Protein: CO1A1
Collagen alpha-1(I) chain (Alpha-1 type I collagen)

Gene: CO1A1, COL1A1
Organism: Homo sapiens
Interactions: 168
UniProt ID: P02452

Gene Ontology (top 5):
GO:0001501 - skeletal system development
GO:0001568 - blood vessel development
GO:0001649 - osteoblast differentiation
GO:0001957 - intramembranous ossification
GO:0001958 - endochondral ossification

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

384088

CO1A2
Collagen alpha-2(I) chain

3

17

Small-scale

0.839

High

384086

TSP1
Thrombospondin-1

2

8

Small-scale

0.778

High

191277

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

4

11

Small-scale

0.697

High

384138

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

3

20

Small-scale

0.662

High

384080

VWF
von Willebrand factor

1

14

Small-scale

0.647

High

384125

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

1

19

Small-scale

0.647

High

384137

CO7A1
Collagen alpha-1(VII) chain

1

19

Small-scale

0.647

High

384077

FINC
Fibronectin

3

20

Small-scale

0.646

High

384092

SPRC
SPARC

3

5

Small-scale

0.646

High

384174

YAF2
YY1-associated factor 2

2

1

High-throughput

0.628

High

384175

GT252
Procollagen galactosyltransferase 2

2

20

High-throughput

0.628

High

384116

CO8A2
Collagen alpha-2(VIII) chain

1

20

Small-scale

0.618

High

288884

ERAL1
GTPase Era, mitochondrial

3

2

High-throughput

0.609

High

384170

CMKMT
Calmodulin-lysine N-methyltransferase

3

1

High-throughput

0.609

High

384169

LAIR2
Leukocyte-associated immunoglobulin-like receptor 2

2

16

High-throughput

0.601

High

384107

CO5A1

1

17

Small-scale

0.590

High

384166

TMTC4
Protein O-mannosyl-transferase TMTC4

2

0

High-throughput

0.585

High

384112

TGM2
Protein-glutamine gamma-glutamyltransferase 2

2

4

Small-scale

0.585

High

384106

IBP3
Insulin-like growth factor-binding protein 3

1

5

Small-scale

0.581

High

384075

CO1A1
Collagen alpha-1(I) chain

1

18

Small-scale

0.575

High

384076

CO2A1
Collagen alpha-1(II) chain

1

18

Small-scale

0.575

High

384198

C1QT1
Complement C1q tumor necrosis factor-related protein 1

1

20

High-throughput

0.575

High

221497

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

2

2

High-throughput

0.574

High

384153

KEAP1
Kelch-like ECH-associated protein 1

2

17

High-throughput

0.553

High

376363

PDGFB
Platelet-derived growth factor subunit B

1

11

Small-scale

0.536

High

291979

CRTAP
Cartilage-associated protein

1

3

Small-scale

0.536

High

384083

PDIA1
Protein disulfide-isomerase

1

8

Small-scale

0.536

High

384098

PDIA4
Protein disulfide-isomerase A4

1

8

Small-scale

0.536

High

384099

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

11

Small-scale

0.536

High

384115

PAX3
Paired box protein Pax-3

1

3

High-throughput

0.536

High

384120

ERP29
Endoplasmic reticulum resident protein 29

1

9

Small-scale

0.536

High

384121

PDIA3
Protein disulfide-isomerase A3

1

8

Small-scale

0.536

High

384129

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.536

High

384131

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.536

High

384135

ANK2
Ankyrin-2

1

2

High-throughput

0.536

High

384159

RCN1
Reticulocalbin-1

1

1

Small-scale

0.536

High

384178

GT251
Procollagen galactosyltransferase 1

1

20

Small-scale

0.536

High

384195

ERP44
Endoplasmic reticulum resident protein 44

1

9

Small-scale

0.536

High

384209

DJB11
DnaJ homolog subfamily B member 11

1

1

Small-scale

0.536

High

384210

KLF15
Krueppel-like factor 15

1

2

High-throughput

0.536

High

384216

CHMP3
Charged multivesicular body protein 3

1

4

High-throughput

0.536

High

384218

HYOU1
Hypoxia up-regulated protein 1

1

3

Small-scale

0.536

High

384087

SP1
Transcription factor Sp1

1

2

Small-scale

0.534

High

384150

SMAD4
Mothers against decapentaplegic homolog 4

1

16

Small-scale

0.534

High

384095

THIO
Thioredoxin

1

5

Small-scale

0.527

High

180134

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

4

Small-scale

0.515

High

384146

SIAT6
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase

1

0

High-throughput

0.513

High

384191

TADA1
Transcriptional adapter 1

1

0

High-throughput

0.513

High

384193

ERO1A
ERO1-like protein alpha

1

0

Small-scale

0.513

High

333735

FKBP9
Peptidyl-prolyl cis-trans isomerase FKBP9

2

5

Small-scale

0.504

High

132971

MATN2
Matrilin-2

1

5

Small-scale

0.501

High

215693

COCH
Cochlin

1

13

Small-scale

0.501

High

384079

PDGFA
Platelet-derived growth factor subunit A

1

11

Small-scale

0.501

High

384090

MMP2
72 kDa type IV collagenase

1

20

Small-scale

0.501

High

384101

NID1
Nidogen-1

1

4

Small-scale

0.501

High

384108

MAG
Myelin-associated glycoprotein

1

5

Small-scale

0.501

High

384111

PGS1
Biglycan

1

3

Small-scale

0.501

High

384128

PRELP
Prolargin

1

3

Small-scale

0.501

High

384144

DDR1
Epithelial discoidin domain-containing receptor 1

1

7

Small-scale

0.501

High

384152

NID2
Nidogen-2

1

4

Small-scale

0.501

High

384161

DDR2
Discoidin domain-containing receptor 2

1

7

Small-scale

0.501

High

384096

BIP
Endoplasmic reticulum chaperone BiP

1

3

Small-scale

0.500

High

384102

ENPL
Endoplasmin

1

4

Small-scale

0.500

High

384113

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

2

Small-scale

0.500

High

384126

SERPH
Serpin H1

1

2

Small-scale

0.500

High

384190

FKB10
Peptidyl-prolyl cis-trans isomerase FKBP10

1

5

Small-scale

0.500

High

251184

RNBP6
Ran-binding protein 6

1

1

High-throughput

0.489

High

384127

R144A
E3 ubiquitin-protein ligase RNF144A

1

1

High-throughput

0.489

High

384134

FANCC
Fanconi anemia group C protein

1

1

High-throughput

0.489

High

384142

CDK18
Cyclin-dependent kinase 18

1

1

High-throughput

0.489

High

384162

TMM44
Transmembrane protein 44

1

1

High-throughput

0.489

High

384177

CBLL2
E3 ubiquitin-protein ligase CBLL2

1

2

High-throughput

0.489

High

384214

AKT3
RAC-gamma serine/threonine-protein kinase

1

2

High-throughput

0.489

High

384124

BRCA1
Breast cancer type 1 susceptibility protein

1

4

High-throughput

0.481

High

384094

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

384130

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

217687

TGON2
Trans-Golgi network integral membrane protein 2

1

7

High-throughput

0.479

High

362551

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

384097

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

384103

TIMP2
Metalloproteinase inhibitor 2

1

7

High-throughput

0.479

High

384122

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

1

High-throughput

0.479

High

384132

SMAD3
Mothers against decapentaplegic homolog 3

1

16

Small-scale

0.479

High

384139

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

384147

FOXO1
Forkhead box protein O1

1

1

High-throughput

0.479

High

384151

CUL3
Cullin-3

1

12

High-throughput

0.479

High

384160

SMAD2
Mothers against decapentaplegic homolog 2

1

16

Small-scale

0.479

High

384199

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

4

High-throughput

0.479

High

384156

KI3S1
Killer cell immunoglobulin-like receptor 3DS1

1

16

High-throughput

0.470

High

384085

CAN1
Calpain-1 catalytic subunit

1

0

Small-scale

0.460

High

384110

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

0

Small-scale

0.460

High

384136

CAP1
Adenylyl cyclase-associated protein 1

1

0

High-throughput

0.458

High

384182

MO2R1
Cell surface glycoprotein CD200 receptor 1

1

0

High-throughput

0.458

High

384133

PKD1
Polycystin-1

1

1

Small-scale

0.457

High

384168

LAIR1
Leukocyte-associated immunoglobulin-like receptor 1

1

16

Small-scale

0.457

High

384081

AP2A
Transcription factor AP-2-alpha

1

4

High-throughput

0.457

High

384119

LYOX
Protein-lysine 6-oxidase

1

2

Small-scale

0.457

High

384187

HTRA1
Serine protease HTRA1

1

1

Small-scale

0.457

High

137019

PLOD2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

1

20

Small-scale

0.445

High

229610

CALU
Calumenin

1

1

Small-scale

0.445

High

251836

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

20

Small-scale

0.445

High

384078

ANXA1
Annexin A1

1

4

Small-scale

0.445

High

384082

ITB1
Integrin beta-1

1

3

Small-scale

0.445

High

384084

ANXA2
Annexin A2

1

4

Small-scale

0.445

High

384089

HS90B
Heat shock protein HSP 90-beta

1

4

Small-scale

0.445

High

384100

GLU2B
Glucosidase 2 subunit beta

1

1

Small-scale

0.445

High

384105

ITA2
Integrin alpha-2

1

8

Small-scale

0.445

High

384117

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

1

Small-scale

0.445

High

384123

PEDF
Pigment epithelium-derived factor

1

5

High-throughput

0.445

High

384141

PRDX1
Peroxiredoxin-1

1

1

Small-scale

0.445

High

384143

CKAP4
Cytoskeleton-associated protein 4

1

1

Small-scale

0.445

High

384149

PRDX4
Peroxiredoxin-4

1

1

Small-scale

0.445

High

384158

PDIA6
Protein disulfide-isomerase A6

1

8

Small-scale

0.445

High

384163

P3H1
Prolyl 3-hydroxylase 1

1

3

Small-scale

0.445

High

384164

KLH22
Kelch-like protein 22

1

20

High-throughput

0.445

High

384172

P3H3
Prolyl 3-hydroxylase 3

1

3

Small-scale

0.445

High

384179

TXND5
Thioredoxin domain-containing protein 5

1

8

Small-scale

0.445

High

384180

MCPH1
Microcephalin

1

1

Small-scale

0.439

High

384194

BARD1
BRCA1-associated RING domain protein 1

1

3

High-throughput

0.439

High

384176

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.437

High

384196

NTPCR
Cancer-related nucleoside-triphosphatase

1

1

High-throughput

0.437

High

384200

TRI31
E3 ubiquitin-protein ligase TRIM31

1

2

High-throughput

0.437

High

384204

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.437

High

384205

ANLN
Anillin

1

2

High-throughput

0.437

High

384217

TRAF6
TNF receptor-associated factor 6

1

1

Small-scale

0.437

High

384114

RS3
Small ribosomal subunit protein uS3

1

0

Small-scale

0.426

High

384118

CALR
Calreticulin

1

0

Small-scale

0.426

High

384148

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

Small-scale

0.426

High

384154

GANAB
Neutral alpha-glucosidase AB

1

0

Small-scale

0.426

High

384155

MVP
Major vault protein

1

0

Small-scale

0.426

High

384207

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

0

Small-scale

0.426

High

384212

PARP4
Protein mono-ADP-ribosyltransferase PARP4

1

0

Small-scale

0.426

High

384093

ARMS2
Age-related maculopathy susceptibility protein 2

1

1

Small-scale

0.417

High

384104

ZNF16
Zinc finger protein 16

1

1

Small-scale

0.417

High

384188

AP2C
Transcription factor AP-2 gamma

1

4

High-throughput

0.417

High

384206

DISC1
Disrupted in schizophrenia 1 protein

1

3

High-throughput

0.417

High

384091

RSSA
Small ribosomal subunit protein uS2

1

2

Small-scale

0.407

High

384215

CNPY2
Protein canopy homolog 2

1

1

Small-scale

0.407

High

384165

UBX11
UBX domain-containing protein 11

3

0

High-throughput

0.347

High

384140

TLE3
Transducin-like enhancer protein 3

2

0

High-throughput

0.328

High

384145

RGF1B
Ras-GEF domain-containing family member 1B

2

0

High-throughput

0.328

High

384167

LIN9
Protein lin-9 homolog

2

0

High-throughput

0.328

High

384183

GIPC2
PDZ domain-containing protein GIPC2

2

0

High-throughput

0.318

High

384213

DYN3
Dynamin-3

2

0

High-throughput

0.318

High

384192

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.298

High

384203

AT132
Polyamine-transporting ATPase 13A2

1

0

Small-scale

0.282

High

60617

TESP1
Protein TESPA1

1

0

High-throughput

0.279

Low

136467

GOLI4
Golgi integral membrane protein 4

1

0

Small-scale

0.279

Low

254019

CTND1
Catenin delta-1

1

0

High-throughput

0.279

Low

384109

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.279

Low

384171

PEG10
Retrotransposon-derived protein PEG10

1

0

High-throughput

0.279

Low

384173

BRSK2
Serine/threonine-protein kinase BRSK2

1

0

High-throughput

0.279

Low

384181

S2540
Mitochondrial glutathione transporter SLC25A40

1

0

High-throughput

0.279

Low

384184

TRI41
E3 ubiquitin-protein ligase TRIM41

1

0

High-throughput

0.279

Low

384186

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.279

Low

384189

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.279

Low

384197

ABHEA
Protein ABHD14A

1

0

High-throughput

0.279

Low

384201

EMRE
Essential MCU regulator, mitochondrial

1

0

High-throughput

0.279

Low

384211

FOXD3
Forkhead box protein D3

1

0

High-throughput

0.279

Low

384219

YIPF1
Protein YIPF1

1

0

High-throughput

0.279

Low

220333

LAT
Linker for activation of T-cells family member 1

1

0

High-throughput

0.269

Low

384208

TR10D
Tumor necrosis factor receptor superfamily member 10D

1

0

High-throughput

0.269

Low

293018

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

324386

HEXI1
Protein HEXIM1

1

0

High-throughput

0.249

Low

384157

MF13A
Transmembrane protein 180

1

0

High-throughput

0.249

Low

384185

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

0

High-throughput

0.249

Low

384202

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.249

Low

344055

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025