HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: Q9BPW0 (Q9BPW0)
Serine/threonine-protein phosphatase (EC 3.1.3.16)
Gene: PPP5C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0046872 - metal ion binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 484
+	Hs
		374028 RAF1_HUMAN (1-648): 0: 652: 100.00		PP2AA_HUMAN (188-483): 3.01e-169: 480: 40.33
+	Hs
		374005 RAF1_HUMAN (1-648): 0: 652: 100.00		PP2AB_HUMAN (190-483): 3.71e-154: 442: 39.32
+	Hs
		373994 RAF1_HUMAN (1-648): 0: 652: 100.00		PP1B_HUMAN (194-482): 2.2e-153: 441: 36.90
+	Hs
		373800 RAF1_HUMAN (1-648): 0: 652: 100.00		PP1G_HUMAN (195-481): 2.06e-152: 438: 37.85
+	Hs
		1294466 Q96II5_HUMAN (45-646): 9.01e-168: 494: 58.82		Q9BPW0_HUMAN (1-484): 0: 546: 100.00
+	Hs
		542859 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		PP2AA_HUMAN (188-483): 3.01e-169: 480: 40.33
+	Hs
		542850 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		PP2AB_HUMAN (190-483): 3.71e-154: 442: 39.32
+	Hs
		542848 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		PP1A_HUMAN (196-479): 3.63e-152: 438: 38.25
+	Mm
		655939 BRAF_MOUSE (38-647): 3.22e-169: 503: 55.52		PP2AB_MOUSE (190-483): 3.71e-154: 442: 39.32
+	Mm
		655937 BRAF_MOUSE (38-647): 3.22e-169: 503: 55.52		PP1A_MOUSE (196-479): 1.86e-152: 438: 38.25
+	Gg
		819348 BRAF_CHICK (38-647): 1.98e-169: 504: 56.96		PP2AA_CHICK (191-483): 5.22e-148: 426: 39.12
+	Mm
		930631 KSR1_MOUSE (138-648): 3.37e-119: 377: 27.44		PP2AA_MOUSE (188-483): 3.95e-169: 480: 40.33
+	Hs
		915235 KSR1_HUMAN (138-648): 6.15e-108: 348: 24.61		PP2AB_HUMAN (190-483): 3.71e-154: 442: 39.32
+	Hs
		522884 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		PP2AB_HUMAN (190-483): 3.71e-154: 442: 39.32
+	Hs
		111444 J3QRU1_HUMAN (329-607): 1.4e-105: 332: 33.92		PP1B_HUMAN (194-482): 2.2e-153: 441: 36.90
+	Hs
		433310 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		PP1B_HUMAN (194-482): 2.2e-153: 441: 36.90
+	Hs
		1167083 KSR2_HUMAN (332-623): 6.72e-43: 168: 34.43		Q9BPW0_HUMAN (1-484): 0: 546: 100.00
+	Hs
		858637 KSR2_HUMAN (332-623): 6.72e-43: 168: 34.43		PPP5_HUMAN (1-482): 0: 546: 99.17