HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: GRB7 (Q14451)
Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)
Gene: GRB7

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.965

Property	Details
Experiments	7907978, 9079677, 17875712, 22973453, 16273093, 12975581, 12061724
Identification Methods	affinity chromatography technology, pull down, unspecified method, nuclear magnetic resonance, protein array, competition binding
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 532
+	Hs
		383805 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRB14_HUMAN (12-532): 0: 614: 47.91
+	Hs
		383780 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRB10_HUMAN (1-532): 0: 593: 53.17
+	Hs
		383927 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		Q96D37_HUMAN (84-526): 8.36e-87: 286: 15.27
+	Hs
		383580 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		VAV_HUMAN (84-526): 4.42e-86: 285: 15.27
+	Hs
		383705 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		VAV2_HUMAN (81-526): 4.93e-78: 264: 14.77
+	Hs
		384022 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		VAV3_HUMAN (81-526): 1.65e-62: 221: 10.44
+	Hs
		383528 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LCK_HUMAN (317-527): 2.74e-57: 200: 20.00
+	Hs
		383767 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ITK_HUMAN (232-527): 1.19e-54: 196: 18.10
+	Hs
		383601 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PLCG1_HUMAN (200-532): 6.64e-50: 187: 14.69
+	Hs
		383529 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FYN_HUMAN (357-529): 5.57e-50: 182: 20.88
+	Hs
		383539 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LYN_HUMAN (347-531): 4.7e-49: 178: 18.46
+	Hs
		383551 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGR_HUMAN (345-527): 5.44e-48: 176: 21.65
+	Hs
		383538 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		YES_HUMAN (366-528): 8.94e-48: 175: 19.53
+	Hs
		383570 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SRC_HUMAN (351-528): 1.08e-46: 172: 24.32
+	Hs
		383547 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		HCK_HUMAN (349-527): 4.62e-45: 168: 19.37
+	Hs
		383977 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SLAP2_HUMAN (355-528): 3.54e-42: 153: 19.55
+	Hs
		383670 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		MATK_HUMAN (398-525): 4.78e-36: 142: 30.37
+	Hs
		383665 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		CSK_HUMAN (394-525): 1.94e-28: 119: 28.78
+	Hs
		383682 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		KSYK_HUMAN (412-531): 6.62e-17: 86: 30.00
+	Hs
		383730 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRB2_HUMAN (427-513): 2.66e-13: 71: 29.89