HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	36244648, 37045861
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EF-hand_7~Pkinase
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 2472
+	Hs
		164550 RAF1_HUMAN (1-648): 0: 652: 100.00		SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41
+	Hs
		374065 RAF1_HUMAN (1-648): 0: 652: 100.00		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		374260 RAF1_HUMAN (1-648): 0: 652: 100.00		PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18
+	Hs
		542915 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		SPTN4_HUMAN (961-2371): 1.09e-21: 105: 13.80
+	Hs
		521454 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25
+	Hs
		211480 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15