HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: MUC1 (P15941)
Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)]
Gene: MUC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	12939402, 11278868
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0016324 - apical plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1255 Hs			1 1255
+	Hs
		554307 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		MUC1_HUMAN (1-1255): 1.21e-135: 448: 100.00
+	Hs
		337875 EGFR_HUMAN (16-1253): 0: 1070: 48.40		MUC1_HUMAN (1-1255): 1.21e-135: 448: 100.00
+	Hs
		554266 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		MUC1_HUMAN (1-1255): 1.21e-135: 448: 100.00
+	Hs
		383946 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		MUC4_HUMAN (296-1142): 2.14e-16: 87.5: 10.86
+	Hs
		338149 EGFR_HUMAN (16-1253): 0: 1070: 48.40		HCFC1_HUMAN (7-1107): 6.45e-29: 128: 11.01
+	Hs
		1071005 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		MUC4_HUMAN (296-1142): 2.14e-16: 87.5: 10.86
+	Hs
		338965 EGFR_HUMAN (16-1253): 0: 1070: 48.40		TARA_HUMAN (36-1064): 2.31e-23: 110: 8.69
+	Hs
		338878 EGFR_HUMAN (16-1253): 0: 1070: 48.40		MUC4_HUMAN (296-1142): 2.14e-16: 87.5: 10.86
+	Hs
		338874 EGFR_HUMAN (16-1253): 0: 1070: 48.40		MINT_HUMAN (22-1062): 3.99e-14: 80.1: 9.50
+	Hs
		338765 EGFR_HUMAN (16-1253): 0: 1070: 48.40		MUC16_HUMAN (6-1154): 8.49e-11: 69: 9.53
+	Hs
		339147 EGFR_HUMAN (16-1253): 0: 1070: 48.40		SRRM2_HUMAN (105-1020): 1.64e-09: 64.9: 7.41
+	Hs
		601984 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		MUC4_HUMAN (296-1142): 2.14e-16: 87.5: 10.86
+	Hs
		238439 JAK2_HUMAN (216-982): 5.65e-134: 440: 19.75		MUC5B_HUMAN (203-1090): 2.97e-09: 64: 10.14
+	Dm
		1001998 Q0KIF4_DROME (707-990): 1e-52: 204: 39.45		Q9VLS7_DROME (4-946): 1.2e-18: 94.7: 11.85
+	Hs
		983695 FAK1_HUMAN (706-984): 1.9e-53: 206: 39.07		SRRM2_HUMAN (105-1020): 1.64e-09: 64.9: 7.41
+	Hs
		166504 FAK1_HUMAN (706-984): 1.9e-53: 206: 39.07		NACAD_HUMAN (36-1074): 5.89e-09: 63: 13.06
+	Rn
		94371 INSR_RAT (357-634): 2.53e-16: 87.2: 19.87		F1M9G7_RAT (29-1028): 5.45e-21: 102: 12.12
+	Rn
		544878 INSR_RAT (357-634): 2.53e-16: 87.2: 19.87		SPEG_RAT (108-1155): 1.04e-14: 82.1: 10.96
+	Rn
		88946 INSR_RAT (357-634): 2.53e-16: 87.2: 19.87		D4A7D6_RAT (172-1250): 5.6e-12: 72.9: 8.43