Protein: MDN1
Midasin (Dynein-related AAA-ATPase REA1) (MIDAS-containing protein) (Ribosome export/assembly protein 1)

Gene: MDN1
Organism: Saccharomyces cerevisiae S288C
Interactions: 130
UniProt ID: Q12019

Gene Ontology (top 5):
GO:0000027 - ribosomal large subunit assembly
GO:0000055 - ribosomal large subunit export from nucleus
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

673598

NLE1
Ribosome assembly protein 4

7

19

Small-scale

0.749

High

919037

PESC
Pescadillo homolog

8

1

Small-scale

0.743

High

816928

NUG1
Nuclear GTP-binding protein NUG1

7

5

Small-scale

0.740

High

923222

NOG2
Nucleolar GTP-binding protein 2

7

5

Small-scale

0.740

High

806674

RIX1
Pre-rRNA-processing protein RIX1

9

0

Small-scale

0.721

High

1044237

ARX1
Probable metalloprotease ARX1

6

0

Small-scale

0.695

High

924865

NOP15
Ribosome biogenesis protein 15

4

2

High-throughput

0.691

High

805021

IPI1
Pre-rRNA-processing protein IPI1

4

1

Small-scale

0.689

High

919565

SDA1
Protein SDA1

4

1

Small-scale

0.687

High

803963

CIC1
Proteasome-interacting protein CIC1

4

1

High-throughput

0.686

High

1084112

YTM1
Ribosome biogenesis protein YTM1

3

19

Small-scale

0.665

High

1061409

BUD20
Bud site selection protein 20

4

0

Small-scale

0.664

High

1039653

NOG1
Nucleolar GTP-binding protein 1

3

3

High-throughput

0.656

High

1084111

MDN1
Midasin

1

18

Small-scale

0.647

High

924259

IPI3
Pre-rRNA-processing protein IPI3

3

11

Small-scale

0.646

High

382402

H4
Histone H4

2

12

High-throughput

0.621

High

791129

NOP4
Nucleolar protein 4

2

1

High-throughput

0.621

High

727383

HS104
Heat shock protein 104

1

4

High-throughput

0.618

High

1084113

NOP53
Ribosome biogenesis protein NOP53

3

0

Small-scale

0.613

High

682415

SPB4
ATP-dependent rRNA helicase SPB4

2

3

High-throughput

0.584

High

827634

RLP7
Ribosome biogenesis protein RLP7

2

1

High-throughput

0.584

High

570177

RL3
Large ribosomal subunit protein uL3

2

0

Small-scale

0.559

High

750168

MRT4
Ribosome assembly factor MRT4

2

0

Small-scale

0.559

High

918050

CGR1
rRNA-processing protein CGR1

2

0

Small-scale

0.559

High

527943

HSP72
Heat shock protein SSA2

2

11

High-throughput

0.552

High

744934

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

4

High-throughput

0.541

High

453839

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.536

High

486526

TBA3
Tubulin alpha-3 chain

1

4

High-throughput

0.536

High

651996

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

1

High-throughput

0.536

High

750906

PRS6B
26S proteasome regulatory subunit 6B homolog

1

1

High-throughput

0.536

High

779452

MAOM
NAD-dependent malic enzyme, mitochondrial

1

1

High-throughput

0.536

High

802605

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.536

High

813316

FHP
Flavohemoprotein

1

4

High-throughput

0.536

High

863368

NMD5
Nonsense-mediated mRNA decay protein 5

1

1

High-throughput

0.536

High

915258

ACS2
Acetyl-coenzyme A synthetase 2

1

1

High-throughput

0.536

High

1062882

RBX1
RING-box protein HRT1

1

13

High-throughput

0.536

High

1046128

RRB1
Ribosome assembly protein RRB1

1

15

High-throughput

0.515

High

531421

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.513

High

568940

INO4
Protein INO4

1

0

High-throughput

0.513

High

518153

SSBP1
Single-stranded nucleic acid-binding protein

1

2

High-throughput

0.501

High

793581

TBS1
Uncharacterized transcriptional regulatory protein TBS1

1

0

High-throughput

0.493

High

386900

TBB
Tubulin beta chain

1

5

High-throughput

0.489

High

1084118

HSP42
Heat shock protein 42

1

2

High-throughput

0.489

High

777134

BDF1
Bromodomain-containing factor 1

1

20

High-throughput

0.481

High

364793

CDK1
Cyclin-dependent kinase 1

1

14

High-throughput

0.479

High

367824

ENO1
Enolase 1

1

7

High-throughput

0.479

High

594621

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

671219

SIS1
Protein SIS1

1

6

High-throughput

0.479

High

674883

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

677257

SPB1
27S pre-rRNA

1

10

High-throughput

0.479

High

689158

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.479

High

708459

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

745112

AFG2
ATPase family gene 2 protein

1

7

High-throughput

0.479

High

745906

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

3

High-throughput

0.479

High

818293

NSA2
Ribosome biogenesis protein NSA2

1

1

High-throughput

0.479

High

864546

MTR4
ATP-dependent RNA helicase DOB1

1

2

Small-scale

0.479

High

922659

HST2
NAD-dependent protein deacetylase HST2

1

11

High-throughput

0.479

High

924201

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

20

High-throughput

0.479

High

1025059

NUM1
Nuclear migration protein NUM1

1

19

High-throughput

0.479

High

1038000

NU116
Nucleoporin NUP116/NSP116

1

1

Small-scale

0.479

High

1038116

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.479

High

1040557

ESP1
Separin

1

1

High-throughput

0.479

High

1044497

RUVB1
RuvB-like protein 1

1

4

High-throughput

0.479

High

1047301

ERB1
Ribosome biogenesis protein ERB1

1

15

High-throughput

0.479

High

1053998

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

1060833

RLP24
Ribosome biogenesis protein RLP24

1

1

High-throughput

0.479

High

1084116

RIO1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.479

High

1084117

SIZ2
E3 SUMO-protein ligase SIZ2

1

6

High-throughput

0.479

High

1084120

RUVB2
RuvB-like protein 2

1

4

High-throughput

0.479

High

806095

AP18A
Clathrin coat assembly protein AP180A

1

7

High-throughput

0.470

High

850356

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

1

20

High-throughput

0.470

High

749736

TYE7
Transcription factor TYE7

1

0

High-throughput

0.460

High

1055782

NDE1
Nuclear distribution protein nudE homolog 1

1

0

High-throughput

0.460

High

1056300

HDA2
HDA1 complex subunit 2

1

0

High-throughput

0.460

High

435421

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

436218

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

531920

RL4A
Large ribosomal subunit protein uL4A

1

0

High-throughput

0.458

High

649248

SAN1
Protein SAN1

1

0

Small-scale

0.458

High

735214

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

747709

ATO2
Ammonia transport outward protein 2

1

0

High-throughput

0.458

High

782189

LAS1
Protein LAS1

1

0

Small-scale

0.458

High

782480

RPF2
Ribosome biogenesis protein RPF2

1

0

High-throughput

0.458

High

795857

YBC8
UPF0642 protein YBL028C

1

0

High-throughput

0.458

High

798346

ENP1
Essential nuclear protein 1

1

0

High-throughput

0.458

High

814413

NOC2
Nucleolar complex protein 2

1

0

Small-scale

0.458

High

825398

BMT5
25S rRNA

1

0

High-throughput

0.458

High

826912

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

830207

NOP2
25S rRNA

1

0

High-throughput

0.458

High

864199

ALB1
Ribosome biogenesis protein ALB1

1

0

High-throughput

0.458

High

923067

TR112
Multifunctional methyltransferase subunit TRM112

1

0

Small-scale

0.458

High

1044913

RRP17
Ribosomal RNA-processing protein 17

1

0

High-throughput

0.458

High

1055513

NOC4
Nucleolar complex protein 4

1

0

High-throughput

0.458

High

1064855

RRS1
Regulator of ribosome biosynthesis

1

0

High-throughput

0.458

High

1065567

NIP7
60S ribosome subunit biogenesis protein NIP7

1

0

High-throughput

0.458

High

1084114

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

1084119

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1084121

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.458

High

394988

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.445

High

456466

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

1

High-throughput

0.445

High

546633

SSB1
Ribosome-associated molecular chaperone SSB1

1

11

High-throughput

0.445

High

742613

HSP7F
Heat shock protein homolog SSE1

1

15

High-throughput

0.445

High

802920

DBP8
ATP-dependent RNA helicase DBP8

1

5

High-throughput

0.445

High

893059

PHB2
Prohibitin-2

1

7

High-throughput

0.445

High

918389

TAM41
Phosphatidate cytidylyltransferase, mitochondrial

1

1

High-throughput

0.445

High

758166

CASP
Protein CASP

1

19

High-throughput

0.439

High

809239

END3
Actin cytoskeleton-regulatory complex protein END3

1

2

High-throughput

0.439

High

1056564

IMH1
Golgin IMH1

1

19

High-throughput

0.439

High

503290

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

513272

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

747623

RSSA1
Small ribosomal subunit protein uS2A

1

3

High-throughput

0.437

High

778578

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.437

High

817855

GLE2
mRNA export factor GLE2

1

13

Small-scale

0.437

High

1064815

RS10A
Small ribosomal subunit protein eS10A

1

8

High-throughput

0.437

High

597762

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.426

High

801770

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.426

High

1084115

NSL1
Kinetochore-associated protein NSL1

1

0

High-throughput

0.426

High

814300

RV167
Reduced viability upon starvation protein 167

1

5

High-throughput

0.407

High

836945

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.279

Low

918152

ERG26
Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating

1

0

High-throughput

0.279

Low

1043824

USA1
U1 SNP1-associating protein 1

1

0

High-throughput

0.279

Low

383935

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

433891

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

601151

RL8A
Large ribosomal subunit protein eL8A

1

0

High-throughput

0.249

Low

753639

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

812743

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

1033617

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

1059398

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

782227

GPT2
Glycerol-3-phosphate O-acyltransferase 2

1

0

High-throughput

0.232

Low

1044991

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025