HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: DDR1 (Q08345)
Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
Gene: DDR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	30898150
Identification Methods	protein complementation assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms	GO:0004714 - transmembrane receptor protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0043235 - receptor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 913
+	Hs
		383570 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SRC_HUMAN (361-912): 1.28e-125: 391: 23.60
+	Rn
		1225226 Q8K3F9_RAT (1-1255): 0: 1275: 87.98		SRC_RAT (361-912): 4.24e-126: 393: 23.42
+	Hs
		383608 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGFR3_HUMAN (551-905): 1.32e-110: 360: 32.16
+	Hs
		383605 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGFR2_HUMAN (583-905): 4.2e-109: 357: 34.05
+	Hs
		383562 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGFR1_HUMAN (540-905): 6.78e-109: 356: 32.52
+	Hs
		383607 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGFR4_HUMAN (554-910): 8.48e-107: 350: 33.87
+	Hs
		383833 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		NTRK2_HUMAN (604-906): 1.75e-104: 345: 43.89
+	Hs
		383538 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		YES_HUMAN (563-907): 1.25e-105: 339: 31.59
+	Mm
		403432 EGFR_MOUSE (17-1254): 0: 1126: 48.48		SRC_MOUSE (361-912): 1.24e-128: 399: 23.65
+	Hs
		383831 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		NTRK3_HUMAN (607-905): 4.06e-67: 242: 43.63
+	Hs
		383519 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27
+	Rn
		1351588 Q9QX70_RAT (21-1254): 0: 1116: 48.96		SRC_RAT (361-912): 4.24e-126: 393: 23.42
+	Hs
		522997 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		SRC_HUMAN (361-912): 1.28e-125: 391: 23.60
+	Hs
		383527 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		INSR_HUMAN (600-908): 7.71e-53: 202: 37.42
+	Hs
		383541 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		IGF1R_HUMAN (600-908): 4.51e-51: 197: 37.22
+	Hs
		383575 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		INSRR_HUMAN (600-908): 2.79e-50: 194: 38.71
+	Hs
		383749 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ROR2_HUMAN (608-905): 1.57e-50: 194: 38.26
+	Hs
		1070970 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		NTRK2_HUMAN (604-906): 1.75e-104: 345: 43.89
+	Hs
		433359 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		YES_HUMAN (563-907): 1.25e-105: 339: 31.59
+	Hs
		337749 EGFR_HUMAN (16-1253): 0: 1070: 48.40		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27