HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: PTK7 (Q13308)
Inactive tyrosine-protein kinase 7 (Colon carcinoma kinase 4) (CCK-4) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7)
Gene: PTK7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	30898150, 35384245
Identification Methods	protein complementation assay, affinity chromatography technology
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0015026 - coreceptor activity GO:0042060 - wound healing
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 1070
+	Hs
		383519 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		NTRK1_HUMAN (555-1061): 3.09e-57: 214: 30.31
+	Hs
		384028 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ALK_HUMAN (695-1067): 1.21e-52: 204: 32.90
+	Hs
		383605 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGFR2_HUMAN (297-603): 8.71e-43: 170: 18.52
+	Hs
		383608 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGFR3_HUMAN (101-408): 1.28e-38: 157: 20.06
+	Hs
		383562 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGFR1_HUMAN (2-231): 7.15e-34: 142: 12.41
+	Hs
		383763 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		TYRO3_HUMAN (226-605): 4.36e-27: 121: 13.17
+	Hs
		383833 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		NTRK2_HUMAN (43-313): 2.12e-18: 92.8: 16.12
+	Hs
		383831 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		NTRK3_HUMAN (40-228): 3.71e-16: 85.9: 19.10
+	Hs
		383607 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGFR4_HUMAN (2-127): 8.1e-14: 78.2: 17.73
+	Hs
		337749 EGFR_HUMAN (16-1253): 0: 1070: 48.40		NTRK1_HUMAN (555-1061): 3.09e-57: 214: 30.31
+	Hs
		337998 EGFR_HUMAN (16-1253): 0: 1070: 48.40		UFO_HUMAN (21-348): 3.55e-29: 127: 18.80
+	Hs
		1070970 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		NTRK2_HUMAN (43-313): 2.12e-18: 92.8: 16.12
+	Hs
		507855 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		FGFR1_HUMAN (2-231): 7.15e-34: 142: 12.41
+	Hs
		338486 EGFR_HUMAN (16-1253): 0: 1070: 48.40		NTRK2_HUMAN (43-313): 2.12e-18: 92.8: 16.12
+	Hs
		338769 EGFR_HUMAN (16-1253): 0: 1070: 48.40		TITIN_HUMAN (2-145): 6.21e-13: 75.9: 16.22
+	Hs
		384115 RET_HUMAN (426-1088): 3.53e-131: 432: 23.33		NTRK1_HUMAN (555-1061): 3.09e-57: 214: 30.31
+	Hs
		238445 JAK2_HUMAN (216-982): 5.65e-134: 440: 19.75		ALK_HUMAN (695-1067): 1.21e-52: 204: 32.90
+	Hs
		434185 RET_HUMAN (426-1088): 3.53e-131: 432: 23.33		PTK7_HUMAN (2-329): 4.66e-52: 201: 19.94
+	Hs
		238341 JAK2_HUMAN (216-982): 5.65e-134: 440: 19.75		FGFR1_HUMAN (2-231): 7.15e-34: 142: 12.41
+	Hs
		434136 RET_HUMAN (426-1088): 3.53e-131: 432: 23.33		FGFR4_HUMAN (2-127): 8.1e-14: 78.2: 17.73