Protein: MAK21
Ribosome biogenesis protein MAK21 (Maintenance of killer protein 21) (Nucleolar complex protein 1)

Gene: MAK21
Organism: Saccharomyces cerevisiae S288C
Interactions: 214
UniProt ID: Q12176

Gene Ontology (top 5):
GO:0000027 - ribosomal large subunit assembly
GO:0003729 - mRNA binding
GO:0005634 - nucleus
GO:0005730 - nucleolus
GO:0030687 - preribosome, large subunit precursor

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

814418

NOC2
Nucleolar complex protein 2

18

6

Small-scale

0.987

High

830213

NOP2
25S rRNA

4

6

Small-scale

0.892

High

1065572

NIP7
60S ribosome subunit biogenesis protein NIP7

3

3

High-throughput

0.855

High

677261

SPB1
27S pre-rRNA

2

4

High-throughput

0.767

High

1050208

RRP5
rRNA biogenesis protein RRP5

11

4

Small-scale

0.757

High

804689

SSF1
Ribosome biogenesis protein SSF1

11

4

Small-scale

0.752

High

919047

PESC
Pescadillo homolog

10

4

Small-scale

0.751

High

1043315

HAS1
ATP-dependent RNA helicase HAS1

9

18

High-throughput

0.751

High

782490

RPF2
Ribosome biogenesis protein RPF2

8

2

Small-scale

0.748

High

791133

NOP4
Nucleolar protein 4

7

3

High-throughput

0.748

High

827642

RLP7
Ribosome biogenesis protein RLP7

7

7

High-throughput

0.743

High

1084544

RRP12
Ribosomal RNA-processing protein 12

6

3

High-throughput

0.730

High

803968

CIC1
Proteasome-interacting protein CIC1

6

4

High-throughput

0.729

High

1084127

YTM1
Ribosome biogenesis protein YTM1

6

7

High-throughput

0.729

High

844661

UTP10
U3 small nucleolar RNA-associated protein 10

6

2

High-throughput

0.722

High

585406

FBRL
rRNA 2'-O-methyltransferase fibrillarin

5

4

High-throughput

0.714

High

793547

MAK5
ATP-dependent RNA helicase MAK5

5

14

High-throughput

0.712

High

1047306

ERB1
Ribosome biogenesis protein ERB1

5

7

High-throughput

0.712

High

1084534

MAK21
Ribosome biogenesis protein MAK21

5

4

High-throughput

0.707

High

758273

URB1
Nucleolar pre-ribosomal-associated protein 1

5

1

Small-scale

0.704

High

924870

NOP15
Ribosome biogenesis protein 15

4

6

High-throughput

0.691

High

1054412

DBP9
ATP-dependent RNA helicase DBP9

4

11

High-throughput

0.691

High

1062352

NOP12
Nucleolar protein 12

4

9

High-throughput

0.691

High

1062794

BRX1
Ribosome biogenesis protein BRX1

4

16

High-throughput

0.691

High

746695

DRS1
ATP-dependent RNA helicase DRS1

4

14

High-throughput

0.680

High

816814

NOP16
Nucleolar protein 16

4

2

High-throughput

0.680

High

1039662

NOG1
Nucleolar GTP-binding protein 1

4

3

High-throughput

0.680

High

917585

NSA1
Ribosome biogenesis protein NSA1

4

3

Small-scale

0.676

High

923227

NOG2
Nucleolar GTP-binding protein 2

3

9

High-throughput

0.670

High

763651

UTP20
U3 small nucleolar RNA-associated protein 20

3

1

High-throughput

0.662

High

1053102

RSA3
Ribosome assembly protein 3

4

0

Small-scale

0.661

High

780346

EBP2
rRNA-processing protein EBP2

3

3

High-throughput

0.658

High

1064861

RRS1
Regulator of ribosome biosynthesis

3

5

High-throughput

0.646

High

1084241

NOP53
Ribosome biogenesis protein NOP53

3

2

High-throughput

0.646

High

1084538

DBP10
ATP-dependent RNA helicase DBP10

3

8

High-throughput

0.646

High

816566

SNU13
13 kDa ribonucleoprotein-associated protein

3

7

High-throughput

0.643

High

751511

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

3

2

High-throughput

0.640

High

763142

RRP1
Ribosomal RNA-processing protein 1

3

6

Small-scale

0.640

High

923034

DBP6
ATP-dependent RNA helicase DBP6

3

15

Small-scale

0.640

High

1062933

NOP8
60S ribosome subunit biogenesis protein NOP8

3

1

Small-scale

0.640

High

1084540

NOP58
Nucleolar protein 58

3

9

High-throughput

0.640

High

850041

LOC1
60S ribosomal subunit assembly/export protein LOC1

2

2

High-throughput

0.634

High

1055484

RRP15
Ribosomal RNA-processing protein 15

2

2

High-throughput

0.634

High

432736

RL7A
Large ribosomal subunit protein uL30A

2

7

High-throughput

0.611

High

531930

RL4A
Large ribosomal subunit protein uL4A

2

3

High-throughput

0.611

High

570187

RL3
Large ribosomal subunit protein uL3

2

3

High-throughput

0.611

High

689163

RL16A
Large ribosomal subunit protein uL13A

2

5

High-throughput

0.611

High

917509

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

2

2

High-throughput

0.611

High

525524

HSP71
Heat shock protein SSA1

2

6

High-throughput

0.601

High

546714

SSB1
Ribosome-associated molecular chaperone SSB1

2

5

High-throughput

0.601

High

864556

MTR4
ATP-dependent RNA helicase DOB1

2

2

Small-scale

0.601

High

805113

RPF1
Ribosome production factor 1

2

4

High-throughput

0.594

High

818296

NSA2
Ribosome biogenesis protein NSA2

2

2

High-throughput

0.594

High

534164

MAK16
Protein MAK16

2

5

High-throughput

0.584

High

677617

KRR1
KRR1 small subunit processome component

2

3

High-throughput

0.584

High

682425

SPB4
ATP-dependent rRNA helicase SPB4

2

17

High-throughput

0.584

High

750174

MRT4
Ribosome assembly factor MRT4

2

7

High-throughput

0.584

High

798352

ENP1
Essential nuclear protein 1

2

3

High-throughput

0.584

High

806680

RIX1
Pre-rRNA-processing protein RIX1

2

2

Small-scale

0.584

High

826930

DSN1
Kinetochore-associated protein DSN1

2

1

High-throughput

0.584

High

1046825

UTP14
U3 small nucleolar RNA-associated protein 14

2

2

High-throughput

0.584

High

1053536

UTP21
U3 small nucleolar RNA-associated protein 21

2

7

High-throughput

0.584

High

1062807

REXO4
RNA exonuclease 4

2

3

High-throughput

0.584

High

1065600

BMS1
Ribosome biogenesis protein BMS1

2

3

High-throughput

0.584

High

1084539

NOP56
Nucleolar protein 56

2

9

High-throughput

0.584

High

403699

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

2

2

Small-scale

0.571

High

436229

RS13
Small ribosomal subunit protein uS15

2

2

High-throughput

0.571

High

918053

CGR1
rRNA-processing protein CGR1

2

0

High-throughput

0.569

High

383208

RLA4
Large ribosomal subunit protein P2B

2

1

High-throughput

0.567

High

486529

TBA3
Tubulin alpha-3 chain

2

0

High-throughput

0.563

High

921139

DCP2
m7GpppN-mRNA hydrolase

2

0

High-throughput

0.563

High

527998

HSP72
Heat shock protein SSA2

2

6

High-throughput

0.552

High

383375

RL28
Large ribosomal subunit protein uL15

1

1

High-throughput

0.536

High

433090

RL6B
Large ribosomal subunit protein eL6B

1

2

High-throughput

0.536

High

442168

RS14A
Small ribosomal subunit protein uS11A

1

4

High-throughput

0.536

High

684883

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.536

High

722352

XPO1
Exportin-1

1

3

High-throughput

0.536

High

831840

RL33B
Large ribosomal subunit protein eL33B

1

1

High-throughput

0.536

High

863895

RL17B
Large ribosomal subunit protein uL22B

1

4

High-throughput

0.536

High

918347

RL26B
Large ribosomal subunit protein uL24B

1

4

High-throughput

0.536

High

923153

BRE5
UBP3-associated protein BRE5

1

1

High-throughput

0.536

High

1030607

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

2

High-throughput

0.536

High

1053620

MRD1
Multiple RNA-binding domain-containing protein 1

1

6

Small-scale

0.536

High

1084545

RL11B
Large ribosomal subunit protein uL5B

1

4

High-throughput

0.536

High

504472

RL31A
Large ribosomal subunit protein eL31A

2

5

High-throughput

0.533

High

514887

RS18A
Small ribosomal subunit protein uS13A

2

2

High-throughput

0.533

High

632764

DBP4
ATP-dependent RNA helicase HCA4

1

17

High-throughput

0.515

High

781668

DBP7
ATP-dependent RNA helicase DBP7

1

15

High-throughput

0.515

High

676685

SGF29
SAGA complex subunit SGF29

1

0

High-throughput

0.513

High

518157

SSBP1
Single-stranded nucleic acid-binding protein

1

2

High-throughput

0.501

High

813772

OAF1
Oleate-activated transcription factor 1

1

0

High-throughput

0.493

High

154240

RL36B
Large ribosomal subunit protein eL36B

1

3

High-throughput

0.489

High

434461

RL15A
Large ribosomal subunit protein eL15A

1

2

High-throughput

0.489

High

511870

RS24A
Small ribosomal subunit protein eS24A

1

3

High-throughput

0.489

High

569883

RL30
Large ribosomal subunit protein eL30

1

2

High-throughput

0.489

High

712698

RL8B
Large ribosomal subunit protein eL8B

1

7

High-throughput

0.489

High

820982

RL13B
Large ribosomal subunit protein eL13B

1

4

High-throughput

0.489

High

1040432

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

1

3

High-throughput

0.489

High

1084543

RL13A
Large ribosomal subunit protein eL13A

1

4

High-throughput

0.489

High

1084546

RS22B
Small ribosomal subunit protein uS8B

1

2

High-throughput

0.489

High

1084537

SMT3
Ubiquitin-like protein SMT3

1

2

High-throughput

0.481

High

150010

RS9A
Small ribosomal subunit protein uS4A

1

3

High-throughput

0.479

High

382411

H4
Histone H4

1

1

High-throughput

0.479

High

410392

RL25
Large ribosomal subunit protein uL23

1

4

High-throughput

0.479

High

419906

H2A2
Histone H2A.2

1

4

High-throughput

0.479

High

433901

RL26A
Large ribosomal subunit protein uL24A

1

4

High-throughput

0.479

High

435433

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

513792

RL2A
Large ribosomal subunit protein uL2A

1

4

High-throughput

0.479

High

514382

RL12B
Large ribosomal subunit protein uL11B

1

1

High-throughput

0.479

High

632605

DBP3
ATP-dependent RNA helicase DBP3

1

4

High-throughput

0.479

High

633206

MAK11
Protein MAK11

1

7

High-throughput

0.479

High

637305

PWP1
Periodic tryptophan protein 1

1

8

High-throughput

0.479

High

645011

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

1

High-throughput

0.479

High

671236

SIS1
Protein SIS1

1

1

High-throughput

0.479

High

672981

RRP43
Exosome complex component RRP43

1

2

High-throughput

0.479

High

677984

YCQ6
Uncharacterized protein YCR016W

1

1

High-throughput

0.479

High

678484

PWP2
Periodic tryptophan protein 2

1

7

High-throughput

0.479

High

692645

NSR1
Nuclear localization sequence-binding protein

1

3

High-throughput

0.479

High

700308

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

1

High-throughput

0.479

High

708512

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

735226

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

738277

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

1

7

High-throughput

0.479

High

754355

DCA13
Protein SOF1

1

7

High-throughput

0.479

High

780725

RRP14
Ribosomal RNA-processing protein 14

1

2

High-throughput

0.479

High

802445

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.479

High

807178

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

6

High-throughput

0.479

High

816933

NUG1
Nuclear GTP-binding protein NUG1

1

9

High-throughput

0.479

High

823060

ATAD2
ATPase histone chaperone YTA7

1

4

High-throughput

0.479

High

843289

KRI1
Protein KRI1

1

2

High-throughput

0.479

High

864984

NOP9
Nucleolar protein 9

1

1

Small-scale

0.479

High

865193

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

2

High-throughput

0.479

High

865433

URB2
Nucleolar pre-ribosomal-associated protein 2

1

1

High-throughput

0.479

High

874237

TRF5
Poly(A) RNA polymerase protein 1

1

1

Small-scale

0.479

High

918494

EIF2A
Eukaryotic translation initiation factor 2A

1

1

High-throughput

0.479

High

918857

UTP22
U3 small nucleolar RNA-associated protein 22

1

2

High-throughput

0.479

High

919783

YG5X
Putative methyltransferase YGR283C

1

1

High-throughput

0.479

High

922187

PAP2
Poly(A) RNA polymerase protein 2

1

1

Small-scale

0.479

High

924073

JJJ1
J protein JJJ1

1

3

Small-scale

0.479

High

924205

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

5

High-throughput

0.479

High

924353

NOP13
Nucleolar protein 13

1

2

High-throughput

0.479

High

924662

NAT10
RNA cytidine acetyltransferase

1

2

High-throughput

0.479

High

925133

APJ1
J domain-containing protein APJ1

1

4

High-throughput

0.479

High

963787

H3
Histone H3

1

4

High-throughput

0.479

High

1028619

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

2

High-throughput

0.479

High

1031076

NOP3
Serine/arginine

1

11

High-throughput

0.479

High

1039876

UTP17
NET1-associated nuclear protein 1

1

10

High-throughput

0.479

High

1046088

DHR1
Probable ATP-dependent RNA helicase DHR1

1

2

High-throughput

0.479

High

1046276

UTP15
U3 small nucleolar RNA-associated protein 15

1

6

High-throughput

0.479

High

1049095

YM91
Putative methyltransferase YMR310C

1

1

High-throughput

0.479

High

1053134

UTP13
U3 small nucleolar RNA-associated protein 13

1

10

High-throughput

0.479

High

1055448

RRP9
Ribosomal RNA-processing protein 9

1

7

High-throughput

0.479

High

1055522

NOC4
Nucleolar complex protein 4

1

4

High-throughput

0.479

High

1059620

NOP6
Nucleolar protein 6

1

1

High-throughput

0.479

High

1060421

RIX7
Ribosome biogenesis ATPase RIX7

1

2

High-throughput

0.479

High

1064291

SGO1
Shugoshin

1

2

High-throughput

0.479

High

1084415

RRP6
Exosome complex exonuclease RRP6

1

3

High-throughput

0.479

High

1084536

UTP12
U3 small nucleolar RNA-associated protein 12

1

7

High-throughput

0.479

High

1084541

CMR1
DNA damage-binding protein CMR1

1

6

High-throughput

0.479

High

1084542

IF6
Eukaryotic translation initiation factor 6

1

3

Small-scale

0.479

High

1084547

NOP10
H/ACA ribonucleoprotein complex subunit NOP10

1

1

High-throughput

0.479

High

1084548

NOP14
Nucleolar complex protein 14

1

2

High-throughput

0.479

High

534323

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

0

High-throughput

0.458

High

739560

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

0

High-throughput

0.458

High

826111

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.458

High

1042269

TOM1
E3 ubiquitin-protein ligase TOM1

1

0

High-throughput

0.458

High

1084535

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

393515

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.445

High

427484

RLA0
Large ribosomal subunit protein uL10

1

7

High-throughput

0.445

High

444652

DED1
ATP-dependent RNA helicase DED1

1

2

High-throughput

0.445

High

689297

RL16B
Large ribosomal subunit protein uL13B

1

5

High-throughput

0.445

High

689721

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.445

High

742660

HSP7F
Heat shock protein homolog SSE1

1

9

High-throughput

0.445

High

763042

SPT7
SAGA complex subunit SPT7

1

3

High-throughput

0.445

High

804557

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.445

High

811430

CAJ1
Protein CAJ1

1

1

High-throughput

0.445

High

835916

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.445

High

1036358

ADA2
SAGA complex subunit ADA2

1

1

High-throughput

0.445

High

1046540

PUF6
Pumilio homology domain family member 6

1

2

Small-scale

0.445

High

455316

RS19A
Small ribosomal subunit protein eS19A

1

5

High-throughput

0.437

High

503864

RL27A
Large ribosomal subunit protein eL27A

1

1

High-throughput

0.437

High

511314

RL20B
Large ribosomal subunit protein eL20B

1

3

High-throughput

0.437

High

513592

RL1A
Large ribosomal subunit protein uL1A

1

7

High-throughput

0.437

High

514076

RL18B
Large ribosomal subunit protein eL18B

1

3

High-throughput

0.437

High

514203

RS16B
Small ribosomal subunit protein uS9B

1

1

High-throughput

0.437

High

558902

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

753650

RS3A1
Small ribosomal subunit protein eS1A

1

4

High-throughput

0.437

High

778589

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.437

High

785997

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.437

High

812762

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

874588

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.437

High

1033629

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.437

High

1043933

BUL2
Ubiquitin ligase-binding protein BUL2

1

1

Small-scale

0.437

High

1046329

VMS1
tRNA endonuclease VMS1

1

4

High-throughput

0.437

High

1046959

POB3
FACT complex subunit POB3

1

1

High-throughput

0.437

High

1059415

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

1064825

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.437

High

893255

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.426

High

1042399

GCN5
Histone acetyltransferase GCN5

1

0

High-throughput

0.426

High

395009

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.407

High

570322

RS17B
Small ribosomal subunit protein eS17B

1

2

High-throughput

0.407

High

655532

RS3A2
Small ribosomal subunit protein eS1B

1

4

High-throughput

0.407

High

747634

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.407

High

752880

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.407

High

1052945

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

8

High-throughput

0.407

High

916822

YOR1
Oligomycin resistance ATP-dependent permease YOR1

2

0

High-throughput

0.324

High

453845

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.279

Low

814060

IF2P
Eukaryotic translation initiation factor 5B

1

0

High-throughput

0.269

Low

477650

MYO1
Myosin-1

1

0

Small-scale

0.249

Low

386911

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

592577

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

836956

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low

863782

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

865105

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025