HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: PTPRU (Q92729)
Receptor-type tyrosine-protein phosphatase U (R-PTP-U) (EC 3.1.3.48) (Pancreatic carcinoma phosphatase 2) (PCP-2) (Protein-tyrosine phosphatase J) (PTP-J) (hPTP-J) (Protein-tyrosine phosphatase pi) (PTP pi) (Protein-tyrosine phosphatase receptor omicron) (PTP-RO) (Receptor-type protein-tyrosine phosphatase psi) (R-PTP-psi)
Gene: PTPRU

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	28065597
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Furin-like~fn3, PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~Y_phosphatase, Recep_L_domain~fn3
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 1446
+	Hs
		383818 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRK_HUMAN (26-1442): 0: 1098: 59.48
+	Hs
		383597 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRA_HUMAN (673-1443): 0: 755: 28.46
+	Hs
		383612 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRG_HUMAN (295-1445): 0: 670: 21.71
+	Hs
		337909 EGFR_HUMAN (16-1253): 0: 1070: 48.40		PTPRA_HUMAN (673-1443): 0: 755: 28.46
+	Hs
		337942 EGFR_HUMAN (16-1253): 0: 1070: 48.40		PTPRE_HUMAN (776-1440): 0: 723: 32.15
+	Hs
		337943 EGFR_HUMAN (16-1253): 0: 1070: 48.40		PTPRG_HUMAN (295-1445): 0: 670: 21.71
+	Hs
		383771 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRJ_HUMAN (216-1444): 1.65e-118: 405: 14.03
+	Hs
		383836 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRO_HUMAN (1146-1445): 2.99e-94: 333: 28.85
+	Hs
		383545 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRC_HUMAN (879-1156): 7.53e-63: 238: 26.92
+	Hs
		146920 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRT_HUMAN (17-1145): 2.1e-58: 224: 11.95
+	Hs
		383613 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRZ_HUMAN (891-1159): 2.93e-45: 182: 25.71
+	Hs
		383611 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRB_HUMAN (2-813): 4.3e-10: 66.9: 10.42
+	Hs
		337831 EGFR_HUMAN (16-1253): 0: 1070: 48.40		PTPRF_HUMAN (7-941): 1.88e-67: 254: 11.64
+	Hs
		146927 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		PTPRT_HUMAN (17-1145): 2.1e-58: 224: 11.95
+	Hs
		337802 EGFR_HUMAN (16-1253): 0: 1070: 48.40		PTPRC_HUMAN (879-1156): 7.53e-63: 238: 26.92
+	Hs
		146919 EGFR_HUMAN (16-1253): 0: 1070: 48.40		PTPRT_HUMAN (17-1145): 2.1e-58: 224: 11.95
+	Rn
		1143998 ERBB4_RAT (1-1237): 0: 1101: 45.47		PTPRZ_RAT (891-1159): 1.27e-44: 180: 25.00
+	Hs
		337941 EGFR_HUMAN (16-1253): 0: 1070: 48.40		PTPRD_HUMAN (187-963): 3.95e-39: 162: 10.28
+	Hs
		1071017 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		PTPRH_HUMAN (481-885): 1.8e-12: 74.6: 10.58
+	Hs
		337940 EGFR_HUMAN (16-1253): 0: 1070: 48.40		PTPRB_HUMAN (2-813): 4.3e-10: 66.9: 10.42