HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: UTP18 (Q9Y5J1)
U3 small nucleolar RNA-associated protein 18 homolog (WD repeat-containing protein 50)
Gene: UTP18

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	25640309
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1255 Hs			1 556
+	Hs
		383677 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LIS1_HUMAN (284-555): 7.13e-71: 234: 11.34
+	Hs
		383918 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FBXW7_HUMAN (279-555): 2.28e-64: 224: 11.83
+	Hs
		383985 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GBB4_HUMAN (418-554): 2.18e-15: 79.6: 8.03
+	Hs
		383728 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GBB2_HUMAN (398-552): 2.71e-15: 79.2: 7.10
+	Hs
		338250 EGFR_HUMAN (16-1253): 0: 1070: 48.40		GBB2_HUMAN (398-552): 2.71e-15: 79.2: 7.10
+	Hs
		983701 FAK1_HUMAN (706-984): 1.9e-53: 206: 39.07		UTP18_HUMAN (1-556): 7.25e-118: 361: 100.00
+	Hs
		665199 EPHA2_HUMAN (671-1023): 4.87e-117: 390: 33.06		GBB2_HUMAN (398-552): 2.71e-15: 79.2: 7.10
+	Hs
		616847 JAK1_HUMAN (674-1035): 3.11e-43: 174: 21.47		FBXW7_HUMAN (279-555): 2.28e-64: 224: 11.83