.21e-30: 117: 25.68
+	Hs
		488803 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		Q9H4D1_HUMAN (9-155): 2.04e-30: 116: 25.68
+	Mm
		93731 BRAF_MOUSE (38-647): 3.22e-169: 503: 55.52		E9Q9B7_MOUSE (86-156): 1.54e-12: 65.8: 19.48
+	Hs
		883556 KSR1_HUMAN (138-648): 6.15e-108: 348: 24.61		RIPK4_HUMAN (9-155): 1.21e-30: 117: 25.68
+	Hs
		1217986 KSR1_HUMAN (138-648): 6.15e-108: 348: 24.61		Q9H4D1_HUMAN (9-155): 2.04e-30: 116: 25.68
+	Hs
		1217988 KSR1_HUMAN (138-648): 6.15e-108: 348: 24.61		TANC2_HUMAN (1-99): 3.54e-10: 59.3: 21.57