HitPredict

Interactor 1: GCR (P04150)
Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1)
Gene: NR3C1

Interactor 2: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	16131566, 15004035, 35124280
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 777 Hs			1 840
+	Rn
		291976 GCR_RAT (1-777): 0: 878: 88.22		HSP74_RAT (1-840): 0: 979: 95.83
+	Hs
		369085 ESR1_HUMAN (263-760): 1.11e-129: 400: 23.06		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		320786 ESR1_HUMAN (263-760): 1.11e-129: 400: 23.06		HS74L_HUMAN (1-840): 0: 959: 63.21
+	Hs
		414450 PRGR_HUMAN (232-777): 2.39e-110: 359: 40.00		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		370116 ESR1_HUMAN (263-760): 1.11e-129: 400: 23.06		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		714336 ESR2_HUMAN (286-769): 2.89e-107: 339: 21.34		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		487177 ANDR_HUMAN (357-777): 2.54e-100: 332: 45.15		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		1267724 ESR2_HUMAN (286-769): 2.89e-107: 339: 21.34		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		377052 GCR_HUMAN (1-777): 0: 933: 100.00		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		368878 ESR1_HUMAN (263-760): 1.11e-129: 400: 23.06		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		369084 ESR1_HUMAN (263-760): 1.11e-129: 400: 23.06		HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48
+	Hs
		368938 ESR1_HUMAN (263-760): 1.11e-129: 400: 23.06		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86
+	Hs
		414425 PRGR_HUMAN (232-777): 2.39e-110: 359: 40.00		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		320162 ERR2_HUMAN (316-761): 1.34e-115: 358: 24.44		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		504498 ESR2_HUMAN (286-769): 2.89e-107: 339: 21.34		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		714036 ESR2_HUMAN (286-769): 2.89e-107: 339: 21.34		HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48
+	Hs
		487886 RARA_HUMAN (316-759): 1.61e-105: 333: 19.60		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		487079 ANDR_HUMAN (357-777): 2.54e-100: 332: 45.15		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		503444 NR4A1_HUMAN (268-762): 5.59e-103: 331: 20.88		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		564142 ESR2_HUMAN (286-769): 2.89e-107: 339: 21.34		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86