HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: ANS1A (Q92625)
Ankyrin repeat and SAM domain-containing protein 1A (Odin)
Gene: ANKS1A

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	16273093
Identification Methods	unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ank_2~GF_recep_IV, PK_Tyr_Ser-Thr~SAM_1, Ank_2~Recep_L_domain
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1255 Hs			1 1134
+	Hs
		1070992 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		ANS1A_HUMAN (1-1134): 0: 792: 100.00
+	Hs
		383867 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ANS1B_HUMAN (1-1101): 0: 593: 33.52
+	Hs
		338786 EGFR_HUMAN (16-1253): 0: 1070: 48.40		ANS1A_HUMAN (1-1134): 0: 792: 100.00
+	Hs
		1070979 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		ANS1B_HUMAN (1-1101): 0: 593: 33.52
+	Hs
		338632 EGFR_HUMAN (16-1253): 0: 1070: 48.40		ANS1B_HUMAN (1-1101): 0: 593: 33.52
+	Hs
		339124 EGFR_HUMAN (16-1253): 0: 1070: 48.40		KDIS_HUMAN (121-538): 2.01e-56: 216: 15.20
+	Hs
		602024 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		KDIS_HUMAN (121-538): 2.01e-56: 216: 15.20
+	Hs
		338353 EGFR_HUMAN (16-1253): 0: 1070: 48.40		ANK3_HUMAN (183-812): 9.9e-38: 157: 12.04
+	Hs
		338292 EGFR_HUMAN (16-1253): 0: 1070: 48.40		ANK2_HUMAN (180-837): 1.86e-34: 146: 13.55
+	Mm
		1206693 FAK2_MOUSE (707-1006): 9.29e-54: 207: 36.42		ANS1B_MOUSE (1-1133): 0: 621: 33.57
+	Hs
		665635 EPHB2_HUMAN (650-1103): 2.29e-122: 406: 29.47		CSKI2_HUMAN (1-592): 3.95e-69: 255: 24.71
+	Hs
		665360 EPHA2_HUMAN (671-1023): 4.87e-117: 390: 33.06		KDIS_HUMAN (121-538): 2.01e-56: 216: 15.20
+	Hs
		434233 RET_HUMAN (426-1088): 3.53e-131: 432: 23.33		MIB1_HUMAN (3-343): 1.07e-41: 168: 22.32
+	Hs
		434183 RET_HUMAN (426-1088): 3.53e-131: 432: 23.33		ANK3_HUMAN (183-812): 9.9e-38: 157: 12.04
+	Hs
		665591 EPHB2_HUMAN (650-1103): 2.29e-122: 406: 29.47		ANK3_HUMAN (183-812): 9.9e-38: 157: 12.04
+	Hs
		665280 EPHA2_HUMAN (671-1023): 4.87e-117: 390: 33.06		MIB1_HUMAN (3-343): 1.07e-41: 168: 22.32
+	Hs
		665581 EPHB2_HUMAN (650-1103): 2.29e-122: 406: 29.47		ANK2_HUMAN (180-837): 1.86e-34: 146: 13.55
+	Hs
		872504 EPHA5_HUMAN (707-1010): 2.37e-53: 206: 37.46		KDIS_HUMAN (121-538): 2.01e-56: 216: 15.20
+	Hs
		983635 FAK1_HUMAN (706-984): 1.9e-53: 206: 39.07		ANKH1_HUMAN (2-106): 1.43e-14: 81.3: 23.81