HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: CDN2C (P42773)
Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6)
Gene: CDKN2C

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	28205554
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ank_2~GF_recep_IV, Ank_2~Recep_L_domain
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0048709 - oligodendrocyte differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 168
+	Hs
		383675 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		CDN2B_HUMAN (9-122): 1.23e-20: 84: 45.22
+	Hs
		383867 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ANS1B_HUMAN (59-156): 6.65e-16: 76.3: 37.00
+	Hs
		339124 EGFR_HUMAN (16-1253): 0: 1070: 48.40		KDIS_HUMAN (2-159): 8.8e-46: 161: 26.42
+	Hs
		339062 EGFR_HUMAN (16-1253): 0: 1070: 48.40		RAI14_HUMAN (1-135): 3.41e-37: 136: 21.32
+	Hs
		602024 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		KDIS_HUMAN (2-159): 8.8e-46: 161: 26.42
+	Hs
		1070979 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		ANS1B_HUMAN (59-156): 6.65e-16: 76.3: 37.00
+	Hs
		338353 EGFR_HUMAN (16-1253): 0: 1070: 48.40		ANK3_HUMAN (77-168): 3.08e-25: 103: 41.30
+	Hs
		338292 EGFR_HUMAN (16-1253): 0: 1070: 48.40		ANK2_HUMAN (77-168): 1.26e-23: 98.4: 40.22
+	Hs
		338632 EGFR_HUMAN (16-1253): 0: 1070: 48.40		ANS1B_HUMAN (59-156): 6.65e-16: 76.3: 37.00
+	Hs
		601839 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57
+	Hs
		665165 EPHA2_HUMAN (671-1023): 4.87e-117: 390: 33.06		CDN2C_HUMAN (1-168): 3.27e-53: 168: 100.00
+	Hs
		665360 EPHA2_HUMAN (671-1023): 4.87e-117: 390: 33.06		KDIS_HUMAN (2-159): 8.8e-46: 161: 26.42
+	Hs
		434183 RET_HUMAN (426-1088): 3.53e-131: 432: 23.33		ANK3_HUMAN (77-168): 3.08e-25: 103: 41.30
+	Hs
		665591 EPHB2_HUMAN (650-1103): 2.29e-122: 406: 29.47		ANK3_HUMAN (77-168): 3.08e-25: 103: 41.30
+	Hs
		665581 EPHB2_HUMAN (650-1103): 2.29e-122: 406: 29.47		ANK2_HUMAN (77-168): 1.26e-23: 98.4: 40.22
+	Hs
		434233 RET_HUMAN (426-1088): 3.53e-131: 432: 23.33		MIB1_HUMAN (74-168): 4.43e-14: 70.7: 21.88
+	Hs
		665163 EPHA2_HUMAN (671-1023): 4.87e-117: 390: 33.06		CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57
+	Hs
		665164 EPHA2_HUMAN (671-1023): 4.87e-117: 390: 33.06		CDN2B_HUMAN (9-122): 1.23e-20: 84: 45.22
+	Hs
		665280 EPHA2_HUMAN (671-1023): 4.87e-117: 390: 33.06		MIB1_HUMAN (74-168): 4.43e-14: 70.7: 21.88
+	Mm
		1206693 FAK2_MOUSE (707-1006): 9.29e-54: 207: 36.42		ANS1B_MOUSE (59-156): 6.92e-16: 75.9: 37.00