Protein: TNFA
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]

Gene: TNFA, Tnf
Organism: Mus musculus
Interactions: 36
UniProt ID: P06804

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000976 - transcription cis-regulatory region binding
GO:0001774 - microglial cell activation
GO:0001891 - phagocytic cup
GO:0001934 - positive regulation of protein phosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

449233

TNR1A
Tumor necrosis factor receptor superfamily member 1A

7

20

Small-scale

0.957

High

449240

TF65
Transcription factor p65

14

15

Small-scale

0.757

High

449234

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

20

Small-scale

0.724

High

449245

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

6

14

Small-scale

0.723

High

370834

FOS
Protein c-Fos

2

5

Small-scale

0.601

High

432046

JUN
Transcription factor Jun

2

6

Small-scale

0.601

High

312468

NEMO
NF-kappa-B essential modulator

2

3

Small-scale

0.584

High

449244

TNAP3
Tumor necrosis factor alpha-induced protein 3

2

3

Small-scale

0.584

High

449250

RNF31
E3 ubiquitin-protein ligase RNF31

2

3

Small-scale

0.584

High

81524

B5B2U4
Nuclear factor of activated T-cells c3 isoform IB-Xa

1

16

Small-scale

0.479

High

204814

XBP1
X-box-binding protein 1

1

2

Small-scale

0.479

High

312122

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

6

Small-scale

0.479

High

449228

JUNB
Transcription factor JunB

1

4

Small-scale

0.479

High

449229

IRF1
Interferon regulatory factor 1

1

7

Small-scale

0.479

High

449230

SPI1
Transcription factor PU.1

1

1

Small-scale

0.479

High

449231

CBL
E3 ubiquitin-protein ligase CBL

1

2

Small-scale

0.479

High

449232

IRF8
Interferon regulatory factor 8

1

7

Small-scale

0.479

High

449235

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

7

Small-scale

0.479

High

449239

NOTC1
Neurogenic locus notch homolog protein 1

1

1

Small-scale

0.479

High

449242

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

1

Small-scale

0.479

High

449243

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

3

Small-scale

0.479

High

449246

FADD
FAS-associated death domain protein

1

15

Small-scale

0.479

High

449249

SHRPN
Sharpin

1

3

Small-scale

0.479

High

449252

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

6

Small-scale

0.479

High

449254

TBK1
Serine/threonine-protein kinase TBK1

1

6

Small-scale

0.479

High

449255

TNIP1
TNFAIP3-interacting protein 1

1

3

Small-scale

0.479

High

449256

NFAT5
Nuclear factor of activated T-cells 5

1

16

Small-scale

0.479

High

449247

HDAC4
Histone deacetylase 4

1

0

Small-scale

0.458

High

449248

NRIP1
Nuclear receptor-interacting protein 1

1

0

Small-scale

0.458

High

449227

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

Small-scale

0.437

High

449236

TIA1
Cytotoxic granule associated RNA binding protein TIA1

1

2

Small-scale

0.437

High

449237

TIAR
Nucleolysin TIAR

1

2

Small-scale

0.437

High

449238

ELAV1
ELAV-like protein 1

1

2

Small-scale

0.437

High

449241

RELB
Transcription factor RelB

1

15

Small-scale

0.437

High

449253

TM115
Transmembrane protein 115

1

0

Small-scale

0.261

Low

449251

ZFP64
Zinc finger protein 64

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025