Protein: ECHM
Enoyl-CoA hydratase, mitochondrial (mECH) (mECH1) (EC 4.2.1.17) (EC 5.3.3.8) (Enoyl-CoA hydratase 1) (ECHS1) (Short-chain enoyl-CoA hydratase) (SCEH)

Gene: ECHM, ECHS1
Organism: Homo sapiens
Interactions: 192
UniProt ID: P30084

Gene Ontology (top 5):
GO:0004165 - delta(3)-delta(2)-enoyl-CoA isomerase activity
GO:0004300 - enoyl-CoA hydratase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006635 - fatty acid beta-oxidation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

505937

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

3

6

High-throughput

0.667

High

671462

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

3

6

Small-scale

0.656

High

671478

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

3

0

High-throughput

0.638

High

671402

ECHM
Enoyl-CoA hydratase, mitochondrial

1

14

High-throughput

0.621

High

671445

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

15

High-throughput

0.618

High

671403

LONM
Lon protease homolog, mitochondrial

2

4

High-throughput

0.611

High

671456

HERC1
Probable E3 ubiquitin-protein ligase HERC1

3

11

High-throughput

0.609

High

671459

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

2

5

High-throughput

0.602

High

262723

CISY
Citrate synthase, mitochondrial

2

5

High-throughput

0.584

High

373748

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

4

High-throughput

0.584

High

525428

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

2

2

High-throughput

0.584

High

671439

GRSF1
G-rich sequence factor 1

2

4

High-throughput

0.584

High

671440

TRAP1
Heat shock protein 75 kDa, mitochondrial

2

6

High-throughput

0.584

High

671458

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

5

High-throughput

0.584

High

671548

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

3

Small-scale

0.584

High

671530

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

5

Small-scale

0.561

High

671444

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

2

3

High-throughput

0.558

High

671449

CUL7
Cullin-7

2

5

High-throughput

0.558

High

452641

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

607005

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

0

High-throughput

0.518

High

671485

KAT2A
Histone acetyltransferase KAT2A

1

6

Small-scale

0.512

High

398439

CP2E1
Cytochrome P450 2E1

1

1

High-throughput

0.494

High

671417

FXR1
RNA-binding protein FXR1

1

5

High-throughput

0.494

High

671418

FXR2
RNA-binding protein FXR2

1

5

High-throughput

0.494

High

201233

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

2

High-throughput

0.489

High

317411

YETS4
YEATS domain-containing protein 4

1

1

High-throughput

0.489

High

671434

KPCZ
Protein kinase C zeta type

1

6

High-throughput

0.489

High

671475

CUL9
Cullin-9

1

5

High-throughput

0.489

High

671481

NEDD1
Protein NEDD1

1

3

High-throughput

0.489

High

671508

DDA1
DET1- and DDB1-associated protein 1

1

1

High-throughput

0.489

High

427848

CAN1
Calpain-1 catalytic subunit

1

1

Small-scale

0.481

High

59119

VWA8
von Willebrand factor A domain-containing protein 8

1

2

High-throughput

0.479

High

63294

MET15
12S rRNA N4-methylcytidine

1

2

High-throughput

0.479

High

226616

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

264849

MPPB
Mitochondrial-processing peptidase subunit beta

1

7

High-throughput

0.479

High

269986

RF1M
Peptide chain release factor 1, mitochondrial

1

5

High-throughput

0.479

High

327367

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

3

High-throughput

0.479

High

440359

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

6

High-throughput

0.479

High

455127

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.479

High

486466

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

4

High-throughput

0.479

High

499556

CH60
60 kDa heat shock protein, mitochondrial

1

5

High-throughput

0.479

High

671407

MDHM
Malate dehydrogenase, mitochondrial

1

5

High-throughput

0.479

High

671408

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

2

High-throughput

0.479

High

671409

EFTS
Elongation factor Ts, mitochondrial

1

5

High-throughput

0.479

High

671411

IF2M
Translation initiation factor IF-2, mitochondrial

1

7

High-throughput

0.479

High

671415

EFTU
Elongation factor Tu, mitochondrial

1

2

High-throughput

0.479

High

671430

TFAM
Transcription factor A, mitochondrial

1

7

High-throughput

0.479

High

671433

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

671435

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

4

High-throughput

0.479

High

671438

MPPA
Mitochondrial-processing peptidase subunit alpha

1

7

High-throughput

0.479

High

671448

ICT1
Large ribosomal subunit protein mL62

1

3

High-throughput

0.479

High

671453

PDK1
[Pyruvate dehydrogenase

1

6

High-throughput

0.479

High

671461

SYAM
Alanine--tRNA ligase, mitochondrial

1

4

High-throughput

0.479

High

671464

MRM1
rRNA methyltransferase 1, mitochondrial

1

4

High-throughput

0.479

High

671465

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

1

High-throughput

0.479

High

671472

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

9

High-throughput

0.479

High

671474

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

4

High-throughput

0.479

High

671487

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

7

High-throughput

0.479

High

671488

FAKD4
FAST kinase domain-containing protein 4

1

9

High-throughput

0.479

High

671489

MCUR1
Mitochondrial calcium uniporter regulator 1

1

3

High-throughput

0.479

High

671492

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

671493

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

3

High-throughput

0.479

High

671494

RRFM
Ribosome-recycling factor, mitochondrial

1

3

High-throughput

0.479

High

671495

MTEF3
Transcription termination factor 3, mitochondrial

1

2

High-throughput

0.479

High

671496

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

1

High-throughput

0.479

High

671497

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

671498

TEFM
Transcription elongation factor, mitochondrial

1

1

High-throughput

0.479

High

671499

EFGM
Elongation factor G, mitochondrial

1

8

High-throughput

0.479

High

671503

TACO1
Translational activator of cytochrome c oxidase 1

1

1

High-throughput

0.479

High

671505

MTG1
Mitochondrial ribosome-associated GTPase 1

1

1

High-throughput

0.479

High

671507

TR61B
tRNA

1

3

High-throughput

0.479

High

671509

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

2

High-throughput

0.479

High

671511

RT26
Small ribosomal subunit protein mS26

1

2

High-throughput

0.479

High

671513

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

5

High-throughput

0.479

High

671514

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

3

High-throughput

0.479

High

671516

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

2

High-throughput

0.479

High

671518

IF3M
Translation initiation factor IF-3, mitochondrial

1

1

High-throughput

0.479

High

671520

MTRFR
Mitochondrial translation release factor in rescue

1

5

High-throughput

0.479

High

671522

MTG2
Mitochondrial ribosome-associated GTPase 2

1

4

High-throughput

0.479

High

671524

MET17
Ribosome assembly protein METTL17, mitochondrial

1

2

High-throughput

0.479

High

671525

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

8

High-throughput

0.479

High

671527

NGRN
Neugrin

1

1

High-throughput

0.479

High

671531

DDX28
Probable ATP-dependent RNA helicase DDX28

1

2

High-throughput

0.479

High

671532

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

1

High-throughput

0.479

High

671533

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

1

High-throughput

0.479

High

671534

RMND1
Required for meiotic nuclear division protein 1 homolog

1

1

High-throughput

0.479

High

671535

AKIP
Small ribosomal subunit protein mS38

1

2

High-throughput

0.479

High

671537

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

9

High-throughput

0.479

High

671538

MRES1
Mitochondrial transcription rescue factor 1

1

3

High-throughput

0.479

High

671541

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

5

High-throughput

0.479

High

671546

RM11
Large ribosomal subunit protein uL11m

1

2

High-throughput

0.479

High

505562

EPB41
Protein 4.1

1

3

High-throughput

0.470

High

671427

GRB2
Growth factor receptor-bound protein 2

1

4

High-throughput

0.464

High

671406

STAT3
Signal transducer and activator of transcription 3

1

2

Small-scale

0.462

High

336843

OTC
Ornithine transcarbamylase, mitochondrial

1

0

High-throughput

0.458

High

671405

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

671455

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

671471

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

671490

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

671491

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

671506

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

671519

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

671423

CDC42
Cell division control protein 42 homolog

1

3

High-throughput

0.457

High

671432

ERCC6
DNA excision repair protein ERCC-6

1

4

High-throughput

0.457

High

496388

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.445

High

671451

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

9

Small-scale

0.445

High

671552

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

5

High-throughput

0.445

High

344166

A1AT
Alpha-1-antitrypsin

1

1

High-throughput

0.439

High

172980

RT12
Small ribosomal subunit protein uS12m

1

1

High-throughput

0.437

High

196267

PJA2
E3 ubiquitin-protein ligase Praja-2

1

1

Small-scale

0.437

High

201762

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

5

High-throughput

0.437

High

329408

AGR2
Anterior gradient protein 2 homolog

1

3

High-throughput

0.437

High

354315

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

2

High-throughput

0.437

High

384338

NTRK1
High affinity nerve growth factor receptor

1

13

High-throughput

0.437

High

503508

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.437

High

554804

TIMP2
Metalloproteinase inhibitor 2

1

1

High-throughput

0.437

High

617442

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.437

High

671410

RECQ1
ATP-dependent DNA helicase Q1

1

2

High-throughput

0.437

High

671413

PRC2A
Protein PRRC2A

1

4

Small-scale

0.437

High

671414

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.437

High

671416

CDK7
Cyclin-dependent kinase 7

1

5

High-throughput

0.437

High

671420

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

3

Small-scale

0.437

High

671422

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

7

High-throughput

0.437

High

671425

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.437

High

671428

1433Z
14-3-3 protein zeta/delta

1

1

High-throughput

0.437

High

671429

RHOG
Rho-related GTP-binding protein RhoG

1

3

High-throughput

0.437

High

671431

KIF23
Kinesin-like protein KIF23

1

4

High-throughput

0.437

High

671436

KLC1
Kinesin light chain 1

1

1

High-throughput

0.437

High

671437

QOR
Quinone oxidoreductase

1

2

High-throughput

0.437

High

671441

PAK2
Serine/threonine-protein kinase PAK 2

1

1

High-throughput

0.437

High

671442

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.437

High

671443

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

3

High-throughput

0.437

High

671447

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

2

High-throughput

0.437

High

671452

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.437

High

671457

EZH2
Histone-lysine N-methyltransferase EZH2

1

7

High-throughput

0.437

High

671460

DCAF6
DDB1- and CUL4-associated factor 6

1

4

High-throughput

0.437

High

671463

ECM29
Proteasome adapter and scaffold protein ECM29

1

2

Small-scale

0.437

High

671467

BRWD3
Bromodomain and WD repeat-containing protein 3

1

7

Small-scale

0.437

High

671468

WDR87
WD repeat-containing protein 87

1

2

Small-scale

0.437

High

671469

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.437

High

671470

SND1
Staphylococcal nuclease domain-containing protein 1

1

2

High-throughput

0.437

High

671476

CC146
Coiled-coil domain-containing protein 146

1

5

Small-scale

0.437

High

671480

TNIP2
TNFAIP3-interacting protein 2

1

2

High-throughput

0.437

High

671483

SH3R2
E3 ubiquitin-protein ligase SH3RF2

1

2

Small-scale

0.437

High

671484

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.437

High

671500

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.437

High

671502

BAG1
BAG family molecular chaperone regulator 1

1

1

High-throughput

0.437

High

671504

CQ080
Mitochondrial nucleoid-associated protein 1

1

2

High-throughput

0.437

High

671515

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

1

High-throughput

0.437

High

671523

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

671528

ANLN
Anillin

1

3

High-throughput

0.437

High

671529

BRWD1
Bromodomain and WD repeat-containing protein 1

1

6

Small-scale

0.437

High

671540

EPHA6
Ephrin type-A receptor 6

1

10

High-throughput

0.437

High

671542

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.437

High

671543

BAZ2B
Bromodomain adjacent to zinc finger domain protein 2B

1

3

Small-scale

0.437

High

671544

TNIK
TRAF2 and NCK-interacting protein kinase

1

3

High-throughput

0.437

High

671545

PA2G4
Proliferation-associated protein 2G4

1

1

High-throughput

0.437

High

671547

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

1

High-throughput

0.437

High

671549

TRAF6
TNF receptor-associated factor 6

1

12

High-throughput

0.437

High

671550

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

2

Small-scale

0.437

High

671551

DJC15
DnaJ homolog subfamily C member 15

1

3

High-throughput

0.437

High

671454

TLR1
Toll-like receptor 1

1

1

Small-scale

0.417

High

671486

TRI63
E3 ubiquitin-protein ligase TRIM63

1

13

High-throughput

0.417

High

671510

TLR10
Toll-like receptor 10

1

1

Small-scale

0.417

High

671521

SAV1
Protein salvador homolog 1

1

6

Small-scale

0.417

High

671526

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

6

High-throughput

0.417

High

528618

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.407

High

671446

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

3

High-throughput

0.407

High

671512

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.407

High

273374

PPM1B
Protein phosphatase 1B

1

0

High-throughput

0.282

High

671421

CLD12
Claudin-12

1

0

High-throughput

0.282

High

671473

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

1

0

High-throughput

0.282

High

235724

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.279

Low

671404

PSB10
Proteasome subunit beta type-10

1

0

High-throughput

0.279

Low

671412

BAG6
Large proline-rich protein BAG6

1

0

High-throughput

0.279

Low

671426

YPEL5
Protein yippee-like 5

1

0

High-throughput

0.279

Low

671482

PHOP1
Phosphoethanolamine/phosphocholine phosphatase

1

0

High-throughput

0.279

Low

671419

ZN157
Zinc finger protein 157

1

0

High-throughput

0.269

Low

671450

SLMAP
Sarcolemmal membrane-associated protein

1

0

High-throughput

0.269

Low

198555

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

0

Small-scale

0.249

Low

239507

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.249

Low

351724

SOMA
Somatotropin

1

0

High-throughput

0.249

Low

585631

TFE3
Transcription factor E3

1

0

High-throughput

0.249

Low

671424

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

High-throughput

0.249

Low

671466

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.249

Low

671477

RBIS
Ribosomal biogenesis factor

1

0

High-throughput

0.249

Low

671479

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

671501

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

0

Small-scale

0.249

Low

671517

ATG5
Autophagy protein 5

1

0

High-throughput

0.249

Low

671536

DJC28
DnaJ homolog subfamily C member 28

1

0

High-throughput

0.249

Low

671539

TRM7
tRNA

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024