HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: H90B2 (Q58FF8)
Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb)
Gene: HSP90AB2P

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned2173
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 648 Hs			1 381
+	Hs
		374338 RAF1_HUMAN (1-648): 0: 652: 100.00		H90B3_HUMAN (1-381): 8.64e-116: 350: 59.04
+	Hs
		373626 RAF1_HUMAN (1-648): 0: 652: 100.00		ENPL_HUMAN (185-381): 1.31e-65: 224: 34.98
+	Hs
		542890 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		H90B3_HUMAN (1-381): 8.64e-116: 350: 59.04
+	Hs
		488742 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		H90B3_HUMAN (1-381): 8.64e-116: 350: 59.04
+	Hs
		374140 RAF1_HUMAN (1-648): 0: 652: 100.00		TRAP1_HUMAN (135-380): 3.01e-42: 158: 20.45
+	Hs
		374409 RAF1_HUMAN (1-648): 0: 652: 100.00		Q6PK50_HUMAN (109-251): 1.1e-33: 130: 87.41
+	Hs
		373549 RAF1_HUMAN (1-648): 0: 652: 100.00		HS90B_HUMAN (109-251): 8.66e-32: 128: 87.41
+	Hs
		373543 RAF1_HUMAN (1-648): 0: 652: 100.00		HS90A_HUMAN (87-251): 2.97e-26: 112: 61.54
+	Hs
		538082 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		ENPL_HUMAN (185-381): 1.31e-65: 224: 34.98
+	Hs
		488555 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		ENPL_HUMAN (185-381): 1.31e-65: 224: 34.98
+	Hs
		542869 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		TRAP1_HUMAN (135-380): 3.01e-42: 158: 20.45
+	Hs
		437860 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		HS90B_HUMAN (109-251): 8.66e-32: 128: 87.41
+	Hs
		437832 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		HS90B_HUMAN (109-251): 8.66e-32: 128: 87.41
+	Hs
		1162518 Q96II5_HUMAN (45-646): 9.01e-168: 494: 58.82		Q6PK50_HUMAN (109-251): 1.1e-33: 130: 87.41
+	Hs
		431496 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		HS90A_HUMAN (87-251): 2.97e-26: 112: 61.54
+	Gg
		513713 BRAF_CHICK (38-647): 1.98e-169: 504: 56.96		HS90A_CHICK (109-251): 7.49e-27: 114: 69.23
+	Mm
		432406 BRAF_MOUSE (38-647): 3.22e-169: 503: 55.52		HS90A_MOUSE (87-251): 1.56e-26: 113: 59.41
+	Hs
		431459 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		HS90A_HUMAN (87-251): 2.97e-26: 112: 61.54
+	Hs
		432156 Q96II5_HUMAN (45-646): 9.01e-168: 494: 58.82		HS90A_HUMAN (87-251): 2.97e-26: 112: 61.54
+	Mm
		435915 BRAF_MOUSE (38-647): 3.22e-169: 503: 55.52		ENPL_MOUSE (13-132): 2.57e-22: 100: 51.24