HitPredict

Interactor 1: HLAA (P04439)
HLA class I histocompatibility antigen, A alpha chain (Human leukocyte antigen A) (HLA-A)
Gene: HLA-A

Interactor 2: HLAC (P10321)
HLA class I histocompatibility antigen, C alpha chain (HLA-C) (HLA-Cw) (Human leukocyte antigen C)
Gene: HLA-C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.78 1.00 0.886

The method score is based on:

Property Details
Experiments 26186194, 28514442, 33961781, 17353931
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains C1-set~C1-set, C1-set~MHC_I, MHC_I~MHC_I
Common GO terms GO:0000139 - Golgi membrane
GO:0001916 - positive regulation of T cell mediated cytotoxicity
GO:0002476 - antigen processing and presentation of endogenous peptide antigen via MHC class Ib
GO:0002486 - antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
GO:0005102 - signaling receptor binding
and 18 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 365
Hs

1 366
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024