Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.978

The method score is based on:

Property Details
Experiments 14576349, 8665853, 25315821, 8816440, 11526509, 30898150, 25898135, 19060928, 19077306, 16843263, 17148612, 21203579, 22733765, 21255571
Identification Methods affinity chromatography technology, enzymatic study, two hybrid, pull down, unspecified method, protein complementation assay, protein kinase assay, beta galactosidase complementation, fluorescent resonance energy transfer, anti tag coimmunoprecipitation and 1 others

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Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Furin-like~Furin-like, Furin-like~GF_recep_IV, Furin-like~Recep_L_domain, GF_recep_IV~GF_recep_IV, GF_recep_IV~Recep_L_domain, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, Recep_L_domain~Recep_L_domain
Common GO terms GO:0001042 - RNA polymerase I core binding
GO:0001934 - positive regulation of protein phosphorylation
GO:0002116 - semaphorin receptor complex
GO:0004713 - protein tyrosine kinase activity
GO:0004714 - transmembrane receptor protein tyrosine kinase activity
and 64 others

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Homologous interactions 19

Homologous interactions

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024