Protein: PSN1
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]

Gene: PSN1, PSEN1
Organism: Homo sapiens
Interactions: 244
UniProt ID: P49768

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000139 - Golgi membrane
GO:0000776 - kinetochore
GO:0001568 - blood vessel development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

890062

PEN2
Gamma-secretase subunit PEN-2

10

7

Small-scale

0.971

High

421726

A4
Amyloid-beta precursor protein

7

2

Small-scale

0.967

High

890031

APH1A
Gamma-secretase subunit APH-1A

7

10

Small-scale

0.961

High

889942

PSN1
Presenilin-1

6

7

Small-scale

0.942

High

889943

PSN2
Presenilin-2

3

7

Small-scale

0.850

High

890024

NICA
Nicastrin

12

6

Small-scale

0.755

High

764544

CTNB1
Catenin beta-1

6

2

Small-scale

0.732

High

555958

CADH1
Cadherin-1

5

5

Small-scale

0.712

High

890080

TRAF6
TNF receptor-associated factor 6

4

1

Small-scale

0.683

High

889944

GSK3B
Glycogen synthase kinase-3 beta

4

1

Small-scale

0.680

High

890075

UBQL1
Ubiquilin-1

3

3

Small-scale

0.667

High

889950

CADH8
Cadherin-8

3

5

High-throughput

0.662

High

633631

PSB1
Proteasome subunit beta type-1

2

6

Small-scale

0.644

High

700582

PSA5
Proteasome subunit alpha type-5

2

3

Small-scale

0.644

High

890019

SPP2B
Signal peptide peptidase-like 2B

3

0

High-throughput

0.634

High

254085

CTND1
Catenin delta-1

2

5

Small-scale

0.631

High

889969

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

2

4

Small-scale

0.629

High

890021

HUMMR
Protein MGARP

2

1

High-throughput

0.621

High

522061

BCL2
Apoptosis regulator Bcl-2

2

4

Small-scale

0.620

High

888826

TMEDA
Transmembrane emp24 domain-containing protein 10

2

1

Small-scale

0.618

High

890023

APH1B
Gamma-secretase subunit APH-1B

1

10

Small-scale

0.618

High

321204

ERLN2
Erlin-2

2

1

Small-scale

0.611

High

351880

S1PR4
Sphingosine 1-phosphate receptor 4

2

2

High-throughput

0.601

High

890045

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

1

High-throughput

0.599

High

857378

NOTC1
Neurogenic locus notch homolog protein 1

2

11

Small-scale

0.595

High

890040

PKP4
Plakophilin-4

1

5

Small-scale

0.586

High

375294

RASK
GTPase KRas

2

3

High-throughput

0.584

High

890079

CSEN
Calsenilin

2

4

Small-scale

0.584

High

889996

SOAT
Sodium-dependent organic anion transporter

2

0

High-throughput

0.580

High

890029

GCDH
Glutaryl-CoA dehydrogenase, mitochondrial

1

1

High-throughput

0.576

High

278041

FLNB
Filamin-B

1

5

Small-scale

0.573

High

890074

ICAM5
Intercellular adhesion molecule 5

1

2

Small-scale

0.573

High

637402

FLNA
Filamin-A

2

5

Small-scale

0.565

High

889985

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

2

0

Small-scale

0.559

High

889983

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

1

Small-scale

0.552

High

630408

RAB3A
Ras-related protein Rab-3A

1

1

High-throughput

0.541

High

138019

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

1

High-throughput

0.536

High

165291

PSA7
Proteasome subunit alpha type-7

1

3

High-throughput

0.536

High

191570

MAGB2
Melanoma-associated antigen B2

1

1

High-throughput

0.536

High

248574

FADS1
Acyl-CoA

1

1

High-throughput

0.536

High

258806

DNJA2
DnaJ homolog subfamily A member 2

1

3

High-throughput

0.536

High

350223

FADS2
Acyl-CoA 6-desaturase

1

1

High-throughput

0.536

High

534792

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.536

High

610267

PRS6A
26S proteasome regulatory subunit 6A

1

1

High-throughput

0.536

High

681126

PSA2
Proteasome subunit alpha type-2

1

4

High-throughput

0.536

High

681597

PSA4
Proteasome subunit alpha type-4

1

3

High-throughput

0.536

High

701116

PSB5
Proteasome subunit beta type-5

1

3

High-throughput

0.536

High

727727

DNJA1
DnaJ homolog subfamily A member 1

1

3

High-throughput

0.536

High

732959

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

1

High-throughput

0.536

High

827146

ARL1
ADP-ribosylation factor-like protein 1

1

1

High-throughput

0.536

High

844991

EAA3
Excitatory amino acid transporter 3

1

1

High-throughput

0.536

High

856589

BAG6
Large proline-rich protein BAG6

1

3

High-throughput

0.536

High

863438

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

1

High-throughput

0.536

High

878005

AGRE5
Adhesion G protein-coupled receptor E5

1

1

High-throughput

0.536

High

887622

PSB2
Proteasome subunit beta type-2

1

4

High-throughput

0.536

High

889951

CAD12
Cadherin-12

1

5

High-throughput

0.536

High

889956

PSA6
Proteasome subunit alpha type-6

1

4

High-throughput

0.536

High

889958

TSN5
Tetraspanin-5

1

1

High-throughput

0.536

High

889970

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

2

High-throughput

0.536

High

889989

AAAT
Neutral amino acid transporter B(0)

1

1

High-throughput

0.536

High

889992

CP51A
Lanosterol 14-alpha demethylase

1

2

High-throughput

0.536

High

890032

FAF2
FAS-associated factor 2

1

1

High-throughput

0.536

High

890039

DNJC2
DnaJ homolog subfamily C member 2

1

3

High-throughput

0.536

High

890041

DNJC7
DnaJ homolog subfamily C member 7

1

2

High-throughput

0.536

High

890046

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.536

High

890058

SAR1A
Small COPII coat GTPase SAR1A

1

1

High-throughput

0.536

High

890068

DJB11
DnaJ homolog subfamily B member 11

1

3

High-throughput

0.536

High

890081

SRPRB
Signal recognition particle receptor subunit beta

1

2

High-throughput

0.536

High

889945

F10A1
Hsc70-interacting protein

1

2

High-throughput

0.531

High

889963

SKP1
S-phase kinase-associated protein 1

1

0

High-throughput

0.530

High

889988

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.530

High

890063

TREM2
Triggering receptor expressed on myeloid cells 2

1

0

Small-scale

0.530

High

889953

BACE1
Beta-secretase 1

1

0

Small-scale

0.519

High

339142

TYDP2
Tyrosyl-DNA phosphodiesterase 2

1

0

High-throughput

0.518

High

387389

APOE
Apolipoprotein E

1

0

High-throughput

0.518

High

889967

CDK5
Cyclin-dependent kinase 5

1

0

High-throughput

0.518

High

890000

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

0

High-throughput

0.518

High

890036

PRAM
PML-RARA-regulated adapter molecule 1

1

0

High-throughput

0.518

High

210178

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

1

Small-scale

0.515

High

62327

A4FUJ8
MKL1 protein

1

1

High-throughput

0.515

High

131217

TR11B
Tumor necrosis factor receptor superfamily member 11B

1

1

High-throughput

0.515

High

391206

FRIL
Ferritin light chain

1

1

High-throughput

0.515

High

889948

PLK1
Serine/threonine-protein kinase PLK1

1

1

High-throughput

0.515

High

889961

AP2B1
AP-2 complex subunit beta

1

1

High-throughput

0.515

High

889965

H31
Histone H3.1

1

1

High-throughput

0.515

High

889995

SGSM1
Small G protein signaling modulator 1

1

1

High-throughput

0.515

High

890007

RN111
E3 ubiquitin-protein ligase Arkadia

1

1

High-throughput

0.515

High

890014

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.515

High

890035

ZMAT2
Zinc finger matrin-type protein 2

1

1

High-throughput

0.515

High

890051

SKI8
Superkiller complex protein 8

1

4

High-throughput

0.515

High

890083

MOFA1
MORF4 family-associated protein 1

1

1

High-throughput

0.515

High

130039

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.513

High

144416

SCD
Stearoyl-CoA desaturase

1

0

High-throughput

0.513

High

167500

TX1B3
Tax1-binding protein 3

1

0

High-throughput

0.513

High

178620

DEGS1
Sphingolipid delta(4)-desaturase DES1

1

0

High-throughput

0.513

High

211755

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.513

High

215515

EMC8
ER membrane protein complex subunit 8

1

0

High-throughput

0.513

High

226315

SNG1
Synaptogyrin-1

1

0

High-throughput

0.513

High

260847

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.513

High

346906

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

415431

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.513

High

418014

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.513

High

536755

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.513

High

598035

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

0

High-throughput

0.513

High

612167

ARF4
ADP-ribosylation factor 4

1

0

High-throughput

0.513

High

773825

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.513

High

778633

PRS7
26S proteasome regulatory subunit 7

1

0

High-throughput

0.513

High

813033

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.513

High

842689

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

0

High-throughput

0.513

High

847470

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.513

High

854606

RAGP1
Ran GTPase-activating protein 1

1

0

High-throughput

0.513

High

889946

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.513

High

889947

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.513

High

889954

TMM33
Transmembrane protein 33

1

0

High-throughput

0.513

High

889955

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.513

High

889968

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.513

High

889973

SIA4A
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

1

0

High-throughput

0.513

High

889974

TBL3
Transducin beta-like protein 3

1

0

High-throughput

0.513

High

889976

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

0

High-throughput

0.513

High

889978

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

High-throughput

0.513

High

889981

MLEC
Malectin

1

0

High-throughput

0.513

High

889984

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.513

High

889986

PCBP2
Poly(rC)-binding protein 2

1

0

High-throughput

0.513

High

889993

DOXA2
Dual oxidase maturation factor 2

1

0

High-throughput

0.513

High

889998

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

0

High-throughput

0.513

High

890004

RHBD2
Rhomboid domain-containing protein 2

1

0

High-throughput

0.513

High

890009

TM11B
Transmembrane protease serine 11B

1

0

High-throughput

0.513

High

890011

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

0

High-throughput

0.513

High

890013

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.513

High

890015

SERP2
Stress-associated endoplasmic reticulum protein 2

1

0

High-throughput

0.513

High

890016

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.513

High

890018

RDH11
Retinol dehydrogenase 11

1

0

High-throughput

0.513

High

890028

PTPR2
Receptor-type tyrosine-protein phosphatase N2

1

0

High-throughput

0.513

High

890047

TMM43
Transmembrane protein 43

1

0

High-throughput

0.513

High

890054

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

890056

CHM1A
Charged multivesicular body protein 1a

1

0

High-throughput

0.513

High

890067

HACD3
Very-long-chain

1

0

High-throughput

0.513

High

890069

DDX20
Probable ATP-dependent RNA helicase DDX20

1

0

High-throughput

0.513

High

890071

CNOT7
CCR4-NOT transcription complex subunit 7

1

0

High-throughput

0.513

High

890073

TMCO1
Calcium load-activated calcium channel

1

0

High-throughput

0.513

High

890076

SSRG
Translocon-associated protein subunit gamma

1

0

High-throughput

0.513

High

890082

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.513

High

889972

B2CL1
Bcl-2-like protein 1

1

4

Small-scale

0.508

High

890077

CTND2
Catenin delta-2

1

5

Small-scale

0.506

High

577669

PLAK
Junction plakoglobin

1

3

Small-scale

0.501

High

890026

RYR2
Ryanodine receptor 2

1

1

Small-scale

0.501

High

890042

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

1

4

Small-scale

0.501

High

889980

DSG2
Desmoglein-2

1

6

Small-scale

0.500

High

890017

DNER
Delta and Notch-like epidermal growth factor-related receptor

1

11

Small-scale

0.500

High

774207

BASI
Basigin

1

0

Small-scale

0.494

High

154528

PLPP1
Phospholipid phosphatase 1

1

0

High-throughput

0.493

High

599105

CBPE
Carboxypeptidase E

1

0

High-throughput

0.493

High

889971

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.493

High

889975

HYAL2
Hyaluronidase-2

1

0

High-throughput

0.493

High

890001

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

0

High-throughput

0.493

High

890034

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.493

High

890044

SPAG8
Sperm-associated antigen 8

1

0

High-throughput

0.493

High

890050

LDH6B
L-lactate dehydrogenase A-like 6B

1

0

High-throughput

0.493

High

890055

DCR1B
5' exonuclease Apollo

1

0

High-throughput

0.493

High

890072

RN112
RING finger protein 112

1

0

High-throughput

0.493

High

226964

ENSA
Alpha-endosulfine

1

0

High-throughput

0.486

High

408736

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.486

High

539046

UMPS
Uridine 5'-monophosphate synthase

1

0

High-throughput

0.486

High

555637

ACTN1
Alpha-actinin-1

1

0

High-throughput

0.486

High

659999

COF1
Cofilin-1

1

0

High-throughput

0.486

High

889952

SCOT1
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial

1

0

High-throughput

0.486

High

890038

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.486

High

890048

EFHD1
EF-hand domain-containing protein D1

1

0

High-throughput

0.486

High

890078

E41L3
Band 4.1-like protein 3

1

0

High-throughput

0.486

High

693605

RL10
Large ribosomal subunit protein uL16

1

0

Small-scale

0.484

High

570379

GFAP
Glial fibrillary acidic protein

1

1

Small-scale

0.481

High

481161

HMGB1
High mobility group protein B1

1

1

High-throughput

0.481

High

528915

CP2C8
Cytochrome P450 2C8

1

1

High-throughput

0.481

High

713073

NOS3
Nitric oxide synthase 3

1

1

High-throughput

0.481

High

750558

CP2CI
Cytochrome P450 2C18

1

1

High-throughput

0.481

High

889949

RD23A
UV excision repair protein RAD23 homolog A

1

3

High-throughput

0.481

High

889987

RHEB
GTP-binding protein Rheb

1

2

High-throughput

0.481

High

889997

PDCD4
Programmed cell death protein 4

1

2

High-throughput

0.481

High

890005

KCIP4
Kv channel-interacting protein 4

1

4

Small-scale

0.481

High

890043

CIB1
Calcium and integrin-binding protein 1

1

4

Small-scale

0.481

High

890052

RNF32
RING finger protein 32

1

1

High-throughput

0.481

High

853768

MK09
Mitogen-activated protein kinase 9

1

0

Small-scale

0.480

High

591199

ANPRA
Atrial natriuretic peptide receptor 1

1

0

Small-scale

0.479

High

889979

DAG1
Dystroglycan 1

1

0

Small-scale

0.479

High

890002

VASN
Vasorin

1

0

Small-scale

0.479

High

890006

PXDC2
Plexin domain-containing protein 2

1

0

Small-scale

0.479

High

323975

CSTN1
Calsyntenin-1

1

3

Small-scale

0.479

High

373838

RASN
GTPase NRas

1

3

High-throughput

0.479

High

374469

RASH
GTPase HRas

1

3

High-throughput

0.479

High

618229

CADH2
Cadherin-2

1

6

Small-scale

0.479

High

889960

GRB2
Growth factor receptor-bound protein 2

1

1

Small-scale

0.479

High

889990

VAMP3
Vesicle-associated membrane protein 3

1

1

High-throughput

0.479

High

889994

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

890030

FBXW7
F-box/WD repeat-containing protein 7

1

1

Small-scale

0.479

High

890057

TF7L2
Transcription factor 7-like 2

1

1

Small-scale

0.479

High

890061

DJB12
DnaJ homolog subfamily B member 12

1

2

High-throughput

0.479

High

889977

PDZ1I
PDZK1-interacting protein 1

1

1

High-throughput

0.470

High

417321

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.464

High

568383

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

Small-scale

0.460

High

732266

PRDX2
Peroxiredoxin-2

1

0

High-throughput

0.460

High

771745

SCN1A
Sodium channel protein type 1 subunit alpha

1

0

High-throughput

0.460

High

890027

FGF13
Fibroblast growth factor 13

1

0

High-throughput

0.460

High

890033

STALP
AMSH-like protease

1

0

High-throughput

0.460

High

890037

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

0

Small-scale

0.460

High

890066

ITSN2
Intersectin-2

1

0

High-throughput

0.460

High

890084

AP1M2
AP-1 complex subunit mu-2

1

0

High-throughput

0.460

High

282569

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

0

Small-scale

0.458

High

507685

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.458

High

593647

BGAL
Beta-galactosidase

1

0

High-throughput

0.458

High

764281

CTNA1
Catenin alpha-1

1

0

Small-scale

0.458

High

771058

PE2R4
Prostaglandin E2 receptor EP4 subtype

1

0

Small-scale

0.458

High

787363

TGFR1
TGF-beta receptor type-1

1

0

Small-scale

0.458

High

890003

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

890053

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

890065

MTCH1
Mitochondrial carrier homolog 1

1

0

Small-scale

0.458

High

848460

MAGA8
Melanoma-associated antigen 8

1

1

High-throughput

0.445

High

867604

GPR12
G-protein coupled receptor 12

1

2

High-throughput

0.445

High

889966

DLK1
Protein delta homolog 1

1

12

High-throughput

0.445

High

890020

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

1

1

High-throughput

0.445

High

890025

LPAR1
Lysophosphatidic acid receptor 1

1

2

High-throughput

0.445

High

890060

FXL12
F-box/LRR-repeat protein 12

1

1

High-throughput

0.439

High

216644

HTRA2
Serine protease HTRA2, mitochondrial

1

0

Small-scale

0.438

High

889959

RB11A
Ras-related protein Rab-11A

1

0

Small-scale

0.438

High

61866

GSAP
Gamma-secretase-activating protein

1

1

Small-scale

0.437

High

538831

GTR3
Solute carrier family 2, facilitated glucose transporter member 3

1

0

Small-scale

0.426

High

563426

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

607291

NEUM
Neuromodulin

1

0

Small-scale

0.426

High

880818

NRAM2
Natural resistance-associated macrophage protein 2

1

0

High-throughput

0.426

High

886039

CXCR3
C-X-C chemokine receptor type 3

1

0

High-throughput

0.426

High

889957

STXB1
Syntaxin-binding protein 1

1

0

Small-scale

0.426

High

889982

FLOT2
Flotillin-2

1

0

Small-scale

0.426

High

890010

OSTB
Organic solute transporter subunit beta

1

0

High-throughput

0.426

High

890022

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

0

High-throughput

0.426

High

890064

GPC5B
G-protein coupled receptor family C group 5 member B

1

0

High-throughput

0.426

High

889991

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.308

High

889962

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.279

Low

889999

DALD3
DALR anticodon-binding domain-containing protein 3

1

0

High-throughput

0.268

Low

890012

OOSP2
Oocyte-secreted protein 2

1

0

High-throughput

0.268

Low

890049

KRA92
Keratin-associated protein 9-2

1

0

High-throughput

0.268

Low

890059

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.268

Low

890070

FEZ2
Fasciculation and elongation protein zeta-2

1

0

High-throughput

0.268

Low

889964

TBA1B
Tubulin alpha-1B chain

1

0

High-throughput

0.251

Low

890008

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025