Interactor 1: PRIO (P04156)
Major prion protein (PrP) (ASCR) (PrP27-30) (PrP33-35C) (CD antigen CD230)
Gene: PRNP

Interactor 2: PRIO (P04156)
Major prion protein (PrP) (ASCR) (PrP27-30) (PrP33-35C) (CD antigen CD230)
Gene: PRNP

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.978

The method score is based on:

Property Details
Experiments 18025469, 18436646, 19204296, 19278656, 32284600, 32514176, 34516876, 21920025, 19927125, 16286452
Identification Methods transmission electron microscopy, electron paramagnetic resonance, atomic force microscopy, nuclear magnetic resonance, cosedimentation in solution, x-ray crystallography, circular dichroism, classical fluorescence spectroscopy, 3D electron microscopy, electron microscopy and 4 others

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Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Prion~Prion
Common GO terms GO:0001540 - amyloid-beta binding
GO:0001933 - negative regulation of protein phosphorylation
GO:0002020 - protease binding
GO:0005507 - copper ion binding
GO:0005521 - lamin binding
and 69 others

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Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 253
Hs

1 253
+ Mm
+ Oc
+ Bt
+ Cl

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024