HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: TCPG (P49368)
T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) (Chaperonin containing T-complex polypeptide 1 subunit 3) (hTRiC5)
Gene: CCT3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.677

Property	Details
Experiments	12620389, 31980649, unassigned2173, 37045861
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 545
+	Hs
		374759 RAF1_HUMAN (1-648): 0: 652: 100.00		TCPH_HUMAN (2-536): 0: 574: 31.18
+	Hs
		373868 RAF1_HUMAN (1-648): 0: 652: 100.00		TCPE_HUMAN (4-530): 0: 559: 32.52
+	Hs
		373647 RAF1_HUMAN (1-648): 0: 652: 100.00		TCPA_HUMAN (10-533): 0: 549: 33.09
+	Hs
		488618 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		TCPG_HUMAN (1-545): 0: 640: 100.00
+	Hs
		542913 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		TCPH_HUMAN (2-536): 0: 574: 31.18
+	Hs
		488790 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		TCPH_HUMAN (2-536): 0: 574: 31.18
+	Hs
		488566 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		TCPA_HUMAN (10-533): 0: 549: 33.09
+	Hs
		433290 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		TCPG_HUMAN (1-545): 0: 640: 100.00
+	Hs
		412086 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		TCPG_HUMAN (1-545): 0: 640: 100.00
+	Hs
		373897 RAF1_HUMAN (1-648): 0: 652: 100.00		TCPD_HUMAN (16-524): 1.08e-90: 290: 34.56
+	Hs
		412325 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		TCPH_HUMAN (2-536): 0: 574: 31.18
+	Hs
		412084 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		TCPE_HUMAN (4-530): 0: 559: 32.52
+	Hs
		433248 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		TCPA_HUMAN (10-533): 0: 549: 33.09
+	Hs
		411996 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		TCPA_HUMAN (10-533): 0: 549: 33.09
+	Hs
		488624 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		TCPD_HUMAN (16-524): 1.08e-90: 290: 34.56
+	Hs
		412093 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		TCPD_HUMAN (16-524): 1.08e-90: 290: 34.56