HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: PDIA3 (P30101)
Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60)
Gene: PDIA3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25921289
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0009986 - cell surface GO:0055038 - recycling endosome membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 796 Hs			1 505
+	Hs
		607891 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		PDIA3_HUMAN (1-505): 6.41e-165: 478: 100.00
+	Hs
		384104 NTRK1_HUMAN (1-796): 0: 621: 100.00		PDIA1_HUMAN (3-482): 1.23e-118: 359: 33.68
+	Hs
		423118 FGFR1_HUMAN (195-794): 0: 545: 26.34		PDIA1_HUMAN (3-482): 1.23e-118: 359: 33.68
+	Hs
		385136 NTRK1_HUMAN (1-796): 0: 621: 100.00		DJC10_HUMAN (27-244): 3.4e-31: 129: 17.39
+	Hs
		385355 NTRK1_HUMAN (1-796): 0: 621: 100.00		TMX3_HUMAN (375-482): 4.46e-27: 115: 37.27
+	Hs
		385431 NTRK1_HUMAN (1-796): 0: 621: 100.00		ERP44_HUMAN (368-496): 4.41e-25: 109: 21.64
+	Hs
		384191 NTRK1_HUMAN (1-796): 0: 621: 100.00		PDIA4_HUMAN (376-505): 1.13e-23: 106: 32.84
+	Hs
		384875 NTRK1_HUMAN (1-796): 0: 621: 100.00		PDIA6_HUMAN (385-471): 3.13e-10: 64.3: 40.91
+	Hs
		1081525 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		DJC10_HUMAN (27-244): 3.4e-31: 129: 17.39
+	Hs
		507820 FGFR1_HUMAN (195-794): 0: 545: 26.34		PDIA4_HUMAN (376-505): 1.13e-23: 106: 32.84
+	Hs
		1081585 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		ERP44_HUMAN (368-496): 4.41e-25: 109: 21.64
+	Hs
		531844 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		PDIA4_HUMAN (376-505): 1.13e-23: 106: 32.84
+	Hs
		423108 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		PDIA1_HUMAN (3-482): 1.23e-118: 359: 33.68
+	Hs
		531720 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		PDIA4_HUMAN (376-505): 1.13e-23: 106: 32.84
+	Hs
		411271 INSR_HUMAN (493-777): 3e-68: 248: 42.62		PDIA1_HUMAN (3-482): 1.23e-118: 359: 33.68
+	Hs
		1067715 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		PDIA6_HUMAN (385-471): 3.13e-10: 64.3: 40.91
+	Hs
		434126 RET_HUMAN (391-794): 3.5e-114: 374: 30.44		PDIA4_HUMAN (376-505): 1.13e-23: 106: 32.84
+	Hs
		435692 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		DJC10_HUMAN (27-244): 3.4e-31: 129: 17.39
+	Hs
		435520 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		PDIA4_HUMAN (376-505): 1.13e-23: 106: 32.84
+	Hs
		411285 INSR_HUMAN (493-777): 3e-68: 248: 42.62		PDIA4_HUMAN (376-505): 1.13e-23: 106: 32.84