HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: GRB10 (Q13322)
Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)
Gene: GRB10

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 594
+	Hs
		383805 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRB14_HUMAN (76-594): 0: 575: 55.08
+	Hs
		383806 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRB7_HUMAN (107-594): 1.36e-174: 507: 55.60
+	Hs
		383927 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		Q96D37_HUMAN (36-594): 5.45e-140: 427: 14.11
+	Hs
		383580 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		VAV_HUMAN (36-594): 3.93e-139: 426: 14.11
+	Hs
		383705 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		VAV2_HUMAN (40-588): 1.7e-95: 313: 12.26
+	Hs
		383767 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ITK_HUMAN (293-589): 1.9e-60: 213: 15.47
+	Hs
		145964 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SH2B2_HUMAN (301-581): 7.5e-55: 198: 16.29
+	Hs
		383671 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		TEC_HUMAN (293-590): 2.81e-52: 191: 12.33
+	Hs
		383528 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LCK_HUMAN (420-589): 7.66e-49: 179: 19.66
+	Hs
		383529 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FYN_HUMAN (441-591): 5.64e-47: 174: 20.38
+	Hs
		383538 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		YES_HUMAN (441-592): 9.17e-47: 174: 20.89
+	Hs
		383570 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SRC_HUMAN (443-590): 9.55e-47: 174: 22.08
+	Hs
		383539 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LYN_HUMAN (409-593): 7.45e-46: 171: 17.19
+	Hs
		383547 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		HCK_HUMAN (406-593): 7.97e-46: 171: 18.78
+	Hs
		383551 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGR_HUMAN (441-593): 8.45e-46: 171: 18.63
+	Hs
		383699 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		BLK_HUMAN (449-593): 3.44e-45: 169: 22.82
+	Hs
		383670 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		MATK_HUMAN (454-587): 1.29e-36: 144: 26.81
+	Hs
		383665 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		CSK_HUMAN (454-587): 2.23e-26: 114: 23.19
+	Hs
		383730 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		383682 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		KSYK_HUMAN (459-593): 3.15e-16: 84.1: 27.94