Protein: IMDH4
Inosine-5'-monophosphate dehydrogenase 4 (IMP dehydrogenase 4) (IMPD 4) (IMPDH 4) (EC 1.1.1.205)

Gene: IMDH4, IMD4
Organism: Saccharomyces cerevisiae S288C
Interactions: 160
UniProt ID: P50094

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0003729 - mRNA binding
GO:0003938 - IMP dehydrogenase activity
GO:0005737 - cytoplasm
GO:0006177 - GMP biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

893129

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

8

15

High-throughput

0.970

High

802099

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

3

14

High-throughput

0.855

High

893128

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

3

15

High-throughput

0.843

High

893135

BUD32
EKC/KEOPS complex subunit BUD32

2

2

Small-scale

0.625

High

448762

SNF1
Carbon catabolite-derepressing protein kinase

1

3

Small-scale

0.618

High

812977

IMDH1
Putative inosine-5'-monophosphate dehydrogenase 1

1

14

High-throughput

0.618

High

893179

YRA1
RNA annealing protein YRA1

2

4

Small-scale

0.584

High

752492

HSP78
Heat shock protein 78, mitochondrial

2

1

High-throughput

0.571

High

893139

GIS2
Zinc finger protein GIS2

2

4

High-throughput

0.571

High

524521

HSP71
Heat shock protein SSA1

2

6

High-throughput

0.552

High

819234

SSB2
Ribosome-associated molecular chaperone SSB2

2

8

High-throughput

0.552

High

359034

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

1

High-throughput

0.536

High

403576

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

1

High-throughput

0.536

High

453969

IF4E
Eukaryotic translation initiation factor 4E

1

1

High-throughput

0.536

High

454465

PHO4
Phosphate system positive regulatory protein PHO4

1

1

High-throughput

0.536

High

645466

XRN1
5'-3' exoribonuclease 1

1

4

High-throughput

0.536

High

671424

RNA14
mRNA 3'-end-processing protein RNA14

1

3

High-throughput

0.536

High

722090

XPO1
Exportin-1

1

1

High-throughput

0.536

High

737603

GSH1
Glutamate--cysteine ligase

1

1

High-throughput

0.536

High

738103

MYO4
Myosin-4

1

2

High-throughput

0.536

High

825621

AIR1
Protein AIR1

1

4

High-throughput

0.536

High

893131

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

3

High-throughput

0.536

High

893134

YG5B
Uncharacterized RNA-binding protein YGR250C

1

2

High-throughput

0.536

High

893136

PAP2
Poly(A) RNA polymerase protein 2

1

2

High-throughput

0.536

High

893137

BRE5
UBP3-associated protein BRE5

1

1

High-throughput

0.536

High

893140

ELOA1
Elongin-A

1

1

High-throughput

0.536

High

893146

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

3

High-throughput

0.536

High

893165

MAG2
E3 ubiquitin-protein ligase MAG2

1

2

High-throughput

0.536

High

893171

PUS7
Multisubstrate pseudouridine synthase 7

1

1

High-throughput

0.536

High

893181

RL7B
Large ribosomal subunit protein uL30B

1

2

High-throughput

0.536

High

513109

RS8A
Small ribosomal subunit protein eS8A

2

2

High-throughput

0.533

High

826649

DSN1
Kinetochore-associated protein DSN1

2

2

High-throughput

0.533

High

366821

IPYR
Inorganic pyrophosphatase

1

2

High-throughput

0.515

High

448318

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

1

High-throughput

0.515

High

763844

SKI2
Antiviral helicase SKI2

1

2

High-throughput

0.515

High

893091

YG51
Uncharacterized protein YGR237C

1

1

High-throughput

0.515

High

737331

CDC12
Cell division control protein 12

1

0

High-throughput

0.513

High

780555

SHE2
SWI5-dependent HO expression protein 2

1

0

High-throughput

0.513

High

893161

NKP2
Inner kinetochore subunit NKP2

1

1

High-throughput

0.494

High

359499

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

1

High-throughput

0.489

High

586476

PCNA
Proliferating cell nuclear antigen

1

2

High-throughput

0.489

High

644664

MAG
DNA-3-methyladenine glycosylase

1

2

High-throughput

0.489

High

656983

BUR1
Serine/threonine-protein kinase BUR1

1

2

High-throughput

0.489

High

843247

KRI1
Protein KRI1

1

1

High-throughput

0.489

High

893169

BRX1
Ribosome biogenesis protein BRX1

1

2

High-throughput

0.489

High

893183

SMC6
Structural maintenance of chromosomes protein 6

1

3

High-throughput

0.489

High

149858

RS9A
Small ribosomal subunit protein uS4A

1

3

High-throughput

0.479

High

435223

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

436058

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

438736

SC160
Protein SCP160

1

4

High-throughput

0.479

High

442011

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

512114

RS4A
Small ribosomal subunit protein eS4A

1

1

High-throughput

0.479

High

514726

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

558805

CAF20
Cap-associated protein CAF20

1

2

High-throughput

0.479

High

570073

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

594460

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

Small-scale

0.479

High

674722

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

689077

RL16A
Large ribosomal subunit protein uL13A

1

2

High-throughput

0.479

High

694590

SPT5
Transcription elongation factor SPT5

1

1

High-throughput

0.479

High

738880

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

1

High-throughput

0.479

High

740999

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

5

High-throughput

0.479

High

778429

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

780041

EAP1
Protein EAP1

1

1

High-throughput

0.479

High

792140

GBLP
Small ribosomal subunit protein RACK1

1

4

High-throughput

0.479

High

795454

ATG8
Autophagy-related protein 8

1

3

High-throughput

0.479

High

797761

AIM4
Altered inheritance of mitochondria protein 4

1

2

High-throughput

0.479

High

802274

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.479

High

812081

DHH1
ATP-dependent RNA helicase DHH1

1

2

High-throughput

0.479

High

824918

TM108
Protein TMA108

1

3

High-throughput

0.479

High

850099

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

4

High-throughput

0.479

High

874418

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.479

High

893133

PESC
Pescadillo homolog

1

1

High-throughput

0.479

High

893144

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.479

High

893147

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

893149

XRN2
5'-3' exoribonuclease 2

1

4

High-throughput

0.479

High

893150

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

893168

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.479

High

893170

SGO1
Shugoshin

1

1

High-throughput

0.479

High

893175

TMA46
Translation machinery-associated protein 46

1

2

High-throughput

0.479

High

893178

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.479

High

670916

SIS1
Protein SIS1

1

3

High-throughput

0.470

High

893177

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

427355

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.445

High

481684

HSP73
Heat shock protein SSA3

1

6

High-throughput

0.445

High

527143

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

545519

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.445

High

579724

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.445

High

597205

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.445

High

702262

YJU2
Splicing factor YJU2

1

1

High-throughput

0.445

High

739165

PRP19
Pre-mRNA-processing factor 19

1

5

Small-scale

0.445

High

741952

HSP7F
Heat shock protein homolog SSE1

1

8

High-throughput

0.445

High

794324

PBP2
PAB1-binding protein 2

1

1

High-throughput

0.445

High

795984

NCL1
Multisite-specific tRNA:(cytosine-C(5))-methyltransferase

1

1

High-throughput

0.445

High

806975

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

1

High-throughput

0.445

High

814007

IF2P
Eukaryotic translation initiation factor 5B

1

5

High-throughput

0.445

High

816301

HSP7E
Heat shock protein SSC3, mitochondrial

1

1

High-throughput

0.445

High

863978

JJJ2
J protein JJJ2

1

2

High-throughput

0.445

High

893157

RRP5
rRNA biogenesis protein RRP5

1

4

High-throughput

0.445

High

893180

PUS1
tRNA pseudouridine synthase 1

1

2

High-throughput

0.445

High

382213

H4
Histone H4

1

3

High-throughput

0.437

High

383791

RS17A
Small ribosomal subunit protein eS17A

1

3

High-throughput

0.437

High

410229

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.437

High

433737

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.437

High

455157

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.437

High

503139

RS22A
Small ribosomal subunit protein uS8A

1

3

High-throughput

0.437

High

504311

RL31A
Large ribosomal subunit protein eL31A

1

2

High-throughput

0.437

High

512540

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.437

High

513527

RL1A
Large ribosomal subunit protein uL1A

1

1

High-throughput

0.437

High

677478

KRR1
KRR1 small subunit processome component

1

2

High-throughput

0.437

High

689554

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.437

High

707613

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

747471

RSSA1
Small ribosomal subunit protein uS2A

1

4

High-throughput

0.437

High

753470

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

798691

YB8A
Putative uncharacterized protein YBR285W

1

2

Small-scale

0.437

High

812476

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

844533

UTP10
U3 small nucleolar RNA-associated protein 10

1

2

High-throughput

0.437

High

893141

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

3

High-throughput

0.437

High

893145

NUM1
Nuclear migration protein NUM1

1

4

High-throughput

0.437

High

893152

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.437

High

893154

DHR1
Probable ATP-dependent RNA helicase DHR1

1

3

High-throughput

0.437

High

893158

FAR8
Factor arrest protein 8

1

1

High-throughput

0.437

High

893162

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.437

High

893164

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.437

High

893166

URN1
Pre-mRNA-splicing factor URN1

1

2

High-throughput

0.437

High

893172

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

893174

AP3D
AP-3 complex subunit delta

1

2

High-throughput

0.437

High

893182

DBP10
ATP-dependent RNA helicase DBP10

1

3

High-throughput

0.437

High

452678

ADH3
Alcohol dehydrogenase 3, mitochondrial

1

0

High-throughput

0.426

High

747946

SMY2
Protein SMY2

1

0

High-throughput

0.426

High

893138

IST1
Vacuolar protein sorting-associated protein IST1

1

0

High-throughput

0.426

High

893142

IGO1
mRNA stability protein IGO1

1

0

High-throughput

0.426

High

626809

HSP60
Heat shock protein 60, mitochondrial

1

1

High-throughput

0.407

High

738226

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

1

2

High-throughput

0.407

High

793496

MAK5
ATP-dependent RNA helicase MAK5

1

4

High-throughput

0.407

High

811349

CAJ1
Protein CAJ1

1

1

High-throughput

0.407

High

822960

RFC4
Replication factor C subunit 4

1

2

High-throughput

0.407

High

823274

JEM1
DnaJ-like chaperone JEM1

1

1

High-throughput

0.407

High

863112

RRP41
Exosome complex component SKI6

1

3

High-throughput

0.407

High

864360

SMC3
Structural maintenance of chromosomes protein 3

1

1

High-throughput

0.407

High

893151

GCN5
Histone acetyltransferase GCN5

1

5

High-throughput

0.407

High

893153

CAB5
Dephospho-CoA kinase CAB5

1

2

High-throughput

0.407

High

893159

RRP45
Exosome complex component RRP45

1

3

High-throughput

0.407

High

893167

MHR1
Large ribosomal subunit protein mL67

1

1

High-throughput

0.407

High

893173

NCBP2
Nuclear cap-binding protein subunit 2

1

3

High-throughput

0.407

High

893176

CWC2
Pre-mRNA-splicing factor CWC2

1

2

High-throughput

0.407

High

806939

RPB11
DNA-directed RNA polymerase II subunit RPB11

1

0

High-throughput

0.282

High

502661

RS25B
Small ribosomal subunit protein eS25B

1

0

High-throughput

0.269

Low

893132

COX18
Cytochrome c oxidase assembly protein COX18, mitochondrial

1

0

High-throughput

0.269

Low

513387

RL23B
Large ribosomal subunit protein uL14B

1

0

High-throughput

0.249

Low

893143

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

Small-scale

0.249

Low

893156

POB3
FACT complex subunit POB3

1

0

High-throughput

0.249

Low

893163

PEX30
Peroxisomal membrane protein PEX30

1

0

High-throughput

0.249

Low

568740

RSR1
Ras-related protein RSR1

1

0

High-throughput

0.232

Low

830237

RMRP
Ribonuclease MRP protein subunit SNM1

1

0

High-throughput

0.232

Low

871107

MTR3
Exosome complex component MTR3

1

0

High-throughput

0.232

Low

893130

RTF1
RNA polymerase-associated protein RTF1

1

0

High-throughput

0.232

Low

893148

RT16
Small ribosomal subunit protein bS16m

1

0

High-throughput

0.232

Low

893155

BUD22
Bud site selection protein 22

1

0

High-throughput

0.232

Low

893160

YTH1
mRNA 3'-end-processing protein YTH1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025