Protein: LSP1
Sphingolipid long chain base-responsive protein LSP1

Gene: LSP1
Organism: Saccharomyces cerevisiae S288C
Interactions: 169
UniProt ID: Q12230

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005886 - plasma membrane
GO:0006897 - endocytosis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

918725

PIL1
Sphingolipid long chain base-responsive protein PIL1

12

5

Small-scale

0.978

High

1084646

LSP1
Sphingolipid long chain base-responsive protein LSP1

3

5

Small-scale

0.862

High

1042692

PKH1
Serine/threonine-protein kinase PKH1

4

4

Small-scale

0.692

High

776342

MRP8
Uncharacterized protein MRP8

4

1

High-throughput

0.687

High

1046238

SEG1
Eisosome protein SEG1

4

3

Small-scale

0.683

High

1084647

PKH2
Serine/threonine-protein kinase PKH2

3

4

Small-scale

0.664

High

919277

YG3A
Uncharacterized protein YGR130C

3

1

Small-scale

0.658

High

1050322

EIS1
Eisosome protein 1

3

1

Small-scale

0.650

High

645563

XRN1
5'-3' exoribonuclease 1

3

1

High-throughput

0.643

High

742983

HSP79
Heat shock protein homolog SSE2

2

6

High-throughput

0.608

High

822473

TBP6
Probable 26S proteasome subunit YTA6

2

7

High-throughput

0.606

High

671245

SIS1
Protein SIS1

3

1

High-throughput

0.597

High

727402

HS104
Heat shock protein 104

2

3

High-throughput

0.584

High

850262

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.584

High

752885

HSP78
Heat shock protein 78, mitochondrial

2

3

High-throughput

0.571

High

836120

COPB2
Coatomer subunit beta'

2

2

Small-scale

0.561

High

820122

SSB2
Ribosome-associated molecular chaperone SSB2

2

3

High-throughput

0.552

High

1084650

DBP10
ATP-dependent RNA helicase DBP10

2

3

High-throughput

0.548

High

664359

SSD1
Protein SSD1

1

1

High-throughput

0.541

High

687090

PPZ1
Serine/threonine-protein phosphatase PP-Z1

1

1

High-throughput

0.541

High

816102

DLD3
D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3

1

1

High-throughput

0.541

High

932200

ALO
D-arabinono-1,4-lactone oxidase

1

1

High-throughput

0.541

High

1084648

TPO4
Polyamine transporter 4

1

4

High-throughput

0.541

High

811068

TCPD
T-complex protein 1 subunit delta

2

2

High-throughput

0.537

High

525551

HSP71
Heat shock protein SSA1

1

3

High-throughput

0.536

High

709493

HRR25
Casein kinase I homolog HRR25

1

1

High-throughput

0.536

High

924037

ELOA1
Elongin-A

1

1

High-throughput

0.536

High

1044549

VPS64
Vacuolar protein sorting-associated protein 64

1

1

High-throughput

0.536

High

1047348

SEN15
tRNA-splicing endonuclease subunit SEN15

1

1

High-throughput

0.536

High

826933

DSN1
Kinetochore-associated protein DSN1

2

1

High-throughput

0.533

High

625932

HNM1
Choline transporter

1

0

High-throughput

0.518

High

779892

MID2
Cell wall integrity sensor MID2

1

0

High-throughput

0.518

High

817253

EDC2
Enhancer of mRNA-decapping protein 2

1

0

High-throughput

0.518

High

864396

BNA3
Probable kynurenine--oxoglutarate transaminase BNA3

1

0

High-throughput

0.518

High

894381

MUP1
High-affinity methionine permease

1

0

High-throughput

0.518

High

1084652

LSO2
Protein LSO2

1

0

High-throughput

0.518

High

671983

HAL4
Serine/threonine-protein kinase HAL4/SAT4

1

3

High-throughput

0.515

High

734585

MSS51
Protein MSS51, mitochondrial

1

1

High-throughput

0.515

High

738444

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

High-throughput

0.515

High

743653

RTG2
Retrograde regulation protein 2

1

1

High-throughput

0.515

High

760546

FAB1
1-phosphatidylinositol 3-phosphate 5-kinase FAB1

1

1

High-throughput

0.515

High

915387

VPS4
Vacuolar protein sorting-associated protein 4

1

5

High-throughput

0.515

High

917646

MLC1
Myosin light chain 1

1

1

High-throughput

0.515

High

1030269

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

1

High-throughput

0.515

High

1054450

YL179
Uncharacterized protein YLR179C

1

2

High-throughput

0.515

High

1054558

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.513

High

511873

RS24A
Small ribosomal subunit protein eS24A

1

1

High-throughput

0.508

High

1052358

MSC3
Meiotic sister-chromatid recombination protein 3

1

1

High-throughput

0.508

High

660244

AATC
Aspartate aminotransferase, cytoplasmic

1

1

High-throughput

0.494

High

734232

EF2
Elongation factor 2

1

1

High-throughput

0.494

High

798172

ARPC1
Actin-related protein 2/3 complex subunit 1

1

2

High-throughput

0.494

High

926264

PUR91
Bifunctional purine biosynthesis protein ADE16 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase

1

2

High-throughput

0.494

High

660824

PP2A1
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

1

0

High-throughput

0.493

High

684640

CDC20
APC/C activator protein CDC20

1

0

High-throughput

0.493

High

704903

KIP2
Kinesin-like protein KIP2

1

0

High-throughput

0.493

High

732877

GLPK
Glycerol kinase

1

0

High-throughput

0.493

High

736609

RIM1
Single-stranded DNA-binding protein RIM1, mitochondrial

1

0

High-throughput

0.493

High

1052209

POC1
Proteasome chaperone 1

1

0

High-throughput

0.493

High

448419

RAD1
DNA repair protein RAD1

1

1

High-throughput

0.489

High

1084440

YP150
Putative serine/threonine-protein kinase YPL150W

1

3

High-throughput

0.489

High

361021

CCPR
Cytochrome c peroxidase, mitochondrial

1

0

High-throughput

0.486

High

744509

KA122
Importin beta-like protein KAP122

1

1

Small-scale

0.481

High

150014

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.479

High

435437

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

436232

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

510907

HSP77
Import motor subunit, mitochondrial

1

2

High-throughput

0.479

High

514890

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

645282

GAS1
1,3-beta-glucanosyltransferase GAS1

1

1

High-throughput

0.479

High

647248

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.479

High

672599

YCP4
Flavoprotein-like protein YCP4

1

3

High-throughput

0.479

High

674894

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

680163

CDC48
Cell division control protein 48

1

1

High-throughput

0.479

High

710045

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

739491

ZUO1
Zuotin

1

1

Small-scale

0.479

High

746970

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

1

High-throughput

0.479

High

758492

SEG2
Eisosome protein SEG2

1

3

High-throughput

0.479

High

778592

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

781478

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.479

High

792311

GBLP
Small ribosomal subunit protein RACK1

1

1

High-throughput

0.479

High

795594

ATG8
Autophagy-related protein 8

1

1

High-throughput

0.479

High

796554

ECM33
Cell wall protein ECM33

1

1

High-throughput

0.479

High

797803

AIM4
Altered inheritance of mitochondria protein 4

1

1

High-throughput

0.479

High

802448

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

806388

KOG1
Target of rapamycin complex 1 subunit KOG1

1

1

Small-scale

0.479

High

812768

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

815611

RSP5
E3 ubiquitin-protein ligase RSP5

1

3

High-throughput

0.479

High

818661

FMP10
Uncharacterized mitochondrial membrane protein FMP10

1

1

High-throughput

0.479

High

826361

INP51
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP51

1

1

Small-scale

0.479

High

863837

ATG27
Autophagy-related protein 27

1

1

High-throughput

0.479

High

874591

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

881468

TOM22
Mitochondrial import receptor subunit TOM22

1

1

High-throughput

0.479

High

923894

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.479

High

925398

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

1028046

ACAC
Acetyl-CoA carboxylase

1

2

Small-scale

0.479

High

1033632

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

1042272

TOM1
E3 ubiquitin-protein ligase TOM1

1

3

High-throughput

0.479

High

1049999

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

1

High-throughput

0.479

High

1050093

RTN1
Reticulon-like protein 1

1

1

Small-scale

0.479

High

1084373

ATG9
Autophagy-related protein 9

1

1

High-throughput

0.479

High

1084649

PST2
Protoplast secreted protein 2

1

3

High-throughput

0.479

High

1084651

LAS17
Proline-rich protein LAS17

1

1

Small-scale

0.479

High

797166

AIM3
Altered inheritance of mitochondria protein 3

1

1

High-throughput

0.470

High

902686

RL9B
Large ribosomal subunit protein uL6B

1

2

High-throughput

0.470

High

1055168

CORO
Coronin-like protein

1

1

High-throughput

0.470

High

502677

RS25B
Small ribosomal subunit protein eS25B

1

2

High-throughput

0.464

High

864284

TAX4
Protein TAX4

1

1

High-throughput

0.464

High

1084653

RS25A
Small ribosomal subunit protein eS25A

1

2

High-throughput

0.464

High

577245

SEC63
Protein translocation protein SEC63

1

0

Small-scale

0.460

High

924276

RHO5
GTP-binding protein RHO5

1

0

Small-scale

0.460

High

672983

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

748788

YPT7
Ypt/Rab-type GTPase YPT7

1

0

Small-scale

0.458

High

796688

IST2
Increased sodium tolerance protein 2

1

0

High-throughput

0.458

High

917005

MDM34
Mitochondrial distribution and morphology protein 34

1

0

Small-scale

0.458

High

720857

ITR1
Myo-inositol transporter 1

1

3

High-throughput

0.457

High

365228

KPYK1
Pyruvate kinase 1

1

1

High-throughput

0.445

High

528018

HSP72
Heat shock protein SSA2

1

3

High-throughput

0.445

High

546745

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.445

High

580248

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.445

High

592581

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.445

High

742676

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.445

High

818212

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

1

High-throughput

0.445

High

824586

6P21
6-phosphofructo-2-kinase 1

1

2

High-throughput

0.445

High

513794

RL2A
Large ribosomal subunit protein uL2A

1

1

High-throughput

0.439

High

843236

ZIM17
Mitochondrial protein import protein ZIM17

1

0

High-throughput

0.438

High

1054066

YL326
Uncharacterized membrane protein YLR326W

1

0

High-throughput

0.438

High

383949

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

410397

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

433904

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

442172

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.437

High

455319

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.437

High

747637

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.437

High

503304

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

512715

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.437

High

513284

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

689724

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.437

High

708530

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

753654

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

919050

PESC
Pescadillo homolog

1

1

High-throughput

0.437

High

922134

COPA
Coatomer subunit alpha

1

2

Small-scale

0.437

High

963791

H3
Histone H3

1

1

High-throughput

0.437

High

1044508

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.437

High

1054437

SEC10
Exocyst complex component SEC10

1

1

Small-scale

0.437

High

1054871

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.437

High

1055569

URN1
Pre-mRNA-splicing factor URN1

1

1

High-throughput

0.437

High

1064828

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.437

High

671741

SCJ1
DnaJ-related protein SCJ1

1

0

High-throughput

0.426

High

865972

DPH4
Diphthamide biosynthesis protein 4

1

0

High-throughput

0.426

High

1065613

FLC1
Flavin carrier protein 1

2

0

High-throughput

0.319

High

918497

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.282

High

922989

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

High-throughput

0.282

High

625058

PRP6
Pre-mRNA-splicing factor 6

1

0

High-throughput

0.279

Low

924930

APP1
Phosphatidate phosphatase APP1

1

0

High-throughput

0.279

Low

657015

BUR1
Serine/threonine-protein kinase BUR1

1

0

High-throughput

0.269

Low

754731

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

0

High-throughput

0.269

Low

796473

SLT11
Pre-mRNA-splicing factor SLT11

1

0

High-throughput

0.269

Low

814156

SAW1
Single-strand annealing weakened protein 1

1

0

High-throughput

0.269

Low

844496

GZF3
Protein GZF3

1

0

High-throughput

0.269

Low

1033906

PRS8
26S proteasome regulatory subunit 8 homolog

1

0

High-throughput

0.269

Low

818298

NSA2
Ribosome biogenesis protein NSA2

1

0

High-throughput

0.265

Low

1042461

PRP3
U4/U6 small nuclear ribonucleoprotein PRP3

1

0

High-throughput

0.265

Low

1084260

MLH3
DNA mismatch repair protein MLH3

1

0

High-throughput

0.265

Low

1064653

ESA1
Histone acetyltransferase ESA1

1

0

Small-scale

0.261

Low

817825

NU157
Nucleoporin NUP157

1

0

High-throughput

0.249

Low

836036

COPB
Coatomer subunit beta

1

0

Small-scale

0.249

Low

865790

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

1044099

NUP53
Nucleoporin NUP53

1

0

High-throughput

0.249

Low

1054010

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

1035202

UBC7
Ubiquitin-conjugating enzyme E2 7

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025