HitPredict

Interactor 1: MYCN (P04198)
N-myc proto-oncogene protein (Class E basic helix-loop-helix protein 37) (bHLHe37)
Gene: MYCN

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	31856871, 20697349
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 464 Hs			1 488
+	Hs
		347485 MYC_HUMAN (7-463): 5.91e-69: 228: 34.16		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		379372 MYCN_HUMAN (1-464): 1.72e-89: 282: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		346718 MYC_HUMAN (7-463): 5.91e-69: 228: 34.16		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		840221 MXI1_HUMAN (341-463): 6.39e-28: 112: 20.33		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		983437 MAD1_HUMAN (347-461): 1.7e-26: 108: 19.66		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		898164 MAX_HUMAN (363-463): 2.41e-25: 103: 33.65		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		177165 MYC_HUMAN (7-463): 5.91e-69: 228: 34.16		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Hs
		738965 SRBP1_HUMAN (86-464): 8.15e-36: 143: 14.25		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		840208 MXI1_HUMAN (341-463): 6.39e-28: 112: 20.33		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		983427 MAD1_HUMAN (347-461): 1.7e-26: 108: 19.66		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Mm
		139901 MNT_MOUSE (286-462): 9.73e-12: 69: 21.86		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		177280 SRBP2_HUMAN (124-459): 1.17e-30: 128: 14.12		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Hs
		348135 MYC_HUMAN (7-463): 5.91e-69: 228: 34.16		HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04