Interactor 1: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF
Interactor 2: TRADD (Q15628)
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain)
Gene: TRADD
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.96 | 0.60 | 0.762 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 30561431, 27458237, 27307491, 27545878, 12887920, 32968279, 34853447, 12753742, 15485837, 20005846, 16603398, 22099304, 23732909, 24980434, 23955153, 19287455, 21822306, 36179048 |
| Identification Methods | affinity chromatography technology, pull down, anti tag coimmunoprecipitation, virotrap |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005886 - plasma membrane GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors GO:0033209 - tumor necrosis factor-mediated signaling pathway GO:0043065 - positive regulation of apoptotic process GO:0043123 - positive regulation of canonical NF-kappaB signal transduction and 3 others more... |
| Homologous interactions | 1 |
Homologous interactions
Color coding for hit scores 
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Last updated: 11Aug2025
