HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: AT2A2 (P16615)
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)
Gene: ATP2A2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	25921289, 35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 796 Hs			1 1042
+	Hs
		561588 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		AT2A2_HUMAN (1-1042): 0: 1060: 100.00
+	Hs
		1031158 PTK7_HUMAN (201-781): 9.92e-148: 462: 27.50		AT2A3_HUMAN (1-997): 0: 956: 76.85
+	Hs
		384081 NTRK1_HUMAN (1-796): 0: 621: 100.00		AT1A1_HUMAN (3-997): 0: 797: 26.72
+	Hs
		384189 NTRK1_HUMAN (1-796): 0: 621: 100.00		AT1A3_HUMAN (4-997): 0: 794: 26.55
+	Hs
		507861 FGFR1_HUMAN (195-794): 0: 545: 26.34		AT2B4_HUMAN (3-1028): 0: 762: 25.75
+	Hs
		384651 NTRK1_HUMAN (1-796): 0: 621: 100.00		AT2C1_HUMAN (9-1008): 2.95e-150: 472: 33.93
+	Rn
		416146 INSR_RAT (493-777): 7.31e-66: 241: 41.95		AT1A1_RAT (3-997): 0: 798: 26.82