HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: INSRR (P14616)
Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
Gene: INSRR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.793

Property	Details
Experiments	30898150, 33961781
Identification Methods	protein complementation assay, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Furin-like~Furin-like, Furin-like~Recep_L_domain, Furin-like~GF_recep_IV, GF_recep_IV~Recep_L_domain, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, Recep_L_domain~Recep_L_domain
Common GO terms	GO:0004714 - transmembrane receptor protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway GO:0043235 - receptor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 1297
+	Hs
		383541 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		IGF1R_HUMAN (9-1265): 0: 1222: 55.39
+	Hs
		383527 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		INSR_HUMAN (27-1288): 0: 1183: 52.18
+	Hs
		383631 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHA3_HUMAN (453-1255): 0: 617: 21.02
+	Hs
		383711 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHB1_HUMAN (455-1277): 0: 616: 20.88
+	Hs
		383712 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHA4_HUMAN (455-1279): 0: 609: 20.55
+	Hs
		383632 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHB2_HUMAN (455-1264): 0: 605: 19.86
+	Hs
		383710 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHA5_HUMAN (454-1279): 0: 591: 19.78
+	Hs
		383709 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHB3_HUMAN (455-1269): 0: 584: 19.64
+	Hs
		383630 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHA2_HUMAN (455-1282): 9.77e-179: 556: 21.20
+	Hs
		171278 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHB6_HUMAN (645-1291): 7.18e-161: 510: 23.91
+	Hs
		383604 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHA1_HUMAN (657-1279): 2.19e-159: 505: 23.51
+	Hs
		384028 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ALK_HUMAN (946-1247): 1.07e-70: 263: 43.46
+	Hs
		383833 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		NTRK2_HUMAN (957-1253): 1.12e-67: 247: 42.43
+	Hs
		383519 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91
+	Hs
		383831 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		NTRK3_HUMAN (957-1242): 2.05e-62: 231: 40.84
+	Hs
		383562 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGFR1_HUMAN (948-1294): 6.81e-59: 221: 35.90
+	Hs
		383606 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ERBB3_HUMAN (2-296): 3.16e-34: 145: 18.24
+	Mm
		936771 ERBB2_MOUSE (1-1255): 0: 1260: 87.66		ERBB3_MOUSE (2-296): 6.89e-33: 140: 18.85
+	Hs
		383821 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ERBB4_HUMAN (342-482): 7.06e-15: 82.4: 19.73
+	Mm
		936769 ERBB2_MOUSE (1-1255): 0: 1260: 87.66		EGFR_MOUSE (320-524): 1.92e-16: 87.4: 14.89